Epidemiology and Healthcare of Juvenile and Late-Onset Acne: Claims Data Analysis.

IF 3.5 3区医学 Q1 DERMATOLOGY Dermatology and Therapy Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI:10.1007/s13555-024-01284-z

Kristina Hagenström, Katharina Müller, Theresa Klinger, Brigitte Stephan, Matthias Augustin

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Abstract

Introduction: Acne is the most frequent chronic inflammatory skin condition in adolescence but occurs also in later age. Our study aimed to characterise the epidemiology, geographical distribution, comorbidity and healthcare of acne juvenilis (AJ) and acne tarda (AT).

Methods: Statutory health insurance (SHI) data from 2016 to 2020 were analysed. Prevalence rates, including geographical distribution, comorbidities and drug use by specialists group, were measured.

Results: In 2020, the prevalence of acne among adults was 1.50% (AT > 25 years) and among adolescents was 3.88% (AT ≤ 25 years). The highest prevalence (13.02%) was observed at the age of 17 years. Sex differences were higher in AT (73.80% in women) than in AJ (64.55% in women). Compared with non-affected persons, individuals with acne - in particular with AT - showed significantly higher rates of skin-related comorbidities, including folliculitis (rate ratio (RR) 8.89), pyoderma (RR 7.27) and rosacea (RR 5.53), and non-skin-related comorbidities, such as ovarian dysfunction (RR 2.36), rhinitis allergica (RR 1.84) and Crohn's disease (RR 1.79). Preferred systemic therapeutics prescribed were anti-infectives in AT (46.86%) and retinoids in AJ (52.35%). In the majority of cases, dermatologists were involved in the treatment of acne (AT 65.77%; AJ 76.27%). The most commonly prescribed topical agents were adapalene with benzoyl peroxide (AT 87.72%; AJ 85.75%), while systemic isotretinoin (AT 81.20%; AJ 90.06%) was also a frequently used drug. General practitioners were more likely to prescribe anti-infectives, especially topical antibiotics such as chlortetracycline (AT 52.38%; AJ 44.44%) and systemic antibiotics, especially tetracycline (AT 58.33%; AJ 67.50%).

Conclusion: Acne affects a relevant proportion of the German population not only in adolescence, and management of this inflammatory skin disease does not naturally follow medical guidelines or specialist recommendations. These findings emphasise the importance of specialised care and comprehensive therapeutic management that should also consider the exploration of comorbidities.

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青少年和晚发性痤疮的流行病学和医疗保健：索赔数据分析。

简介痤疮是青春期最常见的慢性炎症性皮肤病，但也发生在晚年。我们的研究旨在了解幼年痤疮（AJ）和晚发型痤疮（AT）的流行病学、地理分布、合并症和医疗保健的特点：方法：分析了2016年至2020年的法定医疗保险（SHI）数据。方法：对 2016 年至 2020 年的法定医疗保险（SHI）数据进行了分析，测量了患病率，包括地域分布、合并症和各专家小组的药物使用情况：2020年，痤疮在成年人中的发病率为1.50%（发病年龄大于25岁），在青少年中的发病率为3.88%（发病年龄小于25岁）。17 岁时的发病率最高（13.02%）。AT 中的性别差异（女性 73.80%）高于 AJ 中的性别差异（女性 64.55%）。与非患者相比，痤疮患者，尤其是痤疮丙酸杆菌感染者，患皮肤相关合并症（包括毛囊炎（比率比（RR）8.89）、脓疱疮（RR 7.27）和酒渣鼻（RR 5.53））以及非皮肤相关合并症（如卵巢功能障碍（RR 2.36）、过敏性鼻炎（RR 1.84）和克罗恩病（RR 1.79））的比例明显更高。AT（46.86%）和AJ（52.35%）首选的系统治疗药物分别是抗感染药和维甲酸类药物。在大多数病例中，皮肤科医生参与了痤疮的治疗（AT 65.77%；AJ 76.27%）。最常用的外用药物是阿达帕林和过氧化苯甲酰（AT 87.72%；AJ 85.75%），而全身用药异维A酸（AT 81.20%；AJ 90.06%）也是常用药物。全科医生更倾向于处方抗感染药物，特别是金霉素等局部抗生素（AT 52.38%；AJ 44.44%）和全身抗生素，尤其是四环素（AT 58.33%；AJ 67.50%）：痤疮在德国人口中占有相当大的比例，而且不仅发生在青少年时期，这种炎症性皮肤病的治疗并不完全遵循医疗指南或专家建议。这些发现强调了专业护理和综合治疗的重要性，同时也应考虑合并症的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.