Effects of various exercise types on inflammatory response in individuals with overweight and obesity: a systematic review and network meta-analysis of randomized controlled trials.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM International Journal of Obesity Pub Date : 2024-10-17 DOI:10.1038/s41366-024-01649-6
Chaofan Chen, Dong Zhang, Mingyi Ye, Yanwei You, Yiling Song, Xiaoke Chen
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Abstract

Objective: To explore effective exercise types for reducing chronic inflammation in individuals with overweight and obesity (IOO) while accounting for confounders.

Methods: A systematic search for RCTs in English between January 2000 and August 2023 was conducted to evaluating exercise effects on inflammatory biomarkers in IOO. A network meta-analysis conducted.

Results: A total of 123 RCTs were analyzed. Different exercise type yielded distinct effects on various inflammatory biomarkers. Specifically, aerobic exercise combined with resistance training (COM) and aerobic exercise (AE) were the most effective for improving leptin levels. AE exhibited the greatest effectiveness in reducing CRP and increasing adiponectin. High-intensity interval training (HIIT) was identified as the most effective exercise modality for ameliorating IL-6, TNF-α, and IL-10. Resistance training (RT) had the least effect compared to other exercise types. Meta regression and subgroup analyses revealed that high-intensity AE demonstrated a greater effect size compared to moderate-intensity AE. The impact of AE on IL-10 was positively associated with both the training period and the age of participants. Positive correlations were observed between reductions in body fat and the effect sizes of CRP, TNF-α, and IL-10. Gender influenced AE effects on IL-6 and TNF-α, with females responding better.

Conclusion: This study highlights the potential of exercise in alleviating the inflammatory status in IOO, with different exercise types showing various effects on specific inflammatory biomarkers. The intensity and duration of exercise had a dose-response relationship with intervention effectiveness. Changes in body composition correlated with the effectiveness of the intervention. COM, AE, and HIIT are recommended exercise approaches.

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各种运动类型对超重和肥胖症患者炎症反应的影响:随机对照试验的系统回顾和网络荟萃分析。
目的在考虑混杂因素的情况下,探索减少超重和肥胖症(IOO)患者慢性炎症的有效运动类型:方法:系统检索2000年1月至2023年8月期间的英文RCT,评估运动对超重和肥胖症患者炎症生物标志物的影响。结果:共收集到 123 项研究数据:结果:共分析了 123 项研究。不同的运动类型对各种炎症生物标志物产生了不同的影响。具体而言,有氧运动结合阻力训练(COM)和有氧运动(AE)对改善瘦素水平最有效。有氧运动在降低 CRP 和增加脂肪连通素方面的效果最好。高强度间歇训练(HIIT)被认为是改善 IL-6、TNF-α 和 IL-10 最有效的运动方式。与其他运动方式相比,阻力训练(RT)的效果最小。元回归和亚组分析显示,与中等强度的AE相比,高强度AE的效果更大。AE对IL-10的影响与训练时间和参与者的年龄呈正相关。体脂减少与CRP、TNF-α和IL-10的效应大小呈正相关。性别影响了 AE 对 IL-6 和 TNF-α 的影响,女性的反应更好:本研究强调了运动在缓解 IOO 炎症状态方面的潜力,不同类型的运动对特定炎症生物标志物有不同的影响。运动强度和持续时间与干预效果呈剂量反应关系。身体成分的变化与干预效果相关。建议采用COM、AE和HIIT等运动方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Obesity
International Journal of Obesity 医学-内分泌学与代谢
CiteScore
10.00
自引率
2.00%
发文量
221
审稿时长
3 months
期刊介绍: The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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