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Application of Multi-Slice Spiral CT Renal Angiography Combined with Intraoperative Ultrasound in Laparoscopic Partial Nephrectomy. 多切片螺旋 CT 肾血管造影结合术中超声在腹腔镜肾部分切除术中的应用
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1645
Tao Ma, Wentao Wang, Ke Zhang, Wenzeng Yang, Zhen-Yu Cui

This study aimed to evaluate the clinical significance of multi-slice spiral CT renal angiography combined with intraoperative ultrasound in laparoscopic partial nephrectomy. Eighty patients were seen at the Affiliated Hospital of Hebei University from January 2021 to December 2022. The patients were divided into two groups, the experimental group and the control group, with 40 cases in each group. The experimental group received laparoscopic partial nephrectomy combined with intraoperative ultrasound, while the control group received only conventional laparoscopic partial nephrectomy. The experimental group had significantly shorter operative time and intraoperative thermal ischaemia time (p <0.05) and had significant advantage in the detection of microscopic cancer foci (p = 0.04). The experimental group also had significantly lower of positive rate of postoperative incisal margin (p = 0.01). The experimental group had significantly lower of recurrence rate (p = 0.03). The study concluded that multi-slice spiral CT renal angiography combined with intraoperative ultrasound boasts various benefits in the treatment of patients with renal cell carcinoma, it is safe and effective with no significant impact on renal function. Key Words: CT renal angiography, Intraoperative ultrasound, Laparoscopic partial nephrectomy, Renal cancer.

本研究旨在评估多层螺旋CT肾血管造影联合术中超声在腹腔镜肾部分切除术中的临床意义。河北大学附属医院于 2021 年 1 月至 2022 年 12 月收治了 80 例患者。患者分为两组,即实验组和对照组,每组40例。实验组接受结合术中超声的腹腔镜肾部分切除术,而对照组仅接受传统的腹腔镜肾部分切除术。实验组的手术时间和术中热缺血时间明显更短(P
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引用次数: 0
From Dissertation to Original Paper: A Journey Towards Quality and Standards in Research. 从论文到原创论文:研究质量与标准之旅。
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1527
Khalid Masud Gondal

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引用次数: 0
Modified Double-Tract Reconstruction in Gastrointestinal Reconstruction after Proximal Gastrectomy. 近端胃切除术后胃肠道重建中的改良双牵引重建术
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1632
Yingying Li, Jian Wu, Ming Han, Wenbin Li, Zhibin Bi

Objective: To determine the clinical efficacy and safety of modified double-channel anastomosis for digestive tract reconstruction in proximal gastrectomy for early gastric cancer (EGC).

Study design: Case series. Place and Duration of the Study: Department of Gastrointestinal Surgery, Heji Hospital, Changzhi Medical College, Shanxi, China, from January to November 2022.

Methodology: Based on inclusion and exclusion criteria, this study included a total of 21 patients with oesophagogastric junction cancer or proximal gastric cancer who underwent laparoscopic proximal gastrectomy with modified double-channel anastomosis. After resection of the proximal stomach, the remaining stomach was shaped into a tube. The distal end of the oesophagus was anastomosed to the jejunum. The jejunum was anastomosed 10-15 cm from the oesophagojejunostomy site laterally to the anterior wall of the stomach 3 cm from the gastric remnant. General data including operative time, anastomosis time, intraoperative blood loss, time to oral intake, length of hospital stay, and postoperative complications were evaluated. Postoperative gastroscopy and gastrointestinal imaging were performed to assess the residual stomach motility and anti-reflux effect.

Results: All twenty-one patients underwent modified double-channel anastomosis. The mean operation time was 254 (211 - 297) minutes. Mean reconstruction time was 65 (60 - 70) minutes. A mean of 19 (15 - 29) lymph nodes were cleared. Mean intraoperative blood loss was 86 (78.5-105ml). Mean time to oral intake was 6 (5 - 6.5) days. Postoperatively, there were two cases of pulmonary infection. There was no occurrence of anastomotic stenosis, anastomotic bleeding, or leakage. Gastrointestinal contrast study at 6 months postoperatively revealed reduced gastrointestinal motility in three cases and good residual gastric motility observed in the remaining patients. Gastroscopic examination at 6 months postoperatively revealed only one case of reflux oesophagitis.

