Exploring the world of small proteins in plant biology and bioengineering.

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY Trends in Genetics Pub Date : 2024-10-14 DOI:10.1016/j.tig.2024.09.004

Louise Petri, Anne Van Humbeeck, Huanying Niu, Casper Ter Waarbeek, Ashleigh Edwards, Maurizio Junior Chiurazzi, Ylenia Vittozzi, Stephan Wenkel

引用次数: 0

Abstract

Small proteins are ubiquitous in all kingdoms of life. MicroProteins, initially characterized as small proteins with protein interaction domains that enable them to interact with larger multidomain proteins, frequently modulate the function of these proteins. The study of these small proteins has contributed to a greater comprehension of protein regulation. In addition to sequence homology, sequence-divergent small proteins have the potential to function as microProtein mimics, binding to structurally related proteins. Moreover, a multitude of other small proteins encoded by short open reading frames (sORFs) and peptides, derived from diverse sources such as long noncoding RNAs (lncRNAs) and miRNAs, contribute to a variety of biological processes. The potential of small proteins is evident, offering promising avenues for bioengineering that could revolutionize crop performance and reduce reliance on agrochemicals in future agriculture.

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探索植物生物学和生物工程中的小蛋白质世界。

小蛋白质在生命的各个领域无处不在。微小蛋白质最初被描述为具有蛋白质相互作用结构域的小蛋白质，这些结构域使它们能够与较大的多结构域蛋白质相互作用，并经常调节这些蛋白质的功能。对这些小蛋白的研究有助于加深对蛋白质调控的理解。除了序列同源性外，序列差异小蛋白还有可能作为微蛋白模拟物，与结构相关的蛋白结合。此外，由短开放阅读框（sORFs）和肽编码的大量其他小蛋白，来自长非编码 RNAs（lncRNAs）和 miRNAs 等不同来源，有助于各种生物过程。小蛋白质的潜力显而易见，为生物工程提供了大有可为的途径，可彻底改变作物的性能，减少未来农业对农用化学品的依赖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.

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