Risk Factors for Renal Involvement in Childhood Henoch-Schonlein Purpura (IgA Vasculitis).

Shuhui Min, Xi Chen, Danfeng Wang, Xiao Lin, Guan Jiang
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Abstract

This study was designed to investigate the risk factors for renal involvement in children with immunoglobulin A (IgA) vasculitis. It is a hospital-based retrospective cohort study with a sample size of 117 children aged ≤16 years with primary IgA vasculitis. Out of 117 patients, 49 (41.9%) developed renal injury. Univariate analysis revealed that age, gastrointestinal bleeding (GIB), time of duration, white blood cell count, D-dimer, and platelet count were all associated with renal injury in the patients with HSP. These variables were included in the multivariate logistic regression analysis. Results showed that elevated D-dimer level, older age, and GIB were independent risk factors for renal damage in patients with IgA vasculitis. Key Words: Henoch-schonlein purpura, Immunoglobulin A vasculitis, Nephritis, D-dimer, Risk factors.

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儿童白癜风(IgA 血管炎)肾脏受累的风险因素。
本研究旨在调查免疫球蛋白A(IgA)血管炎患儿肾脏受累的风险因素。这是一项基于医院的回顾性队列研究,样本量为117名年龄≤16岁的原发性IgA血管炎患儿。在117名患者中,49人(41.9%)出现了肾损伤。单变量分析显示,年龄、消化道出血(GIB)、病程时间、白细胞计数、D-二聚体和血小板计数均与HSP患者的肾损伤有关。这些变量被纳入多变量逻辑回归分析。结果显示,D-二聚体水平升高、年龄较大和GIB是IgA血管炎患者肾损伤的独立危险因素。关键字过敏性紫癜 免疫球蛋白A血管炎 肾炎 D二聚体 危险因素
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