Hypokalaemic myopathy associated with iatrogenic hypercorticism in a cat.

IF 0.7 Q3 VETERINARY SCIENCES Journal of Feline Medicine and Surgery Open Reports Pub Date : 2024-10-10 eCollection Date: 2024-07-01 DOI:10.1177/20551169241273571
Annamaria Tiozzo Ambrosi, Giorgia Lovato, Laura Pintore, Carolina Callegari, Alice Tamborini
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Abstract

Case summary: A 12-year-old castrated male domestic shorthair cat was referred for investigation of lethargy, hindlimb weakness with plantigrade stance and ventroflexion of the neck. The cat was fed a balanced diet and had received methylprednisolone acetate at a dose of 20 mg intramuscularly every 6 months for 6 years. On blood work, severe hypokalaemia and marked elevation of muscle enzymes were noticeable. The findings were suggestive of hypokalaemic myopathy. Urine fractional excretion of potassium (FEk) was moderately high (9.04%), and serum aldosterone was below the reference interval. An adrenocorticotropic hormone (ACTH) stimulation test was compatible with adrenal suppression. Upon hospitalisation, the patient was given intravenous (IV) Ringer lactate solution supplemented with potassium chloride and oral potassium citrate. The serum potassium concentration normalised by the fifth day of hospitalisation; therefore, IV potassium supplementation was suspended. The cat was discharged with oral potassium and the dose was gradually reduced over time. After 4 months, the cat was clinically normal; the serum potassium concentration remained within the normal range and the adrenal glands showed some response to ACTH stimulation. Potassium supplementation was therefore discontinued. One month later, the serum potassium concentration was still within normal limits and at the time of writing (7 months after presentation), no clinical signs had reoccurred.

Relevance and novel information: This report describes a case of hypokalaemic myopathy associated with iatrogenic hypercorticism in a cat. This condition was successfully treated with supplementation of potassium and a complete clinical remission was achieved within 4 months.

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一只猫因先天性皮质功能亢进引起的低钾血症性肌病。
病例摘要:一只 12 岁的阉割雄性家养短毛猫因嗜睡、后肢无力、匍匐和颈部外翻而被转诊就医。该猫饮食均衡,6 年来一直服用醋酸甲泼尼龙,每 6 个月肌肉注射一次,剂量为 20 毫克。血液检查结果显示,该猫患有严重的低钾血症,肌酶明显升高。这些结果提示患者患有低血钾性肌病。尿钾排泄率(FEk)中等偏高(9.04%),血清醛固酮低于参考区间。促肾上腺皮质激素(ACTH)刺激试验与肾上腺抑制相符。入院后,患者接受了补充氯化钾的静脉注射(IV)林格乳酸盐溶液和口服枸橼酸钾。住院第五天,血清钾浓度恢复正常,因此暂停了静脉补钾。猫咪出院时口服了钾,并随着时间的推移逐渐减少了剂量。4 个月后,猫咪的临床症状恢复正常;血清钾浓度仍在正常范围内,肾上腺对促肾上腺皮质激素刺激也有一些反应。因此,钾补充剂被停止使用。一个月后,猫的血清钾浓度仍在正常范围内,在撰写本报告时(发病 7 个月后),临床症状没有再次出现:本报告描述了一例与先天性皮质功能亢进有关的低血钾性肌病。通过补充钾成功治疗了这种病症,并在 4 个月内实现了临床症状的完全缓解。
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来源期刊
CiteScore
1.30
自引率
14.30%
发文量
57
审稿时长
15 weeks
期刊最新文献
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