Conclusion: Modified double-channel anastomosis for proximal gastrectomy is safe and feasible. It provides a good anti-reflux effect and gastric emptying function without increasing the risk of postoperative complications.

Key words: Adenocarcinoma of the oesophagogastric junction, Upper gastric carcinoma, Proximal gastrectomy, Double-tract reconstruction.

研究目的研究设计:病例系列。研究地点和时间:山西省长治医学院附属和济医院胃肠外科,2022年1月至11月:根据纳入和排除标准,本研究共纳入21例食管胃交界癌或近端胃癌患者,他们均接受了腹腔镜近端胃切除术,并进行了改良双通道吻合术。切除近端胃后,剩余的胃被塑造成管状。食道远端与空肠吻合。空肠在距食管空肠吻合口 10-15 厘米处与胃前壁吻合,吻合口在距残胃 3 厘米处。对手术时间、吻合时间、术中失血量、口服时间、住院时间和术后并发症等一般数据进行了评估。术后还进行了胃镜检查和胃肠造影,以评估残胃蠕动和抗反流效果:所有21名患者均接受了改良双通道吻合术。平均手术时间为 254(211 - 297)分钟。平均重建时间为 65(60 - 70)分钟。平均清除了19(15 - 29)个淋巴结。术中平均失血量为 86(78.5-105 毫升)。平均口服时间为 6(5 - 6.5)天。术后有两例肺部感染。没有发生吻合口狭窄、吻合口出血或渗漏。术后 6 个月的胃肠道造影检查显示,3 例患者的胃肠道蠕动减弱,其余患者的残余胃蠕动良好。术后 6 个月的胃镜检查仅发现一例反流性食管炎:结论:改良双通道吻合术用于近端胃切除术是安全可行的。结论:改良双通道吻合术用于近端胃切除术是安全可行的,它具有良好的抗反流效果和胃排空功能,同时不会增加术后并发症的风险:食管胃交界腺癌 上胃癌 近端胃切除术 双通道重建
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引用次数: 0
Outcome Analysis of Transperitoneal Laparoscopic Nephrectomy in Children: Experience from a Developing Country. 儿童经腹腔镜肾切除术的结果分析:发展中国家的经验。
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1596
Ghulam Mujtaba Zafar, Muhammad Zaheer, Fawad Humayun Akhtar, Sadia Ghias

Objective: To analyse the outcome of laparoscopic nephrectomy among children.

Study design: An observational study. Place and Duration of the Study: Department of Paediatric Urology, Children's Hospital Lahore, from September 2021 to June 2023.

Methodology: During the study, 100 children aged 5-180 months were included. Data regarding age, gender, cause, side, intraoperative and postoperative outcomes such as number of ports, estimated blood loss, need of transfusion, operative time, hospital stay, analgaesia requirement and complications were recorded. Data were collected through proforma which were entered and analysed through computer software SPSS version 16.0.

Results: Among 100 children, 58.0% were males and the mean age was 79.54 ± 4.427 months while the major cause of laparoscopic nephrectomy was PUJO (Pelvi-Ureteric Junction Obstruction) for 47.0% of children. The mean blood loss was 19.93 ± 65.556 ml and the majority of the children (96.0%) did not require blood transfusion. The mean operative time was 125.31 ± 43.365 minutes and the mean hospital stay was 2.82 ± 1.258 days. Most of the children (90.0%) had no complications while 3.0% had ileus which was managed conservatively and 3.0% were converted to open surgery while 4.0% had wound infection.

Conclusion: Laparoscopic nephrectomy is an effective technique with regard to insignificant blood loss, operative time, hospital stay, and rate of complications.

Key words: Laparoscopy, Nephrectomy, Children, Operative time, Hospital stay, Complications.

