Pub Date : 2026-01-29DOI: 10.1016/j.plrev.2026.01.009
Shimul Biswas, Krishna Kishore Mahato
Collagen remodeling in the extracellular matrix drives alterations in the physical, mechanical, and optical properties of tissues, representing a fundamental biophysical hallmark of colorectal cancer (CRC) progression. These changes, reflected in variations in collagen composition, molecular orientation, and cross-linking density, transform tissue stiffness, elasticity, and anisotropy, directly influencing cancer cell behavior and mechanotransduction. Understanding these structural and physical transitions requires analytical methods capable of probing the molecular origins of biomechanical alteration in situ. Spectroscopic and optical methodologies provide high-resolution, label-free detection of the vibrational, optical, and mechanical alteration associated with collagen remodeling. These techniques capture the shifts in molecular vibrational modes, nonlinear optical responses, and scattering anisotropy that arise from collagen fibril alignment, structural disorder, and cross-link formation, thereby connecting molecular architecture to measurable macroscale biomechanics. The integration of multimodal spectroscopy and incorporation of machine learning algorithms further enhance diagnostic performance by resolving complex tissue heterogeneity and improving tumor margin detection. Overall, this review demonstrates how spectroscopic techniques can be applied in the biomedical field for cancer detection by analyzing collagen remodeling and structural alterations.
{"title":"Biophysical approaches to cancer diagnostics: Collagen biomarkers in colorectal cancer.","authors":"Shimul Biswas, Krishna Kishore Mahato","doi":"10.1016/j.plrev.2026.01.009","DOIUrl":"https://doi.org/10.1016/j.plrev.2026.01.009","url":null,"abstract":"<p><p>Collagen remodeling in the extracellular matrix drives alterations in the physical, mechanical, and optical properties of tissues, representing a fundamental biophysical hallmark of colorectal cancer (CRC) progression. These changes, reflected in variations in collagen composition, molecular orientation, and cross-linking density, transform tissue stiffness, elasticity, and anisotropy, directly influencing cancer cell behavior and mechanotransduction. Understanding these structural and physical transitions requires analytical methods capable of probing the molecular origins of biomechanical alteration in situ. Spectroscopic and optical methodologies provide high-resolution, label-free detection of the vibrational, optical, and mechanical alteration associated with collagen remodeling. These techniques capture the shifts in molecular vibrational modes, nonlinear optical responses, and scattering anisotropy that arise from collagen fibril alignment, structural disorder, and cross-link formation, thereby connecting molecular architecture to measurable macroscale biomechanics. The integration of multimodal spectroscopy and incorporation of machine learning algorithms further enhance diagnostic performance by resolving complex tissue heterogeneity and improving tumor margin detection. Overall, this review demonstrates how spectroscopic techniques can be applied in the biomedical field for cancer detection by analyzing collagen remodeling and structural alterations.</p>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"239-257"},"PeriodicalIF":14.3,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.plrev.2026.01.007
Zhu-Qing Gong , Xi-Nian Zuo
In our target article “Dark Brain Energy: Toward an Integrative Model of Spontaneous Slow Oscillations”, we proposed a three-layer hierarchical framework to model the spontaneous slow oscillations (SSOs) across six frequency bands to delineate their spectral architecture, functional roles, and neurocognitive basis. We are grateful for the seven insightful commentary articles from colleagues across neuroscience, physics, mathematics, psychology and clinics, which collectively enrich our framework. In this review, we address five key themes emerging from and inspired by these commentaries: (1) the relationship between SSOs and consciousness, (2) the geometric foundations of SSOs, (3) evolutionary, developmental, and metabolic mechanisms of SSOs, (4) mathematical modeling of traveling waves underlying SSOs, and (5) neuroscientific implications for brain-inspired intelligence. We finally integrate these perspectives to refine our original model and outline future research directions.
