Pregnancy zone protein, a potential research target in multiple diseases

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-10-19 DOI:10.1016/j.gene.2024.149013

You Wu , Zhicong Zhao , Xia Deng , Jue Jia , Guoyue Yuan

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Abstract

Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer’s disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases.

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妊娠区蛋白--多种疾病的潜在研究目标。

妊娠区蛋白（PZP）是一种抗蛋白酶的免疫抑制剂，属于α-巨球蛋白（αM）蛋白家族。α-2-巨球蛋白（Α2M）与 PZP 有 71% 的序列同源性，但 PZP 水平低不会导致孕期 A2M 水平升高。PZP 可与多种因子相互作用，如低密度脂蛋白受体相关蛋白（LRP）、转化生长因子-β（TGF-β）、78 kDa 葡萄糖调节蛋白（GRP78）和糖苷 A（GdA）。PZP 与糖脂代谢紊乱、支气管扩张、阿尔茨海默病（AD）、类风湿性关节炎（RA）、心肌梗塞（MI）和炎症性肠病（IBD）的发病有关。PZP 还与乳腺癌（BC）、同种异形细胞癌（HCC）、肺腺癌（LAC）和结直肠癌（CRC）等肿瘤的发生发展有关。因此，本综述分析了 PZP 在各种疾病的病理生理学中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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