Choroidal biomarkers in age-related macular degeneration

IF 5.1 2区医学 Q1 OPHTHALMOLOGY Survey of ophthalmology Pub Date : 2024-10-18 DOI:10.1016/j.survophthal.2024.10.004

Elham Sadeghi MD , Nicola Valsecchi MD , Elham Rahmanipour MD , Mahsa Ejlalidiz MD , Nasiq Hasan MD , Kiran Kumar Vupparaboina PhD , Mohammed Nasar Ibrahim PhD , Mohammed Abdul Rasheed , Jiwon Baek , Danilo Iannetta MD , Jay Chhablani MD

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Abstract

Age-related macular degeneration (AMD) is the leading cause of central visual impairment in the elderly. The exact pathophysiological mechanisms for AMD remain uncertain. Several studies suggest that choroidal abnormalities and alterations are critical in AMD progression. The transition from manual to automated segmentation and binarization techniques has resulted in accurate and precise measurements of different choroidal parameters. These qualitative and quantitative parameters, known as choroidal imaging biomarkers, have advanced from basic vertical subfoveal choroidal thickness to more intricate 3-dimensional choroidal reconstruction methods in the last decade. Therefore, a comprehensive evaluation of choroidal metrics may investigate valuable insights into AMD, potentially guiding the future development of customized therapeutic strategies and personalized patient care in AMD management. We describe the role of different choroidal biomarkers in evaluating patients with AMD and their contribution to management.

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老年性黄斑变性的脉络膜生物标志物。

老年性黄斑变性（AMD）是导致老年人中心视力受损的主要原因。AMD发病的确切病理生理机制仍不确定。多项研究表明，脉络膜异常和改变是导致老年黄斑变性的关键因素。从手动到自动分割和二值化技术的转变，使得不同脉络膜参数的测量更加精确。这些定性和定量参数被称为脉络膜成像生物标志物，在过去十年中，已从基本的垂直眼底脉络膜厚度发展到更复杂的三维脉络膜重建方法。因此，对脉络膜指标的全面评估可以深入了解 AMD，为未来开发定制化治疗策略和 AMD 管理中的个性化患者护理提供潜在指导。我们介绍了不同脉络膜生物标志物在评估 AMD 患者中的作用及其对管理的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Survey of ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.00%

发文量

138

审稿时长

14.8 weeks

期刊介绍： Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.