{"title":"Illuminating brain’s “dark energy”: a living lens of spontaneous slow oscillations. reply to comments on ‘dark brain energy: toward an integrative model of spontaneous slow oscillations’","authors":"Zhu-Qing Gong , Xi-Nian Zuo","doi":"10.1016/j.plrev.2026.01.007","DOIUrl":"10.1016/j.plrev.2026.01.007","url":null,"abstract":"<div><div>In our target article “<em>Dark Brain Energy: Toward an Integrative Model of Spontaneous Slow Oscillations</em>”, we proposed a three-layer hierarchical framework to model the spontaneous slow oscillations (SSOs) across six frequency bands to delineate their spectral architecture, functional roles, and neurocognitive basis. We are grateful for the seven insightful commentary articles from colleagues across neuroscience, physics, mathematics, psychology and clinics, which collectively enrich our framework. In this review, we address five key themes emerging from and inspired by these commentaries: (1) the relationship between SSOs and consciousness, (2) the geometric foundations of SSOs, (3) evolutionary, developmental, and metabolic mechanisms of SSOs, (4) mathematical modeling of traveling waves underlying SSOs, and (5) neuroscientific implications for brain-inspired intelligence. We finally integrate these perspectives to refine our original model and outline future research directions.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 227-235"},"PeriodicalIF":14.3,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.plrev.2026.01.008
Nicco Reggente , Theo Tobel , Michael Lifshitz
{"title":"Mnemonics, optimization, and leveraging what we already have: Comment on “To enhance or not to enhance: A debate about cognitive enhancement from a psychological and neuroscientific perspective” by Grinschgl, S., Ninaus, M., Wood, G., & Neubauer, A. C","authors":"Nicco Reggente , Theo Tobel , Michael Lifshitz","doi":"10.1016/j.plrev.2026.01.008","DOIUrl":"10.1016/j.plrev.2026.01.008","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 236-238"},"PeriodicalIF":14.3,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sirtuins as modulators of infection outcomes in host-pathogen dynamics, comment on \"Sirtuins as modulators of infection outcomes in the battle of host-pathogen dynamics\"","authors":"Yongzheng Han , Zunwen Zheng , Xinxiu Ren , Guangzhen Wu","doi":"10.1016/j.plrev.2026.01.005","DOIUrl":"10.1016/j.plrev.2026.01.005","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 220-222"},"PeriodicalIF":14.3,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.plrev.2026.01.004
Feiyan Chen , Fan Liu , Jingcheng Wang , Rengqin Sun , Hongjian He , Xi-Nian Zuo
{"title":"General integration theory of cognitive emergent: Comment on \"Brain dynamics shape cognition–spatiotemporal neuroscience\" by Georg Northoff, Angelika Wolman and Jianfeng Zhang","authors":"Feiyan Chen , Fan Liu , Jingcheng Wang , Rengqin Sun , Hongjian He , Xi-Nian Zuo","doi":"10.1016/j.plrev.2026.01.004","DOIUrl":"10.1016/j.plrev.2026.01.004","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 223-226"},"PeriodicalIF":14.3,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-11DOI: 10.1016/j.plrev.2026.01.001
Xiuluan Du , Yuansheng Lin
{"title":"Protein post-translational modifications in tumor immunity: a multi-layered regulatory network deserving systematic decoding Comment on “Protein post-translational modifications and tumor immunity: A pan-cancer perspective”","authors":"Xiuluan Du , Yuansheng Lin","doi":"10.1016/j.plrev.2026.01.001","DOIUrl":"10.1016/j.plrev.2026.01.001","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 218-219"},"PeriodicalIF":14.3,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.plrev.2026.01.002
Yongzheng Han , Chengming Li , Yuanhua Qin , Guangzhen Wu
{"title":"Comment on \" Protein post-translational modifications and tumor immunity: A pan-cancer perspective\"","authors":"Yongzheng Han , Chengming Li , Yuanhua Qin , Guangzhen Wu","doi":"10.1016/j.plrev.2026.01.002","DOIUrl":"10.1016/j.plrev.2026.01.002","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 215-217"},"PeriodicalIF":14.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.plrev.2025.12.009
Matej Hoffmann, Zdenek Straka
{"title":"Toward embodied and action-oriented studies and models of peripersonal space: Comment on “Computational models of peripersonal space representations” by Bertoni et al.","authors":"Matej Hoffmann, Zdenek Straka","doi":"10.1016/j.plrev.2025.12.009","DOIUrl":"10.1016/j.plrev.2025.12.009","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 212-214"},"PeriodicalIF":14.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.plrev.2025.12.013
Andrew Yu Morozov
{"title":"On implementation of nonlocal terms in models in ecology and evolution. Comment on ‘Nonlocal models in biology and life sciences: Sources, developments, and applications’ by S. Pal & R. Melnick","authors":"Andrew Yu Morozov","doi":"10.1016/j.plrev.2025.12.013","DOIUrl":"10.1016/j.plrev.2025.12.013","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 208-211"},"PeriodicalIF":14.3,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.plrev.2025.12.014
Han Zhang , Jincan Che
{"title":"From Hierarchical Decoding to State Dependent Computation: “Comment on Neural decoding in brain computer interfaces Hierarchical representations, complexity measures, and dynamical perspectives” by Li et al.","authors":"Han Zhang , Jincan Che","doi":"10.1016/j.plrev.2025.12.014","DOIUrl":"10.1016/j.plrev.2025.12.014","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 202-203"},"PeriodicalIF":14.3,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号