Ying Liu, Mengxia Zhu, Xiaoqin Yan, Mu Li, Yan Xiang
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引用次数: 0
Abstract
Purpose: To investigate the long-term effects of repeated low-level red light (RLRL) therapy on the axial length (AL), spherical equivalent (SE), and choroidal parameters.
Methods: Two hundred eight myopic eyes were recruited. The RLRL group included 100 eyes, whereas the control group included 108 eyes. Throughout the one-year follow-up period, changes in AL and SE were recorded for both groups. The RLRL group underwent additional choroidal imaging, and changes in choroidal thickness (CT), choroidal vascularity (CV), and choriocapillaris luminal area (CLA) were assessed before and after RLRL therapy.
Results: During the follow-up period, the changing trends in AL and SE differed significantly between the RLRL and control groups. In the RLRL group, AL decreased at three and six months (both P < 0.05) and returned to pretreatment values at 12 months (P = 0.453). In contrast, AL increased significantly throughout the follow-up period (three, six, and 12 months) in the control group (all P < 0.001). The SE increased significantly during the entire follow-up period in the RLRL group (all P < 0.001), whereas it decreased significantly in the control group (all P < 0.05). Regarding choroidal parameters, significant improvements were observed in CT, CV and CLA throughout the follow-up period (all P < 0.05), and changes in most choroidal parameters were significantly correlated with changes in AL and SE during the follow-up period (all P < 0.05). Furthermore, AL, SE, and most choroidal parameters showed significant correlations between changes at three and 12 months (all P < 0.05).
Conclusions: RLRL therapy significantly improved choroidal blood perfusion and circulation, which may explain the observed slowing or reversal of myopia progression in the RLRL group. Thus RLRL therapy may be a novel and effective method for controlling myopia. Furthermore, the short-term effect of photobiomodulation therapy (i.e., changes at three months) can be used to predict the long-term effects (i.e., changes at 12 months).
Translational relevance: In this study, RLRL therapy showed a significant control effect on the development of axial length and spherical equivalent. RLRL therapy also promoted the choroidal blood perfusion and circulation. RLRL therapy could be a novel and effective method for myopia control.
目的：研究重复低强度红光（RLRL）疗法对轴长（AL）、球面等值（SE）和脉络膜参数的长期影响：方法：招募了 288 只近视眼。方法：共招募了 288 只近视眼，其中红光治疗组 100 只，对照组 108 只。在为期一年的随访期间，记录了两组近视眼AL和SE的变化。RLRL组进行了额外的脉络膜成像，评估了RLRL治疗前后脉络膜厚度（CT）、脉络膜血管（CV）和绒毛膜管腔面积（CLA）的变化：结果：在随访期间，RLRL 组和对照组的 AL 和 SE 变化趋势差异显著。在 RLRL 组，AL 在 3 个月和 6 个月时下降（P 均<0.05），在 12 个月时恢复到治疗前的数值（P = 0.453）。相比之下，对照组的 AL 在整个随访期间（3 个月、6 个月和 12 个月）都明显增加（均 P <0.001）。在整个随访期间，RLRL 组的 SE 明显增加（均 P <0.001），而对照组的 SE 则明显下降（均 P <0.05）。在脉络膜参数方面，CT、CV 和 CLA 在整个随访期间均有显著改善（均 P <0.05），大多数脉络膜参数的变化与 AL 和 SE 在随访期间的变化显著相关（均 P <0.05）。此外，AL、SE和大多数脉络膜参数在3个月和12个月的变化之间存在显著相关性（均P < 0.05）：结论：RLRL疗法明显改善了脉络膜的血液灌注和循环，这可能是RLRL组近视进展减缓或逆转的原因。因此，RLRL疗法可能是控制近视的一种新颖而有效的方法。此外，光生物调节疗法的短期效果（即三个月时的变化）可用于预测长期效果（即 12 个月时的变化）：在这项研究中，RLRL疗法对轴向长度和球面等值的发展具有显著的控制作用。RLRL疗法还促进了脉络膜的血液灌注和循环。RLRL疗法可能是一种新型、有效的近视控制方法。
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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