Uric Acid: A Biomarker and Pathogenic Factor of Affective Disorders and Neurodegenerative Diseases.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY Current pharmaceutical design Pub Date : 2024-10-16 DOI:10.2174/0113816128333916241003180018

Teng Chu, Ge Liu, Jing Liu, Yue Wu, Weirong Fang

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Abstract

Uric acid (UA), the end-product of purine metabolism, has a complicated physiological role in the body, showing the combination of regulating inflammatory response, promoting oxidation/anti-oxidation, and modifying autophagy activity in vivo. Meanwhile, various research and theories support that inflammation, oxidative stress, and other risk factors promote the onset and progression of affective disorders and neurodegenerative diseases. Existing studies suggest that UA may be involved in the pathophysiological processes of affective disorders in various ways, and there has been a gradual advance in the understanding of the interplay between UA levels and affective disorders and neurodegenerative diseases. This review summarized the role of UA in the process of inflammation, oxidative stress, and autophagy. On this basis, we discussed the correlation between UA and affective disorders and several neurodegenerative diseases, and simultaneously analyzed the possible mechanism of its influence on affective disorders and neurodegenerative diseases, to provide a theoretical basis for UA as a biomarker or therapeutic target for the diagnosis of these diseases.

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尿酸：情感障碍和神经退行性疾病的生物标志物和致病因素。

尿酸（UA）是嘌呤代谢的最终产物，在体内具有复杂的生理作用，表现出调节炎症反应、促进氧化/抗氧化、改变体内自噬活性等综合作用。同时，各种研究和理论都支持炎症、氧化应激和其他危险因素会促进情感障碍和神经退行性疾病的发生和发展。现有研究表明，UA 可能以各种方式参与情感障碍的病理生理过程，人们对 UA 水平与情感障碍和神经退行性疾病之间相互作用的认识也在逐步加深。本综述总结了 UA 在炎症、氧化应激和自噬过程中的作用。在此基础上，探讨了UA与情感障碍及多种神经退行性疾病的相关性，同时分析了UA对情感障碍和神经退行性疾病影响的可能机制，为UA作为诊断这些疾病的生物标志物或治疗靶点提供理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.