研究目的分析儿童腹腔镜肾切除术的结果:观察性研究。研究地点和时间:拉合尔儿童医院小儿泌尿科,2021 年 9 月至 2023 年 6 月:研究期间,共纳入 100 名 5-180 个月大的儿童。记录了有关年龄、性别、病因、病侧、术中和术后结果(如孔数、估计失血量、输血需求、手术时间、住院时间、肛门指诊需求和并发症)的数据。数据通过表格收集,并通过 SPSS 16.0 版计算机软件进行输入和分析:在100名儿童中,58.0%为男性,平均年龄为(79.54 ± 4.427)个月,47.0%的儿童腹腔镜肾切除术的主要原因是PUJO(肾盂输尿管连接处梗阻)。平均失血量为 19.93 ± 65.556 毫升,大多数患儿(96.0%)无需输血。平均手术时间为 125.31 ± 43.365 分钟,平均住院时间为 2.82 ± 1.258 天。大多数患儿(90.0%)没有出现并发症,3.0%的患儿出现回肠梗阻,但得到了保守治疗,3.0%的患儿转为开放手术,4.0%的患儿出现伤口感染:结论:腹腔镜肾切除术是一种有效的技术,其失血量、手术时间、住院时间和并发症发生率都很低:腹腔镜 肾切除术 儿童 手术时间 住院时间 并发症
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引用次数: 0
Positioning for Emergency Laparoscopic Splenectomy for Traumatic Splenic Rupture. 创伤性脾破裂急诊腹腔镜脾切除术的定位。
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1627
Hongjun Haung, Zhiqiang Haung, Ruofei Xiong, Xingcheng Meng, Ju Zhang

Objective: To determine whether the right-lateral decubitus or supine position is superior for emergency laparoscopy for traumatic splenic rupture.

Study design: Descriptive study. Place and Duration of the Study: Department of General Surgery, Central Hospital of Shaoxing, Affiliated Hospital of China Medical University, Zhejiang, China, from January 2015 to December 2022.

Methodology: Clinical data of 96 patients who underwent laparoscopic surgery (LS) for traumatic splenic rupture were analysed. The patients were divided into two groups according to surgical position. Group A (n = 42) patients were placed in the right-lateral decubitus position and Group B (n = 54) patients were placed in the supine position. The operation time, intraoperative blood loss, conversion to laparotomy rate, postoperative length of hospital stay, and complications rates were compared between the two groups.

Results: Compared with Group B, Group A had a shorter operation time (145.5 ± 24.4 min vs. 169.0 ± 15.3 min, p = 0.0001), less intraoperative blood loss (75.3 ± 35.3 ml vs. 110.3 ± 50.6 ml, p = 0.0002), fewer conversions to laparotomy (2.4% vs. 16.7%, p = 0.023), fewer cases of postoperative pancreatic leakage (7.1% vs. 24.1%, p = 0.027), and fewer complications (23.8% vs. 53.7%, p = 0.003); all differences were significant. There was no statistically significant difference in the postoperative length of hospital stay, hospital cost, or rate of complications such as fever, postoperative abdominal infection, postoperative bleeding or venous thrombosis between the two groups.

Conclusion: For patients with traumatic splenic rupture, the right-lateral decubitus position is best for LS.

Key words: Laparoscopy, Traumatic splenic rupture, Splenectomy, Surgical position.

研究目的研究设计:描述性研究。研究地点和时间:中国医科大学附属绍兴市中心医院普外科,浙江,2015年1月至2022年12月:方法:分析 96 例接受腹腔镜手术(LS)治疗外伤性脾破裂患者的临床资料。根据手术体位将患者分为两组。A 组(42 人)患者取右侧卧位,B 组(54 人)患者取仰卧位。比较了两组患者的手术时间、术中失血量、转为开腹手术率、术后住院时间和并发症发生率:结果:与 B 组相比,A 组手术时间更短(145.5 ± 24.4 分钟 vs. 169.0 ± 15.3 分钟,P = 0.0001),术中失血量更少(75.3 ± 35.3 毫升 vs. 110.3 ± 50.6 毫升,P = 0.0002)、较少转为开腹手术(2.4% vs. 16.7%,p = 0.023)、较少术后胰漏(7.1% vs. 24.1%,p = 0.027)和较少并发症(23.8% vs. 53.7%,p = 0.003);所有差异均显著。两组患者的术后住院时间、住院费用以及发热、术后腹腔感染、术后出血或静脉血栓等并发症的发生率均无统计学差异:结论:对于外伤性脾破裂的患者,右侧卧位是进行腹腔镜手术的最佳体位:腹腔镜 外伤性脾破裂 脾切除术 手术体位
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引用次数: 0
Association of Vitamin D with Haematological Inflammatory Indices in Patients with Back Pain. 维生素 D 与背痛患者血液炎症指标的关系
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1557
Yasemin Ozkan, Mahmut Alpayci, Veysel Delen

Objective: To assess the relationship between vitamin D and haematological inflammatory indices (HII) in chronic low back pain (CLBP) patients.

