Effect of antenatal use of high energy nutritional supplements on cardio metabolic risk markers in underweight primi gravidas; a randomized controlled trial.

IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY BMC Pregnancy and Childbirth Pub Date : 2024-10-23 DOI:10.1186/s12884-024-06868-3
Kalsoom Tariq, Hafsa Zafar, Nabila Sher, Bela Inayat, Mashal Zafar, Fozia Fozia, Sofia Islam, Sadia Fatima, Ijaz Ahmad, Mohamed Mohany, Salim S Al-Rejaie, Mingkun Zhu
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Abstract

Backgroud: Pregnancy is a state of increased metabolic demand, and poor maternal nutrition can exacerbate these changes, potentially increasing the risk of cardiometabolic disorders.This study is significant as it investigates the effect of high energy nutritional supplements on cardio metabolic risk markers in underweight primigravidas.

Methodology: A single blinded randomized controlled trial was conducted from April 2018- August 2019 among the Pakistani tertiary care facilities of Khyber Pakhtunkhwa. A total of thirty six participants were randomized into two groups receiving either high energy nutritional supplement 'MAAMTA' or Placebo. They were instructed to take Placebo/Supplement alongside to their regular prenatal care and food from their first antenatal visit till a week postnatally. Anthropometric measurements and blood samples for biochemical parameters insulinlevels, fasting blood glucose & lipid profile were taken at baseline visit, between 16 and 20 weeks gestation and a post natal visit.

Results: The two-way repeated measures ANOVA showed that there was a highly significant time effect on participant's Insulin level (F (1.8, 53.6) = 10.64, P < 0 0.000, ηp2 = 0.269). A highly significant time effect on participant's insulin resistance (F (2, 68) = 8.116,P < 0 0.001, ηp2 = 0.193) was also observed. There was a highly significant time effect on participant's LDL level as well (F (2, 68) = 11.82, P < 0 0.000, ηp2 = 0.258).

Conclusion: Supplementation with high energy nutritional supplements may improve insulin levels and insulin sensitivity in underweight primigravidas.

Trial registration: https://www.

Clinicaltrials: gov ClinicalTrials.gov Identifier: ISRCTN 10088578. Registered on 27 March 2018. https://www.isrctn.com/ISRCTN10088578 .

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产前服用高能量营养补充剂对体重不足的初产妇心血管代谢风险指标的影响;随机对照试验。
背景:妊娠是一种代谢需求增加的状态,孕产妇营养不良会加剧这些变化,从而可能增加心脏代谢紊乱的风险。本研究调查了高能量营养补充剂对体重不足的初产妇心脏代谢风险指标的影响,因此具有重要意义:2018年4月至2019年8月,在巴基斯坦开伯尔巴图克瓦省的三级医疗机构中开展了一项单盲随机对照试验。共有36名参与者被随机分为两组,分别接受高能营养补充剂 "MAAMTA "或安慰剂。从第一次产前检查开始到产后一周,她们在接受常规产前护理和食物的同时,还要服用安慰剂/补充剂。在妊娠 16 至 20 周的基线访视和产后访视中,对孕妇进行了人体测量,并采集了血液样本,以检测生化指标胰岛素水平、空腹血糖和血脂情况:双向重复测量方差分析显示,时间对参与者的胰岛素水平有非常显著的影响(F (1.8, 53.6) = 10.64, P 2 = 0.269)。参与者的胰岛素抵抗也受到了高度显著的时间影响(F (2, 68) = 8.116,P 2 = 0.193)。参与者的低密度脂蛋白水平也有非常明显的时间效应(F (2, 68) = 11.82,P 2 = 0.258):补充高能量营养补充剂可改善体重不足的初产妇的胰岛素水平和胰岛素敏感性。试验注册:https://www.Clinicaltrials: gov ClinicalTrials.gov Identifier:ISRCTN 10088578。注册日期:2018 年 3 月 27 日。https://www.isrctn.com/ISRCTN10088578 。
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来源期刊
BMC Pregnancy and Childbirth
BMC Pregnancy and Childbirth OBSTETRICS & GYNECOLOGY-
CiteScore
4.90
自引率
6.50%
发文量
845
审稿时长
3-8 weeks
期刊介绍: BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.
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