Midterm single center results with the use of custom-made endografts with inner branches, a call for attention.

Abstract

Objective: To evaluate the patency of bridging covered stents (BCS) bridged to inner branches in custom-made thoracoabdominal endografts.

Methods: Single-center retrospective study identifying all patients undergoing fenestrated or branched endovascular aortic repair (f/b EVAR) in whom the reno-visceral target vessels (TV) were bridged with a BCS to an inner branch of a custom made (CMD) endograft.. Technical success and perioperative complications were noted. Follow-up BCS patency were evaluated and in patients with follow-up, two groups based on BCS were created, a group with BCS occlusion and a group with BCS patent. Uni und multivariable analysis were performed to analyze factors related to visceral and renal bridging stent occlusion.

Results: From 2019-2022, 69 patients undergoing complex aortic repair had at least one TV bridged to an inner branch built into a CMD endograft. 86% of the grafts had only inner branches, whereas 14% had a mix of fenestrations for the visceral TV and inner branches for the renal arteries. Twenty-five percent of patients presented as urgency and received an endograft originally designed for another patient and available on our shelf at the time. 245 TVs were connected to inner branches: celiac trunk (CT): 54, superior mesenteric artery (SMA): 59, renal artery (RA): 132. Technical success was 99%. There was a 23% complication and 9% perioperative mortality rate. At follow-up, we identified 6% of visceral and 14% of renal BCS occlusions. The primary patency for RA BCS was 83% at 12 months and 58% at 24 months. For the CT-SMA BCS, Kaplan-Maier (KM) showed a patency of 99% and 96% at 12 and 24 months. In the univariate analysis a misaligned TV ostium (p 0.001), the postoperative BCS diameter on postoperative CTA (p 0.02) and the preoperative infrarenal aortic angle >60º (0.007) were correlated with RA BCS occlusion. In the multivariate analysis only the misaligned TV ostium (p 0.002) and infrarenal angle > 60° (p 0.01) were significantly correlated.

Conclusions: In our series of complex aortic repair, the incorporation of inner branches to bridge TVs is associated with a high renal BCS occlusion rate. Improper alignment of the branches with the TV ostium and acute aortic angles might play a significant role. Further research on this technology is needed.