Coprophenomena Associated With Worse Individual and Family Function for Youth With Tourette Syndrome: A Cross-Sectional Study.

IF 2.3 Q3 CLINICAL NEUROLOGY Neurology. Clinical practice Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI:10.1212/CPJ.0000000000200369
Samantha P Myers, Kathleen D Meeks, Heather Adams, Amy E Vierhile, Erika Augustine, Alyssa Collins, Adam B Lewin, Tanya K Murphy, Jonathan W Mink, Jennifer Vermilion
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引用次数: 0

Abstract

Background and objectives: Tourette syndrome (TS) is defined by multiple motor tics and one or more phonic tics with a symptom duration of >1 year. Coprophenomena are uncommon tics characterized by obscene sounds, words, or gestures. Youth with TS commonly have psychiatric co-occurring conditions such as attention-deficit hyperactivity disorder or obsessive-compulsive disorder and have reported lower scores on measures of individual and family functioning than youth without TS. This study aimed to determine associations among co-occurring condition symptoms, tic severity, and function in youth with TS and coprophenomena compared with those with TS without coprophenomena.

Methods: Data were collected through a multicenter, cross-sectional study. Youth with TS were recruited from 2 referral centers, and data were collected from youth and their parents or caregivers. Tic severity was assessed using the Yale Global Tic Severity Scale, and individual function was measured with the Children's Global Assessment Scale. Family impact was measured using the Family Impact Module in domains of parent health-related quality of life (HRQOL), family functioning, and total family impact. We compared individual and family function in youth with TS with coprophenomena (TS+copro) and without coprophenomena (TS-copro). Wilcoxon rank-sum tests were used to compare scores on individual function and family function measures.

Results: Of 169 participants, 17 (10.1%) reported coprophenomena. Participants with TS and coprophenomena had higher tic severity scores than those without coprophenomena (TS+copro mean = 36.9, TS-copro = 20.8). Youth with coprophenomena had lower scores for global function (TS+copro median = 51, TS-copro = 60), family functioning (TS+copro = 43.8, TS-copro = 59.4), parent HRQOL (TS+copro = 57, TS-copro = 72), and total family QOL (TS+copro = 50.7, TS-copro = 65.3).

Discussion: Youth with TS and coprophenomena had lower individual function, family function, and parent HRQOL than youth without coprophenomena. Coprophenomena presence may indicate that youth have a more severe phenotype of TS, and youth with copropheneomena may benefit from additional caregiver or family supports.

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与妥瑞症青少年个人和家庭功能恶化相关的共生现象:一项横断面研究
背景和目的:图雷特综合征(TS)是指症状持续时间超过 1 年的多种运动性抽搐和一种或多种发音性抽搐。共相现象是以猥亵的声音、言语或手势为特征的不常见抽搐。患有 TS 的青少年通常同时患有注意力缺陷多动障碍或强迫症等精神疾病,并且在个人和家庭功能测量中的得分低于无 TS 的青少年。本研究旨在确定与无并发症的 TS 患者相比,患有 TS 和并发症的青少年的并发症症状、抽搐严重程度和功能之间的关联:通过一项多中心横断面研究收集数据。从两个转诊中心招募了患有 TS 的青少年,并从青少年及其父母或看护人处收集了数据。抽搐严重程度采用耶鲁全球抽搐严重程度量表进行评估,个人功能采用儿童全球评估量表进行测量。家庭影响采用家庭影响模块进行测量,包括父母健康相关生活质量 (HRQOL)、家庭功能和总体家庭影响。我们比较了有共患现象(TS+copro)和无共患现象(TS-copro)的 TS 青少年的个人和家庭功能。我们使用 Wilcoxon 秩和检验来比较个人功能和家庭功能测量的得分:在 169 名参与者中,有 17 人(10.1%)报告了共患现象。与没有共患现象的参与者相比,有TS和共患现象的参与者的抽搐严重程度得分更高(TS+共患现象的平均分=36.9,TS-共患现象的平均分=20.8)。患有共患现象的青少年在整体功能(TS+copro 中位数 = 51,TS-copro = 60)、家庭功能(TS+copro = 43.8,TS-copro = 59.4)、父母 HRQOL(TS+copro = 57,TS-copro = 72)和家庭总 QOL(TS+copro = 50.7,TS-copro = 65.3)方面的得分较低:讨论:与没有共患现象的青少年相比,患有TS并伴有共患现象的青少年的个人功能、家庭功能和父母的HRQOL均较低。共现现象的出现可能表明青少年的TS表型更为严重,共现现象的青少年可能会从额外的照顾者或家庭支持中受益。
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来源期刊
Neurology. Clinical practice
Neurology. Clinical practice CLINICAL NEUROLOGY-
CiteScore
4.00
自引率
0.00%
发文量
77
期刊介绍: Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.
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