Analysis of the Ultrasensitive C-Reactive Protein and Homocysteine Biomarkers after Photobiomodulation Therapy in Hormone Blocker-Treated Mastectomized Women: A Randomized, Blind, and Controlled Clinical Study.

Juliano Abreu Pacheco, Kelly Fernanda Molena, Eugenia Velludo Veiga
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Abstract

Main: The pharmacological treatment of cancer can lead to undesirable hemodynamic adverse effects. Laser therapy may promote hemodynamic balance in these patients. This study aimed to analyze the values of the biomarkers ultrasensitive C-reactive protein (PCR_us) and Homocysteine (HCy) after the use of intravascular laser irradiation of blood (ILIB) in mastectomized patients using hormonal blockers Tamoxifen and Aromatase Inhibitors. Methods: This was an experimental, placebo-controlled, randomized clinical trial with experimental (G1) and control (G2) groups. In G1, patients were irradiated with ILIB using a red laser at 660 nm on the carotid artery, while G2 received a placebo treatment. Blood collection for HCy and us-CRP biomarker evaluation was conducted monthly for 4 months. Statistical analysis was performed using R Studio 4.4.2 and JAMOVI, with a significance level of 5%. Results: A total of 21 patients participated in the study, with 12 in G1 and 9 in G2. There were no differences in age, systolic, diastolic blood pressure, and heart rate between the groups. The initial and final mean PCR_us levels for G1 were 6.8 and 3.8 mg/dL, and for HCy were 14.2 and 12.1 µmol/L, respectively. While for G2 initial and final mean PCR_us levels were 9.40 and 7.60 mg/dL, and for HCy were 14.33 and 16.69 µmol/L. There was no statistical difference for PCR_us. However, a significant difference between the groups (p < 0.05) for HCy in the 3rd and 4th months. Conclusion: During ILIB Therapy, there was a reduction in HCy, which may favor the improvement of cardiovascular function in these patients undergoing anticancer therapies.

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激素阻断剂治疗的乳房切除妇女接受光生物调节疗法后的超敏 C 反应蛋白和同型半胱氨酸生物标志物分析:一项随机、盲法对照临床研究。
主要内容:癌症的药物治疗可能会对血液动力学产生不良影响。激光疗法可促进这些患者的血液动力学平衡。本研究旨在分析使用激素阻断剂他莫昔芬和芳香化酶抑制剂的乳腺切除术患者使用血管内激光照射血液(ILIB)后的生物标志物超敏 C 反应蛋白(PCR_us)和同型半胱氨酸(HCy)的值。研究方法这是一项实验、安慰剂对照、随机临床试验,分为实验组(G1)和对照组(G2)。在 G1 组中,使用波长为 660 纳米的红色激光对患者的颈动脉进行 ILIB 照射,而 G2 组则接受安慰剂治疗。在为期 4 个月的时间里,每月采集血液进行 HCy 和 us-CRP 生物标志物评估。统计分析使用 R Studio 4.4.2 和 JAMOVI 进行,显著性水平为 5%。结果共有 21 名患者参与了研究,其中 G1 组 12 人,G2 组 9 人。两组患者的年龄、收缩压、舒张压和心率均无差异。G1 组的 PCR_us 初始和最终平均水平分别为 6.8 和 3.8 mg/dL,HCy 初始和最终平均水平分别为 14.2 和 12.1 µmol/L。而 G2 的 PCR_us 初始和最终平均水平分别为 9.40 和 7.60 mg/dL,HCy 为 14.33 和 16.69 µmol/L。PCR_us 没有统计学差异。但在第 3 个月和第 4 个月,各组间的 HCy 存在明显差异(p < 0.05)。结论在 ILIB 治疗期间,HCy 有所下降,这可能有利于正在接受抗癌治疗的患者改善心血管功能。
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4.10
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期刊介绍: Photobiomodulation, Photomedicine, and Laser Surgery Editor-in-Chief: Michael R Hamblin, PhD Co-Editor-in-Chief: Heidi Abrahamse, PhD
期刊最新文献
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