The Efficacy of Post-Exposure Prophylaxis in Infants Born to HBsAg-Positive Mothers: A Single Center Experience in Saudi Arabia.

IF 1.4 Q3 PEDIATRICS Global Pediatric Health Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI:10.1177/2333794X241290780
Mansour Al Qurashi, Hanan Al-Najjar, Syed Sameer Aga, Hadeel Mohammad, Ahmed Mustafa, Mohammed Al Hindi, Abrar Ahmed, Mohammad Al Harbi, Mohammad Hasosah, Ashraf Alsahaf, Mona Aldabbagh, Sara Abed
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Abstract

Objectives. Post exposure prophylaxis (PEP) with the hepatitis B vaccine (HBVac) in combination with HBV immunoglobulins (HBIG) significantly minimizes the odds of vertical transmission of HBV to newborn infants. In this retrospective study, we aimed to evaluate the compliance and efficacy of PEP in a tertiary care center in Saudi Arabia. Methods. Infants were tested with HBV serological markers at 7 months of age to assess their PEP protection rate. Results. Out of 13,125 mothers who delivered in KAMC, 105 (0.8%) mothers were found to have HBsAg positive, with a prevalence of 8 per 1000 live births. All infants (n = 100) completed their PEP as per protocol before discharge from the hospital (2 days after delivery). Among infants (n = 59; 56.2%) who were tested at 7 months of age, all (100%) were found to be negative for HBV. Conclusion. PEP achieved 100% efficacy among infants who complied with the study protocol at 7 months of follow-up. The prevalence of hepatitis B among pregnant women was 8 per 1000 live births.

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HBsAg 阳性母亲所生婴儿暴露后预防的疗效:沙特阿拉伯单中心经验。
目标。使用乙肝疫苗(HBVac)联合 HBV 免疫球蛋白(HBIG)进行暴露后预防(PEP)可大大降低 HBV 垂直传播给新生儿的几率。在这项回顾性研究中,我们旨在评估沙特阿拉伯一家三级医疗中心中 PEP 的依从性和有效性。研究方法对 7 个月大的婴儿进行 HBV 血清学标记检测,以评估他们的 PEP 保护率。结果。在 KAMC 分娩的 13125 名母亲中,105 名(0.8%)母亲的 HBsAg 阳性,发病率为每 1000 名活产婴儿中 8 例。所有婴儿(n = 100)都在出院前(产后 2 天)按照规定完成了预防性治疗。在 7 个月大时接受检测的婴儿(n = 59;56.2%)中,所有婴儿(100%)的 HBV 检测结果均为阴性。结论。在 7 个月的随访中,PEP 在遵守研究方案的婴儿中达到了 100% 的有效率。乙型肝炎在孕妇中的发病率为每 1000 名活产婴儿中有 8 例。
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来源期刊
Global Pediatric Health
Global Pediatric Health Nursing-Pediatrics
CiteScore
2.20
自引率
0.00%
发文量
105
审稿时长
12 weeks
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