Polysaccharides and Peptides With Wound Healing Activity From Bacteria and Fungi.

IF 3.5 4区 生物学 Q2 MICROBIOLOGY Journal of Basic Microbiology Pub Date : 2024-10-16 DOI:10.1002/jobm.202400510
Nazli Pinar Arslan, Tugba Orak, Aysenur Ozdemir, Ramazan Altun, Nevzat Esim, Elvan Eroglu, Sinem Ilayda Karaagac, Cigdem Aktas, Mesut Taskin
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Abstract

Bacteria and fungi are natural sources of metabolites exhibiting diverse bioactive properties such as wound healing, antioxidative, antibacterial, antifungal, anti-inflammatory, antidiabetic, and anticancer activities. Two important groups of bacteria or fungi-derived metabolites with wound-healing potential are polysaccharides and peptides. In addition to bacteria-derived cellulose and hyaluronic acid and fungi-derived chitin and chitosan, these organisms also produce different polysaccharides (e.g., exopolysaccharides) with wound-healing potential. The most commonly used bacterial peptides in wound healing studies are bacteriocins and lipopeptides. Bacteria or fungi-derived polysaccharides and peptides exhibit both the in vitro and the in vivo wound healing potency. In the in vivo models, including animals and humans, these metabolites positively affect wound healing by inhibiting pathogens, exhibiting antioxidant activity, modulating inflammatory response, moisturizing the wound environment, promoting the proliferation and migration of fibroblasts and keratinocytes, increasing collagen synthesis, re-epithelialization, and angiogenesis. Therefore, peptides and polysaccharides derived from bacteria and fungi have medicinal importance. This study aims to overview current literature knowledge (especially within the past 5 years) on the in vitro and in vivo wound repair potentials of polysaccharides and peptides obtained from bacteria (Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, and Proteobacteria) and fungi (yeasts, filamentous microfungi, and mushrooms).

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细菌和真菌中具有伤口愈合活性的多糖和肽。
细菌和真菌是多种代谢物的天然来源,它们具有多种生物活性,如伤口愈合、抗氧化、抗菌、抗真菌、消炎、抗糖尿病和抗癌活性。多糖和肽是细菌或真菌产生的具有伤口愈合潜力的两类重要代谢物。除了细菌产生的纤维素和透明质酸以及真菌产生的几丁质和壳聚糖外,这些生物还产生不同的具有伤口愈合潜能的多糖(如外多糖)。伤口愈合研究中最常用的细菌肽是细菌素和脂肽。细菌或真菌衍生的多糖和肽具有体外和体内伤口愈合能力。在包括动物和人体在内的体内模型中,这些代谢物通过抑制病原体、抗氧化、调节炎症反应、保湿伤口环境、促进成纤维细胞和角质细胞的增殖和迁移、增加胶原蛋白合成、再上皮化和血管生成,对伤口愈合产生积极影响。因此,从细菌和真菌中提取的肽和多糖具有重要的药用价值。本研究旨在概述目前有关从细菌(放线菌、类杆菌、蓝藻菌、真菌和蛋白菌)和真菌(酵母菌、丝状微真菌和蘑菇)中提取的多糖和肽的体外和体内伤口修复潜力的文献知识(尤其是过去 5 年内的知识)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Basic Microbiology
Journal of Basic Microbiology 生物-微生物学
CiteScore
6.10
自引率
0.00%
发文量
134
审稿时长
1.8 months
期刊介绍: The Journal of Basic Microbiology (JBM) publishes primary research papers on both procaryotic and eucaryotic microorganisms, including bacteria, archaea, fungi, algae, protozoans, phages, viruses, viroids and prions. Papers published deal with: microbial interactions (pathogenic, mutualistic, environmental), ecology, physiology, genetics and cell biology/development, new methodologies, i.e., new imaging technologies (e.g. video-fluorescence microscopy, modern TEM applications) novel molecular biology methods (e.g. PCR-based gene targeting or cassettes for cloning of GFP constructs).
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