Abnormal enterohepatic circulation of bile acids caused by fructooligosaccharide supplementation along with a high-fat diet.

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Food & Function Pub Date : 2024-10-25 DOI:10.1039/d4fo03353a
Fang Zeng, Shi He, Ying Sun, Xue Li, Kaiyang Chen, Hongbin Wang, Shuli Man, Fuping Lu
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Abstract

Fructooligosaccharide (FOS) is a widely used prebiotic and health food ingredient, but few reports have focused on its risk to specific populations. Recently, it has been shown that the intake of inulin, whose main component is FOS, can lead to cholestasis and induce hepatocellular carcinoma in mice fed a high-fat diet (HFD); however, the molecular mechanism behind this is not clear. This study found that FOS supplementation induced abnormal enterohepatic circulation of bile acids in HFD-fed mice, which showed a significant increase in bile acid levels in the blood and liver, especially the secondary bile acids with high cytotoxicity, such as deoxycholic acid. The abundance of Clostridium, Bacteroides, and other bacteria in the gut microbiota also increased significantly. The analysis of the signaling pathway involved in regulating the enterohepatic circulation of bile acids showed that the weakening of the feedback inhibition of FXR-FGF15 and FXR-SHP signalling pathways possibly induced the enhancement of CYP7A1 activity and bile acid reabsorption in the blood and liver and led to an increase in bile acid synthesis and accumulation in the liver, increasing the risk of cholestasis. This study showed the risk of health damage caused by FOS supplementation in HFD-fed mice, which is caused by gut microbiota dysfunction and abnormal enterohepatic circulation of bile acids. Therefore, the application of FOS should be standardized to avoid the health risks of unreasonable FOS use in specific populations.

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果寡糖补充剂和高脂肪饮食导致胆汁酸肠肝循环异常。
果寡糖(FOS)是一种广泛使用的益生元和保健食品成分,但很少有报道关注它对特定人群的风险。最近有研究表明,摄入菊粉(其主要成分是果寡糖)会导致高脂饮食(HFD)小鼠胆汁淤积并诱发肝细胞癌,但其背后的分子机制尚不清楚。这项研究发现,补充 FOS 会诱发高脂饮食小鼠胆汁酸肠肝循环异常,血液和肝脏中的胆汁酸含量显著增加,尤其是脱氧胆酸等具有高细胞毒性的次级胆汁酸。肠道微生物群中的梭状芽孢杆菌、乳酸杆菌和其他细菌的数量也显著增加。对参与调节胆汁酸肠肝循环的信号通路的分析表明,FXR-FGF15 和 FXR-SHP 信号通路的反馈抑制作用减弱,可能诱导 CYP7A1 活性增强,血液和肝脏对胆汁酸的重吸收增加,导致胆汁酸合成增加和在肝脏的蓄积,增加了胆汁淤积症的风险。该研究表明,在高密度脂蛋白饲料喂养的小鼠中补充 FOS 有可能造成健康损害,而健康损害是由肠道微生物群功能紊乱和胆汁酸肠肝循环异常引起的。因此,应规范 FOS 的应用,避免在特定人群中不合理使用 FOS 对健康造成危害。
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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
期刊最新文献
Human milk oligosaccharides and milk fat globule membrane reduce allergic reactions in mice through the modulation of gut microbiota and metabolic functions. Back cover Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides. Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1. Abnormal enterohepatic circulation of bile acids caused by fructooligosaccharide supplementation along with a high-fat diet.
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