Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-10-18 DOI:10.3390/antiox13101270
Giovanni Tossetta, Sonia Fantone, Lucrezia Togni, Andrea Santarelli, Fabiola Olivieri, Daniela Marzioni, Maria Rita Rippo
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Abstract

Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption. The nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays a key role in periodontitis by modulating redox balance and inflammation of the periodontium. However, NRF2 expression is decreased in gingival tissues of patients with periodontitis while oxidative stress is significantly increased in this pathology. Oxidative stress and lipopolysaccharide (LPS) produced by gram-negative bacteria favor the production of inflammatory causing periodontal inflammation and favoring alveolar bone. In this review, we analyzed the current literature regarding the role of natural and synthetic compounds in modulating the NRF2/KEAP1 pathway in in vitro and in vivo models of periodontitis in order to evaluate new potential treatments of periodontitis that can improve the outcome of this disease.

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植物疗法在牙周炎中对 NRF2/KEAP1 信号的调节作用
牙周炎影响着多达 40% 的 60 岁以上成年人,是牙龈炎的后遗症。牙周炎的特点是慢性炎症、牙周损伤和牙槽骨吸收。核因子红细胞 2 相关因子 2(NFE2L2 或 NRF2)/Kelch 样 ECH 相关蛋白 1(KEAP1)(NRF2/KEAP1)信号通路通过调节氧化还原平衡和牙周炎症在牙周炎中起着关键作用。然而,在牙周炎患者的牙龈组织中,NRF2 的表达量减少,而氧化应激在这种病变中却显著增加。氧化应激和革兰氏阴性细菌产生的脂多糖(LPS)有利于炎症的产生,从而引起牙周炎症并有利于牙槽骨。在这篇综述中,我们分析了有关天然和合成化合物在牙周炎体外和体内模型中调节 NRF2/KEAP1 通路的作用的现有文献,以评估可改善牙周炎治疗效果的潜在新疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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