Metallic nanoparticles: a promising novel therapeutic tool against antimicrobial resistance and spread of superbugs.

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-10-24 DOI:10.1007/s10534-024-00647-5
Naheem Adekilekun Tijani, Joseph Hokello, Emmanuel Eilu, Saheed Adekunle Akinola, Abdullateef Opeyemi Afolabi, Danladi Makeri, Tonny Wotoyitide Lukwago, Irene M Mutuku, Alex Mwesigwa, Andrew Baguma, Ismail Abiola Adebayo
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Abstract

In recent years, antimicrobial resistance (AMR) has become an alarming threat to global health as notable increase in morbidity and mortality has been ascribed to the emergence of superbugs. The increase in microbial resistance because of harboured or inherited resistomes has been complicated by the lack of new and effective antimicrobial agents, as well as misuse and failure of existing ones. These problems have generated severe and growing public health concern, due to high burden of bacterial infections resulting from scarce financial resources and poor functioning health systems, among others. It is therefore, highly pressing to search for novel and more efficacious alternatives for combating the action of these super bacteria and their infection. The application of metallic nanoparticles (MNPs) with their distinctive physical and chemical attributes appears as promising tools in fighting off these deadly superbugs. The simple, inexpensive and eco-friendly model for enhanced biologically inspired MNPs with exceptional antimicrobial effect and diverse mechanisms of action againsts multiple cell components seems to offer the most promising option and said to have enticed many researchers who now show tremendous interest. This synopsis offers critical discussion on application of MNPs as the foremost intervening strategy to curb the menace posed by the spread of superbugs. As such, this review explores how antimicrobial properties of the metallic nanoparticles which demonstrated considerable efficacy against several multi-drugs resistant bacteria, could be adopted as promising approach in subduing the threat of AMR and harvoc resulting from the spread of superbugs.

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金属纳米粒子:一种有前途的新型治疗工具,可对抗抗菌药耐药性和超级细菌的传播。
近年来,由于超级细菌的出现导致发病率和死亡率显著上升,抗菌药耐药性(AMR)已成为全球健康面临的一个令人担忧的威胁。由于缺乏新的有效抗菌剂,以及现有抗菌剂的滥用和失效,藏匿或遗传的抗菌基因组导致的微生物抗药性增加变得更加复杂。由于财政资源匮乏和卫生系统运作不善等原因造成的细菌感染负担沉重,这些问题引发了严重且日益严重的公共卫生问题。因此,寻找新型、更有效的替代品来对抗这些超级细菌的作用及其感染已迫在眉睫。金属纳米粒子(MNPs)具有独特的物理和化学属性,其应用似乎有望成为抵御这些致命超级细菌的工具。受生物启发的 MNPs 具有卓越的抗菌效果和针对多种细胞成分的不同作用机制,这种简单、廉价、环保的增强型 MNPs 模型似乎提供了最有前途的选择,据说吸引了许多研究人员,他们现在对此表现出了极大的兴趣。本综述对应用 MNPs 作为遏制超级细菌传播威胁的首要干预策略进行了深入探讨。因此,本综述探讨了金属纳米粒子的抗菌特性(该特性对多种耐药细菌具有显著疗效)可如何作为一种有前途的方法来抑制因超级细菌传播而导致的 AMR 和 Harvoc 威胁。
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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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