Determinism of formamide-based biogenic prebiotic reactions

IF 13.7 1区 生物学 Q1 BIOLOGY Physics of Life Reviews Pub Date : 2024-10-16 DOI:10.1016/j.plrev.2024.10.004
Raffaele Saladino, Bruno Mattia Bizzarri, Ernesto Di Mauro
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Abstract

Formamide reacted in the presence of a catalyst and of a source of energy affords a rich and complex panel of compounds, including amino acids, amino sugars, nucleic bases, nucleosides, carboxylic acids, aliphatic chains, and more. Nor the source of energy nor the type of catalyst are fastidious. All the catalysts tested have activity; each catalyst affords its own specific set of products, although the panels of products of each catalyst largely overlap. Potentially biogenic compounds form in reasonable conditions and the chemistry that determines the initial syntheses is facile. Hence, Darwins warm little pond did not rely on exotic environments nor on magic tricks. The type of molecules resulting from a mixture of formamide and of two selected products of its initial reactions hint that the initial prebiotic soup was deterministic and oriented towards life-as-we-know-it.
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甲酰胺类生物源生物反应的决定性。
甲酰胺在催化剂和能量源的存在下发生反应,可产生丰富而复杂的化合物,包括氨基酸、氨基糖、核酸、核苷、羧酸、脂肪链等。对能量来源和催化剂类型的要求都不严格。所有测试过的催化剂都具有活性;每种催化剂都能提供自己特定的一组产物,尽管每种催化剂的产物板在很大程度上是重叠的。潜在的生物化合物在合理的条件下形成,决定初始合成的化学反应也很简单。因此,达尔文温暖的小池塘并不依赖于奇异的环境或魔术。甲酰胺和其初始反应的两种精选产物的混合物所产生的分子类型暗示,最初的前生物汤是确定性的,是面向我们所知的生命的。
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来源期刊
Physics of Life Reviews
Physics of Life Reviews 生物-生物物理
CiteScore
20.30
自引率
14.50%
发文量
52
审稿时长
8 days
期刊介绍: Physics of Life Reviews, published quarterly, is an international journal dedicated to review articles on the physics of living systems, complex phenomena in biological systems, and related fields including artificial life, robotics, mathematical bio-semiotics, and artificial intelligent systems. Serving as a unifying force across disciplines, the journal explores living systems comprehensively—from molecules to populations, genetics to mind, and artificial systems modeling these phenomena. Inviting reviews from actively engaged researchers, the journal seeks broad, critical, and accessible contributions that address recent progress and sometimes controversial accounts in the field.
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