Study design: Descriptive study. Place and Duration of the Study: Harran University Hospital, Sanliurfa, Turkiye, between September 2023 and February 2024.

Methodology: A total of 100 CLBP patients were divided into three groups according to their vitamin D levels as deficiency (<20 µg/L), insufficiency (20-30 µg/L), and sufficiency (30-80 µg/L). Demographic characteristics, serum parameters, and HII were compared among the three groups. Additionally, the association between vitamin D and other parameters were investigated.

Results: The three groups were similar in terms of age (p = 0.640), gender distribution (p = 0.057), body mass index (BMI, p = 0.855), C-reactive protein (CRP, p = 0.965), leucocyte count (p = 0.979), neutrophil count (p = 0.525), lymphocyte count (p = 0.246), monocyte count (p = 0.485), platelet count (p = 0.878), and HII including neutrophil-to-lymphocyte ratio (NLR, p = 0.335), monocyte-to- lymphocyte ratio (MLR, p = 0.227), platelet-to-lymphocyte ratio (PLR) (p = 0.898), neutrophil-to-lymphocyte*platelet ratio (NLPR, p = 0.543), systemic inflammatory index (SII, p = 0.300), systemic inflammatory response index (SIRI, p = 0.187), and aggregate index of systemic inflammation (AISI, p = 0.219). No significant correlation was found between vitamin D concentration and other parameters (p >0.05).

Conclusion: The coexistence of vitamin D deficiency and increased HII may accompany inflammatory conditions. However, no significant association was found between vitamin D level and HII in non-inflammatory CLBP.

Key words: Inflammation, Low back pain, Neutrophil, Complete blood count, Vitamin D.

研究目的评估慢性腰背痛(CLBP)患者体内维生素 D 与血液炎症指数(HII)之间的关系:描述性研究。研究地点和时间研究时间:2023 年 9 月至 2024 年 2 月,土耳其桑尼乌尔法哈兰大学医院:根据维生素 D 缺乏水平将 100 名 CLBP 患者分为三组:三组患者在年龄(P = 0.640)、性别分布(P = 0.057)、体重指数(BMI,P = 0.855)、C 反应蛋白(CRP,P = 0.965)、白细胞计数(P = 0.979)、中性粒细胞计数(p = 0.525)、淋巴细胞计数(p = 0.246)、单核细胞计数(p = 0.485)、血小板计数(p = 0.878),以及包括中性粒细胞与淋巴细胞比率(NLR,p = 0.335)、单核细胞与淋巴细胞比值(MLR,p = 0.227)、血小板与淋巴细胞比值(PLR)(p = 0.898)、中性粒细胞与淋巴细胞*血小板比值(NLPR,p = 0.543)、全身炎症指数(SII,p = 0.300)、全身炎症反应指数(SIRI,p = 0.187)和全身炎症综合指数(AISI,p = 0.219)。维生素 D 浓度与其他参数之间无明显相关性(P >0.05):结论:维生素 D 缺乏和 HII 增高可能同时存在于炎症中。结论:维生素 D 缺乏与 HII 增高可能同时存在于炎症中,但在非炎症性腰背痛患者中,维生素 D 水平与 HII 之间并无明显关联:炎症 腰背痛 中性粒细胞 全血细胞计数 维生素 D
{"title":"Association of Vitamin D with Haematological Inflammatory Indices in Patients with Back Pain.","authors":"Yasemin Ozkan, Mahmut Alpayci, Veysel Delen","doi":"10.29271/jcpsp.2024.11.1557","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.11.1557","url":null,"abstract":"<p><strong>Objective: </strong>To assess the relationship between vitamin D and haematological inflammatory indices (HII) in chronic low back pain (CLBP) patients.</p><p><strong>Study design: </strong>Descriptive study. Place and Duration of the Study: Harran University Hospital, Sanliurfa, Turkiye, between September 2023 and February 2024.</p><p><strong>Methodology: </strong>A total of 100 CLBP patients were divided into three groups according to their vitamin D levels as deficiency (<20 µg/L), insufficiency (20-30 µg/L), and sufficiency (30-80 µg/L). Demographic characteristics, serum parameters, and HII were compared among the three groups. Additionally, the association between vitamin D and other parameters were investigated.</p><p><strong>Results: </strong>The three groups were similar in terms of age (p = 0.640), gender distribution (p = 0.057), body mass index (BMI, p = 0.855), C-reactive protein (CRP, p = 0.965), leucocyte count (p = 0.979), neutrophil count (p = 0.525), lymphocyte count (p = 0.246), monocyte count (p = 0.485), platelet count (p = 0.878), and HII including neutrophil-to-lymphocyte ratio (NLR, p = 0.335), monocyte-to- lymphocyte ratio (MLR, p = 0.227), platelet-to-lymphocyte ratio (PLR) (p = 0.898), neutrophil-to-lymphocyte*platelet ratio (NLPR, p = 0.543), systemic inflammatory index (SII, p = 0.300), systemic inflammatory response index (SIRI, p = 0.187), and aggregate index of systemic inflammation (AISI, p = 0.219). No significant correlation was found between vitamin D concentration and other parameters (p >0.05).</p><p><strong>Conclusion: </strong>The coexistence of vitamin D deficiency and increased HII may accompany inflammatory conditions. However, no significant association was found between vitamin D level and HII in non-inflammatory CLBP.</p><p><strong>Key words: </strong>Inflammation, Low back pain, Neutrophil, Complete blood count, Vitamin D.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Diagnosis of Angioimmunoblastic T-Cell Lymphoma and Lung Neuro-endocrine Cancer in a Patient. 一名患者被同步诊断为血管免疫母细胞 T 细胞淋巴瘤和肺神经内分泌癌
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1656
Guangquan Zhou, Rong Chen

