Quercetin and Thyroid.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-10-04 DOI:10.3390/antiox13101202
Cesidio Giuliani, Giulia Di Dalmazi, Ines Bucci, Giorgio Napolitano
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Abstract

Quercetin is the most abundant flavonoid present in fruits and vegetables. For its antiproliferative, antiviral, anti-inflammatory and antioxidants activities, it is an active ingredient of several herbal remedies and is available as a nutraceutical. Experimental studies performed in vitro have demonstrated that quercetin inhibits growth and function in normal thyroid cells and may act as a thyroid disruptor. These effects have also been confirmed in vivo using rodent models. Some studies have reported the ability of quercetin to interfere with the metabolism of thyroid hormones, since it inhibits the 5'-deiodinase type 1 (D1) activity in the thyroid, as well as in the liver. Besides the effects on normal thyroid cells, several experiments performed in vitro have shown a potential therapeutic role of quercetin in thyroid cancer. Indeed, quercetin inhibits the growth, the adhesion and the migration of thyroid cancer cells, and it also has redifferentiation properties in some thyroid cancer cell lines. In conclusion, these data suggest that, although its effects can be of benefit in hyperthyroidism and thyroid cancer, caution is required in the use of high doses of quercetin due to its anti-thyroid properties. Further in vivo studies are certainly needed to confirm these hypotheses.

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槲皮素与甲状腺
槲皮素是水果和蔬菜中含量最高的类黄酮。槲皮素具有抗增殖、抗病毒、抗炎和抗氧化作用,是多种草药的有效成分,也可作为营养保健品出售。体外实验研究表明,槲皮素会抑制正常甲状腺细胞的生长和功能,并可能成为甲状腺干扰素。利用啮齿动物模型进行的体内实验也证实了这些作用。一些研究报告称,槲皮素能够干扰甲状腺激素的新陈代谢,因为它能抑制甲状腺和肝脏中5'-脱碘酶1型(D1)的活性。除了对正常甲状腺细胞的影响外,一些体外实验还显示了槲皮素对甲状腺癌的潜在治疗作用。事实上,槲皮素能抑制甲状腺癌细胞的生长、粘附和迁移,还能使一些甲状腺癌细胞株发生再分化。总之,这些数据表明,尽管槲皮素对甲状腺机能亢进症和甲状腺癌有一定疗效,但由于其抗甲状腺特性,在使用大剂量槲皮素时仍需谨慎。当然,还需要进一步的体内研究来证实这些假设。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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