The Current State of the Art of Dearomatization Chemistry

IF 4.4 2区 化学 Q2 CHEMISTRY, APPLIED Advanced Synthesis & Catalysis Pub Date : 2024-10-25 DOI:10.1002/adsc.202401218
David Sarlah, Shu-Li You
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脱芳烃化学的技术现状
在小型有机分子中,芳香族化合物被认为是最丰富、用途最广的构件之一,目前每年的产量达一亿吨。此外,由于其固有的共振稳定性,近两个世纪以来,芳香族化合物一直吸引着科学家的目光,同时也为合成化学家带来了无尽的灵感。烯的化学性质自成一类,因为只有这类化合物才具有许多独特的反应活性。脱芳烃反应就是其中一种特征性转化--这种反应可以克服芳香稳定作用,将烯烃转化为饱和、非芳香化合物。从历史上看,这类转化仅限于脱芳烃氢化、溶解金属还原(桦木反应)和苯酚氧化;然而,在过去的几十年中,该领域的新型脱芳烃策略呈指数级增长,并取得了根本性进展。由于医药和天然产品化学迫切需要生产具有密集功能性、饱和度(sp3 含量)不断提高以及不同螺环和多环结构的分子,脱芳烃反应已成为合成化学和分子科学前沿领域提供多种解决方案的平台。结合催化、光化学、杂环化学、电化学和生物催化等领域的进步和最新反应范式,产生了大量脱芳烃方法,极大地扩展了从简单烷烃中获得构件的范围和复杂性。这些方法包括在脱芳烃过程中采用不对称催化策略的对映体选择性变体。我们感谢作者们的宝贵贡献,这些贡献展示了这些转化过程如何提供独特的分子断开和产物,提供了有机合成中最快速的复杂性生成策略之一,并将在未来的岁月中继续启发我们。
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来源期刊
Advanced Synthesis & Catalysis
Advanced Synthesis & Catalysis 化学-应用化学
CiteScore
9.40
自引率
7.40%
发文量
447
审稿时长
1.8 months
期刊介绍: Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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