{"title":"5-Formylcytosine: a new epigenetic player","authors":"Dharmendra Kumar, Iqbal Hyder, Wilfried A. Kues","doi":"10.1038/s41392-024-02016-7","DOIUrl":null,"url":null,"abstract":"<p>In a landmark study published in <i>Cell</i>, Parasyraki et al. demonstrated a functional role of 5-formylcytosine (5fC) as an epigenetic mark during zygotic/embryonic genome activation (ZGA) in <i>Xenopus</i> and murine embryos that is spatially associated with RNA polymerase III (Pol III) transcription.<sup>1</sup> ZGA (or maternal to embryonic transition) is the unique phase of embryonic development when the maternal genome of the oocyte is reprogrammed to an embryonic gene expression.</p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":null,"pages":null},"PeriodicalIF":40.8000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-02016-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In a landmark study published in Cell, Parasyraki et al. demonstrated a functional role of 5-formylcytosine (5fC) as an epigenetic mark during zygotic/embryonic genome activation (ZGA) in Xenopus and murine embryos that is spatially associated with RNA polymerase III (Pol III) transcription.1 ZGA (or maternal to embryonic transition) is the unique phase of embryonic development when the maternal genome of the oocyte is reprogrammed to an embryonic gene expression.
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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