Exhaled Breath Condensate Surveillance for Aspergillus in Acute Leukemia-a Pilot Trial.

IF 3.8 4区 医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2024-09-24 eCollection Date: 2024-10-01 DOI:10.1093/ofid/ofae537
Roni Bitterman, Simran Arora, Chun Fai Ng, Laura Walti, Syed Zain Ahmad, Toufik Safi, Vikas Gupta, Shahid Husain
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Abstract

Invasive fungal infections in patients with leukemia carry a high mortality rate, but early diagnosis has the potential to modify this natural history. A novel screening method using Aspergillus droplet-digital polymerase chain reaction in exhaled breath condensate may have a similar performance to serum galactomannan screening. Larger studies, including other molds, are necessary.

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急性白血病患者呼出气体冷凝物曲霉菌监测--一项试点试验。
白血病患者的侵袭性真菌感染死亡率很高,但早期诊断有可能改变这一自然病史。在呼出的冷凝液中使用曲霉菌液滴-数字聚合酶链反应的新型筛查方法可能与血清半乳甘露聚糖筛查具有相似的效果。有必要进行包括其他霉菌在内的更大规模的研究。
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来源期刊
Open Forum Infectious Diseases
Open Forum Infectious Diseases Medicine-Neurology (clinical)
CiteScore
6.70
自引率
4.80%
发文量
630
审稿时长
9 weeks
期刊介绍: Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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