Understanding host's response to staphylococcal scalded skin syndrome.

IF 2.4 4区医学 Q1 PEDIATRICS Acta Paediatrica Pub Date : 2024-10-16 DOI:10.1111/apa.17462

Glykeria Rouva, Eleni Vergadi, Konstantinos Krasagakis, Emmanouil Galanakis

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Abstract

Aim: The aim of this review was to summarise the current knowledge on host-related factors that contribute to the development and severity of staphylococcal scalded skin syndrome (SSSS) in children.

Methods: A comprehensive assessment and analysis of the existing literature on SSSS clinical features, pathogenesis and susceptibility factors.

Results: SSSS is a blistering skin disease caused by circulating exfoliative toxins (ETs) of Staphylococcus aureus (S. aureus), almost exclusively affecting infants, young children and immunocompromised individuals. ETs possess serine protease activity and target desmoglein-1 (Dsg-1) in the superficial epidermis. While the role of S. aureus ETs and site of action are well-described, other host factors such as impaired immune responses to ETs, poor renal clearance and genetic factors are crucial for the onset of and/or the severity of SSSS in children.

Conclusion: The fate of desmosomal fractions after cleavage by ETs, as well as the role of dermal inflammatory cell infiltrates remain to be elucidated.

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了解宿主对葡萄球菌烫伤皮肤综合征的反应。

目的：本综述旨在总结目前关于导致儿童葡萄球菌皮肤烫伤综合征（SSSS）发生和严重程度的宿主相关因素的知识：方法：全面评估和分析有关 SSSS 临床特征、发病机制和易感因素的现有文献：SSSS是由金黄色葡萄球菌（S. aureus）的循环脱落毒素（ETs）引起的一种水疱性皮肤病，几乎只影响婴儿、幼儿和免疫力低下的人。ETs 具有丝氨酸蛋白酶活性，靶向表皮浅层的去甲斑鸠蛋白-1（Dsg-1）。虽然金黄色葡萄球菌 ETs 的作用和作用部位已被详细描述，但其他宿主因素，如对 ETs 的免疫反应受损、肾脏清除能力差和遗传因素，对儿童 SSSS 的发病和/或严重程度至关重要：结论：ETs裂解后脱丝体碎片的去向以及真皮炎症细胞浸润的作用仍有待阐明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries