Innovations in Nuclear Medicine Imaging for Reactive Oxygen Species: Applications and Radiopharmaceuticals.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-10-17 DOI:10.3390/antiox13101254

Joo Yeon Park, Sun Mi Park, Tae Sup Lee, Sang Ju Lee, Ji-Young Kim, Seung Jun Oh, Hai-Jeon Yoon, Bom Sahn Kim, Byung Seok Moon

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Abstract

Reactive oxygen species (ROS) are generated during normal cellular energy production and play a critical role in maintaining cellular function. However, excessive ROS can damage cells and tissues, contributing to the development of diseases such as cardiovascular, inflammatory, and neurodegenerative disorders. This review explores the potential of nuclear medicine imaging techniques for detecting ROS and evaluates various radiopharmaceuticals used in these applications. Radiopharmaceuticals, which are drugs labeled with radionuclides, can bind to specific biomarkers, facilitating their identification in vivo using nuclear medicine equipment, i.e., positron emission tomography and single photon emission computed tomography, for diagnostic purposes. This review includes a comprehensive search of PubMed, covering radiopharmaceuticals such as analogs of fluorescent probes and antioxidant vitamin C, and biomarkers targeting mitochondrial complex I or cystine/glutamate transporter.

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活性氧核医学成像的创新：应用与放射性药物。

活性氧（ROS）是在正常的细胞能量生成过程中产生的，在维持细胞功能方面起着至关重要的作用。然而，过量的 ROS 会损伤细胞和组织，导致心血管、炎症和神经退行性疾病等疾病的发生。这篇综述探讨了核医学成像技术在检测 ROS 方面的潜力，并对这些应用中使用的各种放射性药物进行了评估。放射性药物是用放射性核素标记的药物，可与特定的生物标记物结合，便于使用核医学设备（即正电子发射断层扫描和单光子发射计算机断层扫描）在体内对其进行识别，从而达到诊断目的。这篇综述对 PubMed 进行了全面搜索，内容包括荧光探针和抗氧化维生素 C 类似物等放射性药物，以及针对线粒体复合体 I 或胱氨酸/谷氨酸转运体的生物标记物。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.