Nitric oxide-based treatments improve wound healing associated with diabetes mellitus.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI:10.4103/mgr.MEDGASRES-D-24-00020
Zahra Bahadoran, Parvin Mirmiran, Farhad Hosseinpanah, Khosrow Kashfi, Asghar Ghasemi
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Abstract

Non-healing wounds are long-term complications of diabetes mellitus (DM) that increase mortality risk and amputation-related disability and decrease the quality of life. Nitric oxide (NO·)-based treatments (i.e., use of both systemic and topical NO· donors, NO· precursors, and NO· inducers) have received more attention as complementary approaches in treatments of DM wounds. Here, we aimed to highlight the potential benefits of NO·-based treatments on DM wounds through a literature review of experimental and clinical evidence. Various topical NO·-based treatments have been used. In rodents, topical NO·-based therapy facilitates wound healing, manifested as an increased healing rate and a decreased half-closure time. The wound healing effect of NO·-based treatments is attributed to increasing local blood flow, angiogenesis induction, collagen synthesis and deposition, re-epithelization, anti-inflammatory and anti-oxidative properties, and potent broad-spectrum antibacterial effects. The existing literature lacks human clinical evidence on the safety and efficacy of NO·-based treatments for DM wounds. Translating experimental favors of NO·-based treatments of DM wounds into human clinical practice needs conducting clinical trials with well-predefined effect sizes, i.e., wound reduction area, rate of wound healing, and hospital length of stay.

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基于一氧化氮的疗法可改善与糖尿病相关的伤口愈合。
伤口不愈合是糖尿病(DM)的长期并发症,会增加死亡风险和截肢相关残疾,并降低生活质量。以一氧化氮(NO)为基础的治疗方法(即全身和局部使用一氧化氮供体、一氧化氮前体和一氧化氮诱导剂)作为治疗糖尿病伤口的补充方法受到越来越多的关注。在此,我们旨在通过对实验和临床证据的文献综述,强调基于 NO 的治疗方法对 DM 伤口的潜在益处。目前已经使用了多种基于 NO 的局部治疗方法。在啮齿类动物中,氮氧化物外用疗法可促进伤口愈合,表现为愈合率提高和半闭合时间缩短。氮氧化物疗法的伤口愈合效果归因于增加局部血流量、诱导血管生成、胶原蛋白合成和沉积、重新上皮、抗炎和抗氧化特性以及强效广谱抗菌作用。现有文献缺乏以 NO 为基础的 DM 伤口治疗方法的安全性和有效性的人体临床证据。要将基于氮氧化物的 DM 伤口治疗方法的实验优势转化为人类临床实践,需要开展具有明确效应大小(即伤口缩小面积、伤口愈合率和住院时间)的临床试验。
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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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