Null.

无效。
{"title":"Synchronous Diagnosis of Angioimmunoblastic T-Cell Lymphoma and Lung Neuro-endocrine Cancer in a Patient.","authors":"Guangquan Zhou, Rong Chen","doi":"10.29271/jcpsp.2024.11.1656","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.11.1656","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Small-Dose Esketamine on Postoperative Analgaesia and Sleep Quality in Patients with Total Hip Replacement. 小剂量艾司他敏对全髋关节置换术患者术后肛门不适和睡眠质量的影响
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1640
Qiufeng Wei, Sisi Feng, Weixin Dai, Cheng Xin Lin, Wen Zheng He

Objective: To determine the effect of esketamine in patient-controlled analgaesia after hip replacement on postoperative pain and improve sleep quality in patients.

Study design: Randomised double-blind study. Place and Duration of the Study: Department of Anaesthesiology, The First Affiliated Hospital of Guangxi Medical University, from March 2021 to May 2022.

Methodology: The research enrolled 72 patients who were subjected to unilateral complete hip replacement surgery utilising jointly administered universal and peripheral nerve-obstructing anaesthetics. A randomised numeric table method was used to allocate patients to either the F-D group (fentanyl combined with dexmedetomidine, n = 34) or the Es-D group (esketamine combined with dexmedetomidine, n = 38). The key outcome indicators included the time to first administration of rescue analgaesic, the dose of rescue analgaesics, and postoperative sleep quality.

Results: Baseline characteristics did not differ between the two groups. The time until postoperative analgaesic rescue medication was considerably shorter for those in the Es-D group (p <0.05). In addition, the Es-D group used significantly fewer rescue analgaesics (p = 0.01). The PSQI score and unpleasant responses (PONV, dizziness, nightmare) did not significantly differ between the two groups (p <0.05). Nevertheless, urine retention occurred in four patients in group F-D but not in group Es-D (p <0.05).

Conclusion: Esketamine produced better analgaesia than fentanyl with fewer side effects after surgery. However, no improvement was observed in sleep quality.

Key words: Arthroplasty, Postoperative analgaesia, Esketamine, Sleep quality, Patient-controlled analgaesia.

