Efficacy of Combined vs. Monotherapy in Oral Lichen Planus: A Randomized Clinical Trial.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-10-22 DOI:10.1111/odi.15151

Rocio Rodriguez-Galvez, Asta Tvarijonaviciute, Camila Peres-Rubio, Pia Lopez-Jornet

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引用次数: 0

Abstract

Objectives: The aim of this study was to compare the topical therapeutic efficacy of triamcinolone acetonide (TA) (0.2%) plus hyaluronic acid (HA) (0.1%) versus monotherapy in patients with symptomatic oral lichen planus (OLP), as well as to investigate the oxidative stress of saliva under the different treatments.

Materials and methods: Sixty OLP patients were included in a randomized, double-blind, singlecenter study with a treatment duration of 28 days and 3-month follow-up period. Participants were randomized into three groups: Group I (TA + HA), Group II (TA), and Group III (HA). Treatment efficacy was assessed by means of Thongprasom scale, Oral Health Impact Profile-14 (OHIP-14), and visual analog scale (VAS). In addition, biochemical analyses were performed in order to determine the level of antioxidant biomarkers in saliva, including superoxide dismutase (SOD), glutathione (GSH), and total antioxidant capacity (TAC).

Results: All treatments seem to exhibit a significant effect in accordance with Thongprasom scale (p < 0.001), VAS reduction (p < 0.001), and OHIP14 (p < 0.05), which maintains over time. No significant changes in salivary oxidative stress in any of the three groups occurred.

Conclusions: The results exhibited a significant improvement in the treated patients in all three groups. There were no significant changes in salivary stress biomarkers under treatment condition.

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口腔扁平苔藓联合疗法与单一疗法的疗效对比：随机临床试验

研究目的本研究旨在比较曲安奈德（TA）（0.2%）加透明质酸（HA）（0.1%）与单一疗法对有症状的口腔扁平苔藓（OLP）患者的局部疗效，并调查不同疗法下唾液的氧化应激情况：60名OLP患者参加了一项随机、双盲、单中心研究，疗程28天，随访3个月。参与者被随机分为三组：第一组（TA + HA）、第二组（TA）和第三组（HA）。治疗效果通过Thongprasom量表、口腔健康影响档案-14（OHIP-14）和视觉模拟量表（VAS）进行评估。此外，还进行了生化分析，以确定唾液中的抗氧化生物标志物水平，包括超氧化物歧化酶（SOD）、谷胱甘肽（GSH）和总抗氧化能力（TAC）：根据 Thongprasom 量表（P 结论），所有治疗方法似乎都有显著效果：结果显示，三组患者的治疗效果均有明显改善。在治疗条件下，唾液压力生物标志物没有发生明显变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.