Clustering Functional Data With Measurement Errors: A Simulation-Based Approach.

IF 1.8 4区 医学 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY Statistics in Medicine Pub Date : 2024-12-10 Epub Date: 2024-10-15 DOI:10.1002/sim.10238
Tingyu Zhu, Lan Xue, Carmen Tekwe, Keith Diaz, Mark Benden, Roger Zoh
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Abstract

Clustering analysis of functional data, which comprises observations that evolve continuously over time or space, has gained increasing attention across various scientific disciplines. Practical applications often involve functional data that are contaminated with measurement errors arising from imprecise instruments, sampling errors, or other sources. These errors can significantly distort the inherent data structure, resulting in erroneous clustering outcomes. In this article, we propose a simulation-based approach designed to mitigate the impact of measurement errors. Our proposed method estimates the distribution of functional measurement errors through repeated measurements. Subsequently, the clustering algorithm is applied to simulated data generated from the conditional distribution of the unobserved true functional data given the observed contaminated functional data, accounting for the adjustments made to rectify measurement errors. We illustrate through simulations show that the proposed method has improved numerical performance than the naive methods that neglect such errors. Our proposed method was applied to a childhood obesity study, giving more reliable clustering results.

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有测量误差的功能数据聚类:基于模拟的方法
功能数据由随时间或空间不断变化的观测数据组成,对功能数据进行聚类分析在各个科学学科中越来越受到关注。在实际应用中,功能数据往往会受到不精确仪器、抽样误差或其他来源造成的测量误差的污染。这些误差会严重扭曲固有的数据结构,导致错误的聚类结果。在本文中,我们提出了一种基于模拟的方法,旨在减轻测量误差的影响。我们提出的方法通过重复测量来估计功能测量误差的分布。随后,将聚类算法应用于模拟数据,模拟数据由未观察到的真实功能数据的条件分布生成,并考虑到为纠正测量误差而进行的调整。我们通过仿真说明,与忽略此类误差的天真方法相比,所提出的方法在数值性能上有所改进。我们提出的方法被应用于一项儿童肥胖症研究,得出了更可靠的聚类结果。
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来源期刊
Statistics in Medicine
Statistics in Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.40
自引率
10.00%
发文量
334
审稿时长
2-4 weeks
期刊介绍: The journal aims to influence practice in medicine and its associated sciences through the publication of papers on statistical and other quantitative methods. Papers will explain new methods and demonstrate their application, preferably through a substantive, real, motivating example or a comprehensive evaluation based on an illustrative example. Alternatively, papers will report on case-studies where creative use or technical generalizations of established methodology is directed towards a substantive application. Reviews of, and tutorials on, general topics relevant to the application of statistics to medicine will also be published. The main criteria for publication are appropriateness of the statistical methods to a particular medical problem and clarity of exposition. Papers with primarily mathematical content will be excluded. The journal aims to enhance communication between statisticians, clinicians and medical researchers.
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