[Perioperative changes of serum interleukin 6 levels in elderly male patients with intertrochanteric fracture].

Xiangxu Chen, Huanyi Zhu, Wei Wu, Chuwei Tian, Liu Shi, Wenbin Fan, Cheng Zhang, Yingjuan Li, Hui Chen, Wei Gao, Yunfeng Rui
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引用次数: 0

Abstract

Objective: To investigate the perioperative changes in serum interleukin 6 (IL-6) levels in elderly male patients with intertrochanteric fractures, and provide evidence for inflammatory control in this patient population.

Methods: The clinical data of 40 male patients aged more than 60 years with intertrochanteric fractures who met the selection criteria between January 2021 and December 2022 were retrospectively analyzed, including 25 non-osteoporosis patients (T value>-2.5, group A) and 15 osteoporosis patients (T value≤-2.5, group B). In addition, 40 healthy men aged more than 60 years old were included as controls (group C) according to the age matching rule. There was no significant difference in age, smoking history, drinking history, body mass index, complications (hypertension and diabetes), alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, and total protein among the 3 groups ( P>0.05). Serum samples were collected from group C subjects and from groups A and B patients preoperatively and on postoperative days 1, 3, 5, and 7. IL-6 levels were measured using ELISA assay. Pearson correlation analysis was used to assess the relationship between IL-6 levels and T values at various time points in groups A and B. Postoperative complications during hospitalization and 1-year mortality rates were recorded for groups A and B.

Results: Preoperative IL-6 levels were significantly higher in groups A and B than in group C ( P<0.05), with group B being significantly higher than group A ( P<0.05). In groups A and B, IL-6 levels increased significantly on postoperative day 1 compared to preoperative levels and then gradually decreased, approaching preoperative levels by postoperative day 7. IL-6 levels in group B were significantly higher than those in group A at all postoperative time points ( P<0.05). Correlation analysis showed that IL-6 levels were negatively correlated with T values at all perioperative time points in all patients from groups A and B ( P<0.05). Complications occurred in 4 patients (16.0%) in group A, including 2 cases of pulmonary infection, 1 case of urinary tract infection, and 1 case of heart failure, and in 3 patients (20.0%) in group B, including 2 cases of pulmonary infection and 1 case of gastrointestinal bleeding. There was no significant difference in the incidence of complications between the two groups ( χ 2=0.104, P=0.747). There were 2 cases (8.0%) and 4 cases (26.7%) died within 1 year after operation in groups A and B, respectively, and there was no significant difference in 1-year mortality rates between the two groups ( χ 2=2.562, P=0.109).

Conclusion: Serum IL-6 levels significantly increase in the early postoperative period in elderly male patients with intertrochanteric fractures, especially in those with osteoporosis. Monitoring the inflammatory state and promptly controlling the inflammatory response during the perioperative period, may reduce complications and improve postoperative survival in this patient population.

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[转子间骨折老年男性患者血清白细胞介素 6 水平的围手术期变化]。
目的研究老年男性转子间骨折患者围手术期血清白细胞介素6(IL-6)水平的变化,为该患者群体的炎症控制提供证据:回顾性分析2021年1月至2022年12月期间符合入选标准的40例60岁以上男性转子间骨折患者的临床资料,包括25例非骨质疏松症患者(T值>-2.5,A组)和15例骨质疏松症患者(T值≤-2.5,B组)。此外,根据年龄匹配规则,40 名 60 岁以上的健康男性被纳入对照组(C 组)。三组患者的年龄、吸烟史、饮酒史、体重指数、并发症(高血压和糖尿病)、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血尿素氮、肌酐和总蛋白均无明显差异(P>0.05)。术前、术后第 1、3、5 和 7 天采集 C 组受试者、A 组和 B 组患者的血清样本。采用 ELISA 法测定 IL-6 水平。采用皮尔逊相关分析评估了 A 组和 B 组不同时间点 IL-6 水平与 T 值之间的关系,并记录了 A 组和 B 组住院期间的术后并发症和 1 年死亡率:A组和B组术前IL-6水平明显高于C组(PPPPχ 2=0.104,P=0.747)。A组和B组分别有2例(8.0%)和4例(26.7%)患者术后1年内死亡,两组1年死亡率无明显差异(χ 2=2.562,P=0.109):结论:老年男性转子间骨折患者术后早期血清IL-6水平明显升高,尤其是骨质疏松症患者。在围手术期监测炎症状态并及时控制炎症反应,可减少并发症的发生,提高这类患者的术后存活率。
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来源期刊
中国修复重建外科杂志
中国修复重建外科杂志 Medicine-Medicine (all)
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0.80
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11334
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