研究目的研究设计:随机双盲研究。研究地点和时间:研究地点和时间:广西医科大学第一附属医院麻醉科,2021年3月至2022年5月:研究对象为72例单侧全髋关节置换手术患者,使用通用麻醉药和外周神经阻滞麻醉药联合麻醉。采用随机数字表法将患者分配到F-D组(芬太尼联合右美托咪定,n=34)或Es-D组(艾司卡胺联合右美托咪定,n=38)。主要结果指标包括首次使用解救性镇痛药的时间、解救性镇痛药的剂量和术后睡眠质量:结果:两组患者的基线特征无差异。结果:两组患者的基线特征无差异,Es-D 组患者术后使用镇痛药的时间明显更短(P<0.05):与芬太尼相比,Esketamine 的镇痛效果更好,术后副作用更小。但睡眠质量没有改善:关节置换术 术后镇痛药 Esketamine 睡眠质量 患者自控镇痛药
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引用次数: 0
Risk Factors for Cytomegalovirus Infection after Haematopoietic Stem Cell Transplantation: A Meta-Analysis. 造血干细胞移植后巨细胞病毒感染的风险因素:一项 Meta 分析。
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1605
Si-Ting Wu, Chun-Li Wang, Li Wang, Cai-Yun Zhang

Cytomegalovirus (CMV) infection is the most common viral infection after haematopoietic stem cell transplantation (HSCT). However, studies on related risk factors give different views without any clear conclusion. Therefore, the purpose of this study was to evaluate the risk variables of CMV infection after HSCT in order to provide recommendations for therapeutic treatment. The National Knowledge Infrastructure [CNKI], Chinese Biomedical Literature database [SinoMed], Wanfang Digital Periodicals [WANFANG] and China Science and Technology Journal [VIP] databases, as well as PubMed, Embase, CENTRAL, Web of Science databases were searched. The search keyword was Cumulative Index of Nursing and Related Health Literature (CINAHL). The search time spanned from the time when the database was created to February 2023. Based on inclusion and exclusion criteria, two researchers independently chose the literature, retrieved data, and assessed the bias risk. The methodological quality of the included studies was assessed by the Newcastle Ottawa scale (NOS). A total of 1,038 literatures were retrieved, of which, 18 studies were finally included. The final results of meta-analysis showed that there were seven risk factors as follows: Acute graft-versus-host disease (aGVHD) grades II-IV (II-IV) [odds ratio = 3.39, 95% CI (2.13, 5.41), p <0.05]; ant-thymocyte globulin (ATG) administration in treatment [odds ratio = 2.53, 95% CI (1.41, 4.53), p <0.05]; cyclosporine level after transplantation (>300 ng/ml) [OR = 3.79, 95% CI (1.24, 11.65), p <0.05]; age [odds ratio = 1.83, 95% CI (1.06, 3.15), p <0.05]; neutrophil deficiency time [odds ratio = 6.58, 95% CI (2.24, 19.30), p <0.05]; CMV infection in recipients before transplantation [odds ratio = 6.32,95% CI (4.03, 9.90), p <0.05]; fungal infection [odds ratio = 2.63, 95% CI (1.09, 6.34), p <0.05]. This study preliminarily revealed that CMV infection after HSCT is related to aGVHD (II-IV), ATG administration in pretreatment, cyclosporine level (>300 ng/ml) after transplantation, age, neutrophil deficiency time, CMV infection in recipients before transplantation and fungal infection. However, the mechanisms behind the risk variables are unclear. Further research is necessary to understand the risk factors and to enhance the care of patients with these risk factors to prevent or control infection. Key Words: Haematopoietic stem cell transplantation, Cytomegalovirus infection, Risk factors, Meta-analysis.

巨细胞病毒(CMV)感染是造血干细胞移植(HSCT)后最常见的病毒感染。然而,关于相关风险因素的研究观点不一,没有明确的结论。因此,本研究旨在评估造血干细胞移植后CMV感染的风险变量,以便为治疗提供建议。本研究检索了国家知识基础设施[CNKI]、中国生物医学文献数据库[SinoMed]、万方数字期刊[WANFANG]和中国科技期刊[VIP]数据库,以及PubMed、Embase、CENTRAL和Web of Science数据库。检索关键词为《护理及相关健康文献累积索引》(CINAHL)。检索时间跨度为数据库创建时至 2023 年 2 月。根据纳入和排除标准,由两名研究人员独立选择文献、检索数据并评估偏倚风险。纳入研究的方法学质量采用纽卡斯尔-渥太华量表(NOS)进行评估。共检索到 1,038 篇文献,最终纳入了其中的 18 项研究。荟萃分析的最终结果显示,存在以下七个风险因素:移植后急性移植物抗宿主病(aGVHD)II-IV 级(II-IV)[几率比=3.39,95% CI(2.13,5.41),p 300 ng/ml][OR=3.79,95% CI(1.24,11.65),p 300 ng/ml]、年龄、中性粒细胞缺乏时间、移植前受者感染 CMV 和真菌感染。然而,这些风险变量背后的机制尚不清楚。有必要开展进一步研究,以了解风险因素,并加强对存在这些风险因素的患者的护理,预防或控制感染。关键词:造血干细胞造血干细胞移植 巨细胞病毒感染 风险因素 Meta分析
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引用次数: 0
Correlation of Air-Bone Gap on Pure Tone Audiometry with the Size of Perforation Assessed on Oto-Endoscopy. 纯音听力计显示的气骨间隙与耳内镜评估的穿孔大小的相关性
Pub Date : 2024-11-01 DOI: 10.29271/jcpsp.2024.11.1580
Aiman Fatima Naqvi, Syeda Uzma Naqvi, Nida Khan, Murtaza Ahsan Ansari, Iqbal A Muhammad Khyani

