Lu Rao , Fei Chen , Ming-Hui Gao , Jun-Jie Tan , Shi-Jin Qu , Chang-Heng Tan
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引用次数: 0
Abstract
Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-epi-rhynchophylloside A (1), 7-epi-rhynchophylloside A (2), and 7-epi-anthocephalusine A (3), were isolated from the hook-bearing branches of Uncaria rhynchophylla. The structures and absolute configurations of 1–3 were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids 1 and 3 showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.
从钩吻科植物钩吻的生枝中分离出12种单萜烯吲哚糖生物碱，包括3种新的单萜烯吲哚糖生物碱，即19-epi-rhynchophylloside A (1)、7-epi-rhynchophylloside A (2)和7-epi-anthocephalusine A (3)。通过分析 MS、NMR、ECD 和单晶 X 射线衍射或 TDDFT-ECD 计算，阐明了 1-3 的结构和绝对构型。糖生物碱 1 和 3 对 LPS 诱导的 B 淋巴细胞增殖具有显著的免疫抑制活性，并具有广泛的选择性。
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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