Health characteristics associated with persistence of SARS-CoV-2 antibody responses after repeated vaccinations in older persons over time: the Doetinchem cohort study.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2024-10-15 DOI:10.1186/s12979-024-00476-7
Yunus Kuijpers, Joanna Kaczorowska, H Susan J Picavet, Mary-Lène de Zeeuw-Brouwer, Marjan Kuijer, Irene Slits, Esther Gijsbers, Ryanne Rutkens, Lia de Rond, W M Monique Verschuren, Anne-Marie Buisman
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Abstract

Background: Older persons elicit heterogeneous antibody responses to vaccinations that generally are lower than those in younger, healthier individuals. As older age and certain comorbidities can influence these responses we aimed to identify health-related variables associated with antibody responses after repeated SARS-CoV-2 vaccinations and their persistence thereafter in SARS-CoV-2 infection-naïve and previously infected older persons.

Method: In a large longitudinal study of older persons of the general population 50 years and over, a sub-cohort of the longitudinal Doetinchem cohort study (n = 1374), we measured IgG antibody concentrations in serum to SARS-CoV-2 Spike protein (S1) and Nucleoprotein (N). Samples were taken following primary vaccination with BNT162b2 or AZD1222, pre- and post-vaccination with a third and fourth BNT162b2 or mRNA-1273 (Wuhan), and up to a year after a fifth BNT162b2 bivalent (Wuhan/Omicron BA.1) vaccine. Associations between persistence of antibody concentrations over time and age, sex, health characteristics including cardiometabolic and inflammatory diseases as well as a frailty index were tested using univariable and multivariable models.

Results: The booster doses substantially increased anti-SARS-CoV-2 Spike S1 (S1) antibody concentrations in older persons against both the Wuhan and Omicron strains. Older age was associated with decreased antibody persistence both after the primary vaccination series and up to 1 year after the fifth vaccine dose. In infection-naïve persons the presence of inflammatory diseases was associated with an increased antibody response to the third vaccine dose (Beta = 1.53) but was also associated with reduced persistence over the 12 months following the fifth (bivalent) vaccine dose (Beta = -1.7). The presence of cardiometabolic disease was associated with reduced antibody persistence following the primary vaccination series (Beta = -1.11), but this was no longer observed after bivalent vaccination.

Conclusion: Although older persons with comorbidities such as inflammatory and cardiometabolic diseases responded well to SARS-CoV-2 booster vaccinations, they showed a reduced persistence of these responses. This might indicate that especially these more vulnerable older persons could benefit from repeated booster vaccinations.

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与老年人反复接种疫苗后 SARS-CoV-2 抗体持续反应有关的健康特征:Doetinchem 队列研究。
背景:老年人接种疫苗后会产生不同的抗体反应,这些反应通常低于年轻、健康的人。由于老年人的年龄和某些并发症会影响这些反应,我们旨在确定与重复接种 SARS-CoV-2 疫苗后抗体反应有关的健康相关变量,以及未感染过 SARS-CoV-2 和曾感染过 SARS-CoV-2 的老年人此后抗体反应的持续性:在一项大型纵向研究中,我们测量了血清中 SARS-CoV-2 Spike 蛋白 (S1) 和核蛋白 (N) 的 IgG 抗体浓度,这项研究的对象是 50 岁及以上的老年人,是 Doetinchem 纵向队列研究的子队列(n = 1374)。样本是在接种 BNT162b2 或 AZD1222 初次疫苗后、接种第三和第四次 BNT162b2 或 mRNA-1273 疫苗(武汉)前后以及接种第五次 BNT162b2 二价疫苗(武汉/Omicron BA.1)一年后采集的。采用单变量和多变量模型检验了抗体浓度的持续时间与年龄、性别、健康特征(包括心脏代谢疾病和炎症性疾病)以及虚弱指数之间的关系:结果:加强剂量大大提高了老年人抗武汉株和奥米克龙株的抗 SARS-CoV-2 Spike S1(S1)抗体浓度。高龄与初次接种后以及第五剂疫苗接种后一年内抗体持续性下降有关。在感染免疫者中,炎症性疾病的存在与第三剂疫苗抗体反应的增加有关(Beta = 1.53),但也与第五剂(二价)疫苗接种后 12 个月内抗体持续性的降低有关(Beta = -1.7)。存在心脏代谢疾病与接种第一剂疫苗后抗体持续性降低有关(Beta = -1.11),但在接种二价疫苗后不再观察到这种情况:结论:尽管患有炎症和心脏代谢疾病等合并症的老年人对 SARS-CoV-2 加强免疫反应良好,但他们的这些反应的持续性降低了。这可能表明,尤其是这些更易受感染的老年人可以从重复加强免疫中获益。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
期刊最新文献
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