Effects of Ferulic Acid on Lipopolysaccharide-Induced Oxidative Stress and Gut Microbiota Imbalance in Linwu Ducks.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-09-30 DOI:10.3390/antiox13101190

Yang Liu, Xuan Huang, Chuang Li, Ping Deng, Xu Zhang, Yan Hu, Qiuzhong Dai

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Abstract

Oxidative stress is a major factor that limits the development of the poultry industry. Ferulic acid (FA) has an antioxidant effect in birds, but the mechanism is not fully understood. In this study, we stimulated oxidative stress in 28-day-old female Linwu ducks by lipopolysaccharide (LPS) and fed them a diet supplemented with FA for 28 days. Results showed that FA alleviated LPS-induced growth performance regression, oxidative stress, and microbiota imbalance in ducks. An integrated metagenomics and metabolomics analysis revealed that s_Blautia_obeum, s_Faecalibacterium_prausnitzii, s_gemmiger_formicilis, and s_Ruminococcaceae_bacterium could be the biomarkers in the antioxidant effect of FA, which interacted with dihydro-3-coumaric acid, L-phenylalanine, and 13(S)-HODE, and regulated the phenylalanine metabolism and PPAR signaling pathway. This study revealed the mechanism of the antioxidant effect of FA, which provided evidence of applying FA as a new antioxidant in commercial duck production.

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阿魏酸对脂多糖诱导的临武鸭氧化应激和肠道微生物群失衡的影响

氧化应激是限制家禽业发展的一个主要因素。阿魏酸（FA）对禽类有抗氧化作用，但其机制尚未完全清楚。在本研究中，我们用脂多糖（LPS）刺激 28 日龄雌性临武鸭的氧化应激，并用添加阿魏酸的日粮饲喂 28 天。结果表明，脂肪酸能缓解 LPS 引起的鸭生长性能下降、氧化应激和微生物群失衡。综合元基因组学和代谢组学分析发现，s_Blautia_obeum、s_Faecalibacterium_prausnitzii、s_gemmiger_formicilis和s_Ruminococcaceae_bacterium可能是FA抗氧化作用的生物标志物，它们与二氢-3-香豆酸、L-苯丙氨酸和13(S)-HODE相互作用，调控苯丙氨酸代谢和PPAR信号通路。该研究揭示了 FA 的抗氧化作用机制，为 FA 作为一种新型抗氧化剂应用于商品鸭生产提供了证据。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.