A 3-Year Multicentric Study on Switching from Ustekinumab to Guselkumab in Partial Responders with Psoriasis-IL PSO (Italian Landscape Psoriasis).

IF 3.5 3区医学 Q1 DERMATOLOGY Dermatology and Therapy Pub Date : 2024-11-01 Epub Date: 2024-10-13 DOI:10.1007/s13555-024-01270-5

Mario Valenti, Luciano Ibba, Ruggero Cascio Ingurgio, Piergiorgio Malagoli, Andrea Carugno, Marco Campoli, Carlo G Carrera, Francesca M Gaiani, Davide Strippoli, Federica Mola, Angelo V Marzano, Nicola Zerbinati, Anna Minuti, Antonio Costanzo, Alessandra Narcisi

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Abstract

Introduction: Guselkumab, a human monoclonal antibody targeting the p19 subunit of interleukin-23 (IL-23), has shown efficacy in psoriasis and psoriatic arthritis. However, long-term real-world data on its effectiveness in patients with inadequate response to ustekinumab are limited. This study investigates guselkumab's long-term effectiveness and safety in patients with psoriasis with partial response to ustekinumab.

Methods: We performed a retrospective multicentric study analyzing data of patients with psoriasis from seven Italian hospitals between January 2021 and May 2024. The study included 169 patients who switched from ustekinumab to guselkumab. Primary endpoints were Psoriasis Area and Severity Index (PASI) 75, PASI 90, PASI 100, and absolute PASI ≤ 2. Site-specific Physician Global Assessment (PGA) scores were also collected for difficult-to-treat areas.

Results: The study included 169 patients. After 3 years of treatment, PASI 75, PASI 90 and PASI 100 were achieved by 88.4%, 55.8%, and 32.6% of patients, respectively. Site-specific PGA showed significant improvements, especially in the scalp and genital areas. After 3 years of treatment, no significant impact of higher body mass index (BMI) or cardiometabolic comorbidities on guselkumab effectiveness was detected. No severe adverse events were reported during the study period.

Conclusions: In our study, guselkumab provided significant long-term effectiveness and safety in patients partially responsive to ustekinumab, improving both PASI score and site-specific PGA and confirming its potential use for patients with psoriasis switching from ustekinumab.

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关于银屑病部分应答者从 Ustekinumab 转用 Guselkumab 的 3 年多中心研究--IL PSO（意大利景观银屑病）。

简介Guselkumab是一种靶向白细胞介素-23（IL-23）p19亚基的人类单克隆抗体，已显示出对银屑病和银屑病关节炎的疗效。然而，有关其对乌司替尼反应不佳患者疗效的长期实际数据却很有限。本研究调查了古舍库单抗对乌司替库单抗部分应答的银屑病患者的长期有效性和安全性：我们进行了一项回顾性多中心研究，分析了2021年1月至2024年5月期间意大利七家医院的银屑病患者数据。研究纳入了169名从乌司替尼转为古谢库单抗的患者。主要终点是银屑病面积和严重程度指数（PASI）75、PASI 90、PASI 100 和绝对 PASI ≤ 2。对于难以治疗的部位，还收集了特定部位的医生总体评估（PGA）评分：研究包括 169 名患者。治疗 3 年后，分别有 88.4%、55.8% 和 32.6% 的患者达到了 PASI 75、PASI 90 和 PASI 100。特定部位的 PGA 有明显改善，尤其是头皮和生殖器部位。治疗 3 年后，未发现体重指数（BMI）较高或心脏代谢合并症对古舍库单抗疗效有明显影响。研究期间未报告严重不良事件：在我们的研究中，古舍库单抗为对乌司替尼有部分反应的患者提供了显著的长期有效性和安全性，改善了PASI评分和特定部位的PGA，并证实了其在从乌司替尼转归的银屑病患者中的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.