Solving the protein folding problem….

IF 3.5 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology FEBS Letters Pub Date : 2024-10-20 DOI:10.1002/1873-3468.15043
Roy D Sleator
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Abstract

The protein folding problem was, to paraphrase Churchill, 'A riddle wrapped in a mystery inside an enigma'. The riddle, in this context, was the folding code; what interactions at the amino acid level are driving the folding process? The mystery was the kinetic question (Levinthal's paradox); how does the folding process occur so quickly (typically in timescales ranging from μS to mS)? Finally, the enigma represents the computational problem of developing approaches to predict the final folded sate of a protein given only its amino acid sequence. Herein, I trace the path to solving this riddle wrapped in a mystery inside an enigma.

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解决蛋白质折叠问题....
用丘吉尔的话来说,蛋白质折叠问题是 "谜中之谜"。在这种情况下,谜底就是折叠密码;是什么在氨基酸水平上的相互作用推动了折叠过程?谜底是动力学问题(莱文塔尔悖论);折叠过程为何发生得如此之快(时间尺度通常从微秒到毫秒不等)?最后,这个谜团代表了一个计算问题,即如何在仅给出氨基酸序列的情况下,开发出预测蛋白质最终折叠状态的方法。在此,我将追溯解开这个谜中之谜的路径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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