Topical Therapies for Periorbital Dyschromia: A 30-Year Review of the Literature.

IF 2.5 3区医学 Q2 DERMATOLOGY Dermatologic Surgery Pub Date : 2024-10-16 DOI:10.1097/DSS.0000000000004429

Emily Woolhiser, Michelle Sobotka, Colin Burnette, Lauren Gawey, Cory A Dunnick

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Abstract

Background: Periorbital dyschromia (POD) is a prevalent dermatologic problem with multifactorial etiology, making treatment outcomes inconsistent and unclear.

Objective: To evaluate and compose a comprehensive review of topical ingredients proven to be effective in the treatment of POD.

Materials and methods: Scopus, PubMed, and OVID databases were searched in a span of 30 years through December 31, 2023, to identify articles with original findings of topical therapies for the treatment of POD. Findings of interest were objectively and subjectively measured regarding pigmentation, skin texture, aesthetic improvement, elasticity, hydration, and eye-bag volume.

Results: The database searches yielded 339 unique studies. After screening and review, 22 studies were included totaling 13 nonrandomized control trials, 7 randomized clinical trials, 1 retrospective case series, and 1 prospective single-arm study. Studies included all reported statistically significant results with topical therapies inclusive of acids, bark extract, bicyclic monoterpene diols, caffeine, combo ingredient serums, ethyl ximenynate, gentiopicroside, glycosaminoglycans, growth factors, topical PRP, and vitamins.

Conclusion: The findings of this review suggest that topical therapies can be effective in the treatment of POD. Future trials should focus on delineating specific etiology of POD and evaluation of therapies specific to their cause.

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眶周畸形的局部疗法：30年文献回顾。

背景：眶周色素沉着症（POD）是一种普遍存在的皮肤病，其病因是多因素的，因此治疗效果不一致且不明确：材料与方法：对 Scopus、PubMed 和 OVID 数据库进行了检索，检索时间跨度为 30 年，截止日期为 2023 年 12 月 31 日，以确定治疗 POD 的外用疗法的原始研究结果的文章。感兴趣的研究结果是对色素沉着、皮肤质地、美学改善、弹性、水合作用和眼袋体积进行客观和主观测量的结果：结果：在数据库中搜索到 339 项独特的研究。经过筛选和审查，共纳入 22 项研究，包括 13 项非随机对照试验、7 项随机临床试验、1 项回顾性病例系列研究和 1 项前瞻性单臂研究。所有纳入的研究都报告了局部疗法（包括酸类、树皮提取物、双环单萜二醇、咖啡因、复合成分血清、西门酸乙酯、龙胆甙、糖胺聚糖、生长因子、局部 PRP 和维生素）在统计学上的显著效果：本综述的研究结果表明，局部疗法可以有效治疗 POD。未来的试验应侧重于明确 POD 的具体病因，并评估针对其病因的疗法。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.