Tyrosine Kinase Inhibitor Induced Proteinuria - A Review.

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2024-10-15 DOI:10.1055/a-2423-3533
J S Gayathri, S Swathi Krishna, M P Rakesh
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Abstract

Tyrosine Kinase inhibitor (TKI) is a class of drugs that interfere with protein kinases' signal transduction pathways through an array of inhibitory mechanisms. Tyrosine kinases (TK) have an inevitable role in downstream signal transduction and the proliferation of tumour cells. Hence, tyrosine kinase inhibitors (TKIs) are frequently employed as anti-neoplastic agents in the treatment of colon, breast, kidney, and lung cancers. They can be used as single or combination therapy with other targeted therapies. It is understood that TKIs pose a risk of developing proteinuria in some patients as it can primarily result in dysfunction of the split diaphragm, constriction or blockage of capillary lumens mediated by the basement membrane, acute interstitial nephritis, or acute tubular necrosis. This paper reviews the mechanism of action of TKIs, the pathophysiological mechanism of TKI-induced proteinuria, and its management Fig. 1.

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酪氨酸激酶抑制剂诱发的蛋白尿--综述。
酪氨酸激酶抑制剂(TKI)是一类通过一系列抑制机制干扰蛋白激酶信号转导途径的药物。酪氨酸激酶(TK)在下游信号转导和肿瘤细胞增殖中发挥着不可避免的作用。因此,酪氨酸激酶抑制剂(TKIs)经常被用作治疗结肠癌、乳腺癌、肾癌和肺癌的抗肿瘤药物。它们可作为单一疗法或与其他靶向疗法联合使用。据了解,TKIs 会给一些患者带来出现蛋白尿的风险,因为它主要会导致分裂膈功能障碍、基底膜介导的毛细血管管腔收缩或堵塞、急性间质性肾炎或急性肾小管坏死。本文综述了 TKIs 的作用机制、TKI 诱导蛋白尿的病理生理机制及其处理方法 图 1。
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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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