Long non-coding RNA LINC-PINT is associated with favorable prognosis in cancer patients: a systematic review and meta-analysis.

IF 1.5 4区医学 Q4 ONCOLOGY Translational cancer research Pub Date : 2024-09-30 Epub Date: 2024-09-19 DOI:10.21037/tcr-24-627

Nayoung Han, Hyun Min Koh

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Abstract

Background: There is growing evidence that long non-coding RNA long iatrogenic non-protein-coding RNA p53-induced transcript (LINC-PINT) is highly expressed in cancer tissue and is associated with the prognosis of cancer patients. The present study systematically analyzed the prognostic significance of LINC-PINT expression in cancer patients. We aimed to reveal the association between LINC-PINT expression and survival in cancer patients.

Methods: We collected eligible studies through the PubMed, Embase, and Cochrane library searches until February 1, 2024. We collected the following data from the enrolled studies: first author, publication year, country, cancer type, case number, cancer stage, detection method and cut-off value of LINC-PINT expression, follow-up period, and survival outcome. The prognostic significance of LINC-PINT expression was evaluated by conducting a meta-analysis. StataSE17 (Stata, College Station, TX, USA) was used for all analyses.

Results: Eleven eligible studies with 2,876 cancer patients were collected. The pooled results revealed that LINC-PINT expression was associated with favorable overall survival (OS) and disease-free survival (DFS) in cancer patients [for OS, hazard ratio (HR) =0.72, 95% confidence interval (CI): 0.64-0.80, P<0.001; for DFS, HR =0.70, 95% CI: 0.60-0.82, P<0.001].

Conclusions: LINC-PINT expression was associated with favorable OS and DFS, and it may serve as a valuable prognostic marker in cancer patients.

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长非编码 RNA LINC-PINT 与癌症患者的良好预后相关：一项系统综述和荟萃分析。

背景：越来越多的证据表明，长非编码RNA长先天性非蛋白编码RNA p53诱导转录本（LINC-PINT）在癌症组织中高表达，并与癌症患者的预后有关。本研究系统分析了 LINC-PINT 在癌症患者中表达的预后意义。我们的目的是揭示 LINC-PINT 表达与癌症患者生存之间的关系：我们通过PubMed、Embase和Cochrane图书馆检索，收集了截至2024年2月1日符合条件的研究。我们收集了入选研究的以下数据：第一作者、发表年份、国家、癌症类型、病例数、癌症分期、LINC-PINT表达的检测方法和临界值、随访时间和生存结果。通过荟萃分析评估了 LINC-PINT 表达的预后意义。所有分析均使用StataSE17（Stata，College Station，TX，USA）：结果：共收集到 11 项符合条件的研究，2,876 名癌症患者。汇总结果显示，LINC-PINT的表达与癌症患者良好的总生存期（OS）和无病生存期（DFS）相关[OS的危险比（HR）=0.72，95%置信区间（CI）：0.64-0.80，PC结论：LINC-PINT的表达与癌症患者良好的总生存期（OS）和无病生存期（DFS）相关]：LINC-PINT的表达与良好的OS和DFS相关，可作为癌症患者有价值的预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational cancer research ONCOLOGY-

CiteScore

2.10

自引率

0.00%

发文量

252

期刊介绍： Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.