Objective: To determine the correlation between the air-bone gap on pure tone audiometry with size of perforation oto-endoscopically.  Study Design: A descriptive study. Place and Duration of the Study: Department of ENT - Head and Neck Surgery, Dow University of Health Sciences (DUHS), from February 2020 to August 2021.  Methodology: A total of 43 patients with dry central pars tensa tympanic membrane perforation were diagnosed through oto-endoscopy during the study. The mean air-bone gap was calculated by assessing each air-bone gap through pure tone audiometry at different frequencies i.e., 250 Hz, 500 Hz, 1,000 Hz, 2,000 Hz, and 4,000 Hz. Air-bone gap was found to be the average value of these frequencies. The photograph of the tympanic membrane was taken oto-endoscopically, and the ratio between size of the perforation to the entire area of the tympanic membrane was measured.

Results: During the course of the study, a total of 43 patients agreed to provide consent for this study. Out of the 43 patients, 16 (37.2%) were males and 27 (62.8%) were females. The age range was from 18 to 50 years with average age of 38.302 ± 5.74 years. The mean perforation size was 28.255 ± 9.16% while the mean air-bone gap was 28.000 ± 3.89 dB. It was concluded that the Pearson's correlation coefficient is directly correlated to perforation size and air-bone gap (r = 0.898, p <0.001). Further, hearing loss decreases with decreased middle ear volume and mastoid pneumatisation. Moreover, no change was seen in the mean air-bone gap according to the location of perforation.

Conclusion: The hearing loss due to perforation of the tympanic membrane was correlated to the size of the perforation. Further, hearing loss decreases with reduced middle ear volume and mastoid pneumatisation.

Key words: Size of perforation, Hearing loss, Air-bone gap, Oto-endoscopy, Conductive deafness, Mastoid pneumatisation.

目的确定纯音测听的气骨间隙与经鼻内镜穿孔大小之间的相关性。 研究设计:描述性研究。研究地点和时间:道尔健康科学大学(DUHS)耳鼻咽喉头颈外科,2020 年 2 月至 2021 年 8 月。 研究方法:研究期间,通过耳内镜检查共确诊了43名干性中央型鼓膜旁穿孔患者。通过不同频率(250 Hz、500 Hz、1,000 Hz、2,000 Hz 和 4,000 Hz)的纯音测听评估每个气骨间隙,计算平均气骨间隙。气骨间隙是这些频率的平均值。通过耳内镜拍摄鼓膜照片,测量穿孔大小与鼓膜整个面积的比率:在研究过程中,共有 43 名患者同意参与本研究。在 43 名患者中,男性 16 人(占 37.2%),女性 27 人(占 62.8%)。年龄在 18 至 50 岁之间,平均年龄为(38.302 ± 5.74)岁。平均穿孔大小为 28.255 ± 9.16%,平均气骨间隙为 28.000 ± 3.89 dB。结论是,皮尔逊相关系数与穿孔大小和气骨间隙直接相关(r = 0.898,p 结论:鼓膜穿孔导致的听力损失与穿孔的大小有关。此外,听力损失会随着中耳容积减小和乳突气化而减少:穿孔大小 听力损失 气骨间隙 耳内镜检查 传导性耳聋 乳突气化
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引用次数: 0
期刊
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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