Astaxanthin compound nutrient improved insulin resistance, hormone levels, embryo quality and pregnancy outcomes in polycystic ovary syndrome patients undergoing in vitro fertilization/intracytoplasmic sperm injection.

IF 1.9 Q3 PHARMACOLOGY & PHARMACY Drug Discoveries and Therapeutics Pub Date : 2024-11-15 Epub Date: 2024-10-18 DOI:10.5582/ddt.2024.01036
Xiayan Fu, Wenli Cao, Feijun Ye, Jialu Bei, Yan Du, Ling Wang
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Abstract

This study aimed to evaluate the effect of astaxanthin compound nutrient (ACN) complementary therapy on pregnancy outcomes in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). This study enrolled 92 patients with PCOS who were continuously supplemented with ACN for three months prior to IVF/ICSI treatment from 2021 to 2023, and selected 92 patients who did not receive the treatment during the same period as controls. Baseline characteristics, ovulation induction outcomes, and pregnancy outcomes were compared between the two groups. In addition, the body mass index (BMI), anti-Müllerian hormone (AMH), antral follicle counting (AFC), fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistant (HOME-IR), and basal sex hormones of the supplementary group patients before and after treatment were compared. The results showed that there were no significant differences in the patient's duration of stimulation, total gonadotropin dose, peak E2 levels, and number of retrieved oocytes between the two groups. However, the number of 2 pronucleus (PN) fertilization, transferable embryos, and high-quality embryos was significantly higher in the ACN group compared with the control group. For both fresh and frozen embryo transplantation, positive pregnancy outcomes increased in PCOS patients who received supplementation of ACN for 3 months. In addition, after 3 months of supplementing with ACN, the patient's BMI, AMH, fasting insulin, HOME-IR, basal luteinising hormone (bLH), and basal testosterone (bT) decreased compared to before treatment. This study suggested that ACN improved insulin resistance, hormone levels, embryo quality and pregnancy outcomes in PCOS patients.

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虾青素复合营养素改善了接受体外受精/卵胞浆内单精子注射的多囊卵巢综合征患者的胰岛素抵抗、激素水平、胚胎质量和妊娠结局。
本研究旨在评估虾青素复合营养素(ACN)辅助疗法对接受体外受精/卵胞浆内单精子注射(IVF/ICSI)的多囊卵巢综合征(PCOS)患者妊娠结局的影响。这项研究招募了 92 名多囊卵巢综合征患者,这些患者在 2021 年至 2023 年期间接受体外受精/卵胞浆内单精子注射治疗前三个月连续补充 ACN,并选择了 92 名同期未接受治疗的患者作为对照组。比较了两组患者的基线特征、促排卵结果和妊娠结果。此外,还比较了辅助组患者治疗前后的体重指数(BMI)、抗穆勒氏管激素(AMH)、前卵泡计数(AFC)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗的稳态模型评估(HOME-IR)和基础性激素。结果显示,两组患者的促性腺激素刺激持续时间、促性腺激素总剂量、E2峰值水平和取卵数无明显差异。然而,与对照组相比,ACN 组的 2 代核(PN)受精、可移植胚胎和优质胚胎的数量明显较高。在新鲜胚胎移植和冷冻胚胎移植中,补充 ACN 3 个月的多囊卵巢综合征患者的阳性妊娠结果均有所增加。此外,补充 ACN 3 个月后,患者的 BMI、AMH、空腹胰岛素、HOME-IR、基础黄体生成素(bLH)和基础睾酮(bT)与治疗前相比均有所下降。这项研究表明,ACN 可改善多囊卵巢综合征患者的胰岛素抵抗、激素水平、胚胎质量和妊娠结局。
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来源期刊
Drug Discoveries and Therapeutics
Drug Discoveries and Therapeutics PHARMACOLOGY & PHARMACY-
CiteScore
3.20
自引率
3.20%
发文量
51
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