Association of Androgenetic Alopecia with Metabolic Syndrome.

Hina Farooq Qureshi, Aisha Akhtar, Asmatullah Kakar, Syeda Sakina, Sania Irum, Nasira Nasr
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Abstract

Objective: To determine the association of androgenetic alopecia (AGA) with metabolic syndrome (MetS) in either gender.

Study design: Descriptive study. Place and Duration of the Study: OPD complex, Pak Emirates Military Hospital, Rawalpindi, Pakistan, from February to August 2021.

Methodology: The study included a total of 90 patients who met the specified criteria for enrolment. Each group (case and control) contains 45 patients. Diagnosis of androgenetic 2 alopecia was done clinically and grading was based on the Norwood-Hamilton classification in males and Ludwig classification in females. Body mass index (BMI) was calculated and blood pressure was measured for all enrolled patients. Following an overnight fasting period, blood samples were collected from each patient to measure clinical parameters including triglycerides (TGs), fasting blood sugar (FBS), and high-density lipoprotein (HDL) levels.

Results: There were 85.6% males and 4.4% females with a mean age of 43.38 years. Out of which, 34.4% and 15.6% of patients fell in severity 1 and severity 2 Class. Patients were stratified on the basis of AGA with respect to TGs, FBS, HDL, and BMI. The p-value was significant when stratified on the basis of BMI, FBS, and HDL except TGs. Odd ratio of both groups on the basis of (MetS) 8.1. Odd ratio between androgenic alopecia and metabolic syndrome was of 2.4.

Conclusion: An association existed between androgenetic alopecia and metabolic syndrome indicating the potential benefit of early MetS screening for individuals with androgenic alopecia. This proactive approach could help prevent unforeseen complications through timely lifestyle adjustments.

Key words: Metabolic syndrome, Androgenic alopecia, Cholesterol, Triglycerides.

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雄激素性脱发与代谢综合征的关系
研究目的研究设计:描述性研究。研究地点和时间:2021 年 2 月至 8 月,巴基斯坦拉瓦尔品第 Pak Emirates 军事医院综合门诊:研究共包括 90 名符合规定入组标准的患者。每组(病例组和对照组)包含 45 名患者。雄激素性 2 型脱发的诊断由临床完成,男性根据诺伍德-汉密尔顿分类法进行分级,女性根据路德维希分类法进行分级。所有入组患者均计算了体重指数(BMI),并测量了血压。经过一夜禁食后,收集每位患者的血液样本,以测量临床参数,包括甘油三酯(TGs)、空腹血糖(FBS)和高密度脂蛋白(HDL)水平:男性占 85.6%,女性占 4.4%,平均年龄为 43.38 岁。其中 34.4% 和 15.6% 的患者属于严重程度 1 级和严重程度 2 级。根据 AGA 对患者的总胆固醇、血脂、高密度脂蛋白和体重指数进行了分层。根据 BMI、FBS 和 HDL 进行分层时,除 TGs 外,P 值均显著。两组人在(MetS)基础上的奇异比率为 8.1。雄激素性脱发与代谢综合征的奇异比为 2.4:雄激素性脱发与代谢综合征之间存在关联,这表明对雄激素性脱发患者进行早期代谢综合征筛查具有潜在的益处。这种积极主动的方法有助于通过及时调整生活方式来预防不可预见的并发症:代谢综合征 雄性激素脱发 胆固醇 甘油三酯
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