Proteins-Based Nanoparticles for Benznidazole Enteric Delivery

IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Macromolecular bioscience Pub Date : 2024-10-18 DOI:10.1002/mabi.202400338
Victor A. Pilicita, Ana S. Sonzogni, Mariana Allasia, Florencia Borra, Roque J. Minari, Verónica D.G. Gonzalez
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Abstract

Chagas disease, caused by Trypanosoma cruzi (T. cruzi), affects millions worldwide, particularly in Latin America. Despite its prevalence, treatment options remain limited. Current drugs, such as benznidazole, cause adverse effects possibly due to ineffective administration. In this context, nanoparticles offer a promising solution to target and control drug delivery by leading the effector site and minimizing side effects. This article focuses on zein-casein-based nanoparticles (Bioparticles, BP) coated with Eudragit L100-55 (BP:EU) for enteric delivery of benznidazole. BP:EU structures are synthesized to minimize premature drug release in the stomach, promoting release in the small intestine. Physical characterization confirmed the successful synthesis of BP:EU and their pH-responsive trigger for drug release. These findings suggest that this material can be a promising approach for Chagas disease treatment, addressing challenges in benznidazole delivery that can lead to improved therapeutic responses.

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基于蛋白质的苯并咪唑肠道给药纳米颗粒
由克鲁斯锥虫(T. cruzi)引起的恰加斯病影响着全球数百万人,尤其是拉丁美洲人。尽管该病很普遍,但治疗方案仍然有限。目前的药物(如苯并咪唑)可能会因用药不当而产生不良反应。在这种情况下,纳米颗粒提供了一种很有前景的解决方案,通过引导作用部位来靶向和控制给药,并最大限度地减少副作用。本文重点研究了涂有 Eudragit L100-55 (BP:EU)的玉米蛋白-酪蛋白基纳米颗粒(Bioparticles,BP),用于苯并咪唑的肠道给药。合成 BP:EU 结构可最大限度地减少药物在胃中的过早释放,促进药物在小肠中的释放。物理表征证实了 BP:EU 的成功合成及其释放药物的 pH 响应触发器。这些研究结果表明,这种材料是治疗南美锥虫病的一种很有前景的方法,它解决了苯并咪唑给药方面的难题,从而提高了治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Macromolecular bioscience
Macromolecular bioscience 生物-材料科学:生物材料
CiteScore
7.90
自引率
2.20%
发文量
211
审稿时长
1.5 months
期刊介绍: Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
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