Activation of a Soft Robotic Left Ventricular Phantom Embedded in a Closed-Loop Cardiovascular Simulator: A Computational and Experimental Analysis.

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Engineering and Technology Pub Date : 2024-10-14 DOI:10.1007/s13239-024-00755-w

Nele Demeersseman, Maria Rocchi, Heleen Fehervary, Guillermo Fernández Collazo, Bart Meyns, Libera Fresiello, Nele Famaey

{"title":"Activation of a Soft Robotic Left Ventricular Phantom Embedded in a Closed-Loop Cardiovascular Simulator: A Computational and Experimental Analysis.","authors":"Nele Demeersseman, Maria Rocchi, Heleen Fehervary, Guillermo Fernández Collazo, Bart Meyns, Libera Fresiello, Nele Famaey","doi":"10.1007/s13239-024-00755-w","DOIUrl":null,"url":null,"abstract":"Purpose: Cardiovascular simulators are used in the preclinical testing phase of medical devices. Their reliability increases the more they resemble clinically relevant scenarios. In this study, a physiologically actuated soft robotic left ventricle (SRLV) embedded in a hybrid (in silico- in vitro) simulator of the cardiovascular system is presented, along with its experimental and computational analysis.Methods: A SRLV phantom, developed from a patient's CT scan using polyvinyl alcohol (PVA), is embedded in a hybrid cardiovascular simulator. We present an activation method in which the hydraulic pressure external ( <math> <mrow><msub><mi>P</mi> <mi>e</mi></msub> <mrow><mo>(</mo> <mi>t</mi> <mo>)</mo></mrow> </mrow> </math> ) to the SRLV is continuously adapted to regulate the left ventricular volume ( <math> <mrow><msub><mi>V</mi> <mi>i</mi></msub> <mrow><mo>(</mo> <mi>t</mi> <mo>)</mo></mrow> </mrow> </math> ), considering the geometry and material behavior of the SRLV and the left ventricular pressure ( <math> <mrow><msub><mi>P</mi> <mi>i</mi></msub> <mrow><mo>(</mo> <mi>t</mi> <mo>)</mo></mrow> </mrow> </math> ). This activation method is verified using a finite element (FE) model of the SRLV and validated in the hybrid simulator. Different hemodynamic profiles are presented to test the flexibility of the method.Results: Both the FE model and hybrid simulator could represent the desired in silico data ( <math> <mrow><msub><mi>P</mi> <mi>i</mi></msub> <mrow><mo>(</mo> <mi>t</mi> <mo>)</mo></mrow> </mrow> </math> , <math> <mrow><msub><mi>V</mi> <mi>i</mi></msub> <mrow><mo>(</mo> <mi>t</mi> <mo>)</mo></mrow> </mrow> </math> ) with the implemented activation method, with deviations below 8.09% in the FE model and mainly < 10% errors in the hybrid simulator. Only two measurements out of 32 exceeded the 10% threshold due to simulator setup limitations.Conclusion: The activation method effectively allows to represent various pressure-volume loops, as verified numerically, and validated experimentally in the hybrid simulator. This work presents a high-fidelity platform designed to simulate cardiovascular conditions, offering a robust foundation for future testing of cardiovascular medical devices under physiological conditions.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular Engineering and Technology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s13239-024-00755-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Cardiovascular simulators are used in the preclinical testing phase of medical devices. Their reliability increases the more they resemble clinically relevant scenarios. In this study, a physiologically actuated soft robotic left ventricle (SRLV) embedded in a hybrid (in silico- in vitro) simulator of the cardiovascular system is presented, along with its experimental and computational analysis.

Methods: A SRLV phantom, developed from a patient's CT scan using polyvinyl alcohol (PVA), is embedded in a hybrid cardiovascular simulator. We present an activation method in which the hydraulic pressure external ( $P_{e} (t)$ ) to the SRLV is continuously adapted to regulate the left ventricular volume ( $V_{i} (t)$ ), considering the geometry and material behavior of the SRLV and the left ventricular pressure ( $P_{i} (t)$ ). This activation method is verified using a finite element (FE) model of the SRLV and validated in the hybrid simulator. Different hemodynamic profiles are presented to test the flexibility of the method.

Results: Both the FE model and hybrid simulator could represent the desired in silico data ( $P_{i} (t)$ , $V_{i} (t)$ ) with the implemented activation method, with deviations below 8.09% in the FE model and mainly < 10% errors in the hybrid simulator. Only two measurements out of 32 exceeded the 10% threshold due to simulator setup limitations.

Conclusion: The activation method effectively allows to represent various pressure-volume loops, as verified numerically, and validated experimentally in the hybrid simulator. This work presents a high-fidelity platform designed to simulate cardiovascular conditions, offering a robust foundation for future testing of cardiovascular medical devices under physiological conditions.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

嵌入闭环心血管模拟器的软机器人左心室模型的激活：计算与实验分析

目的：心血管模拟器用于医疗设备的临床前测试阶段。模拟器与临床相关场景越相似，其可靠性就越高。本研究介绍了嵌入心血管系统混合（硅体-体外）模拟器中的生理促动软机器人左心室（SRLV）及其实验和计算分析：SRLV模型是利用聚乙烯醇（PVA）从病人的CT扫描中提取的，它被嵌入到一个混合心血管模拟器中。我们提出了一种激活方法，在这种方法中，考虑到 SRLV 的几何形状和材料行为以及左心室压力 ( P i ( t ) ) ，SRLV 外部的液压 ( P e ( t ) ) 不断调整以调节左心室容积 ( V i ( t ) ) 。这种激活方法使用 SRLV 的有限元（FE）模型进行了验证，并在混合模拟器中进行了验证。为了测试该方法的灵活性，我们展示了不同的血液动力学曲线：结果：有限元（FE）模型和混合模拟器都能用实施的激活方法表示所需的硅学数据（P i ( t ) , V i ( t ) ），FE 模型的偏差低于 8.09%，主要是结论：活化法可以有效地表示各种压力-容积循环，这在混合模拟器中得到了数值验证和实验验证。这项工作展示了一个旨在模拟心血管状况的高保真平台，为未来在生理条件下测试心血管医疗设备奠定了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cardiovascular Engineering and Technology Engineering-Biomedical Engineering

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Cardiovascular Engineering and Technology is a journal publishing the spectrum of basic to translational research in all aspects of cardiovascular physiology and medical treatment. It is the forum for academic and industrial investigators to disseminate research that utilizes engineering principles and methods to advance fundamental knowledge and technological solutions related to the cardiovascular system. Manuscripts spanning from subcellular to systems level topics are invited, including but not limited to implantable medical devices, hemodynamics and tissue biomechanics, functional imaging, surgical devices, electrophysiology, tissue engineering and regenerative medicine, diagnostic instruments, transport and delivery of biologics, and sensors. In addition to manuscripts describing the original publication of research, manuscripts reviewing developments in these topics or their state-of-art are also invited.