Birth of organocatalysis by N-heterocyclic carbenes

IF 42.8 1区化学 Q1 CHEMISTRY, PHYSICAL Nature Catalysis Pub Date : 2024-10-23 DOI:10.1038/s41929-024-01235-z

Sukriyo Chakraborty, Akkattu T. Biju

引用次数: 0

Abstract

Thiamine, a common enzymatic cofactor, catalyses the benzoin condensation. From 1943, a panoply of mechanistic proposals were invoked to explain the intriguing transformation until two seminal papers by Ronald Breslow about 15 years after the discovery of this reaction helped resolve the mechanistic conundrum and heralded the birth of NHC-organocatalysis.

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N-heterocyclic carbenes 有机催化的诞生

硫胺素是一种常见的酶辅助因子，可催化安息香缩合反应。从 1943 年开始，人们提出了各种各样的机理建议来解释这种有趣的转化，直到罗纳德-布雷斯洛（Ronald Breslow）在发现该反应约 15 年后发表了两篇开创性论文，才帮助解决了机理难题，并预示着 NHC 有机催化的诞生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

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