Role of ethnicity and residency in active tuberculosis in Karakalpakstan: study protocol of a matched case-control study.

IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM BMJ Open Respiratory Research Pub Date : 2024-10-26 DOI:10.1136/bmjresp-2024-002554
Damin A Asadov, Timur Aripov, Sevak Alaverdyan, Diloram Sadikkhodjayeva, Gulmirza Yuldashev, Nargiza Allakova, Atadjan K Khamraev
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Abstract

Introduction: Uzbekistan is one of the 30 countries with the highest tuberculosis (TB) morbidity, accounting for 87% of all cases globally. The incidence of TB in the Republic of Karakalpakstan (RK) remains consistently high in comparison with other regions of Uzbekistan. The incidence rates of TB strongly differ even among the regions within RK. In 2019, the highest rates were registered in the northern and north-western regions, and the lowest in the southern regions. An important issue is the extent to which specific residencies impact individual health. The ethnic composition of the population of RK can be one of the possible causes for such geographical heterogeneity in TB morbidity.

Methods and analysis: The case-control design of this study primarily aims to evaluate the role of ethnicity and residency on the development of active TB in the community living in RK. Additionally, the study aims to measure the association between factors of TB morbidity and ethnicity/residency in the community of RK. It was decided to include one matched control for every included case, to control potential confounders. Cases with clinically diagnosed or bacteriologically confirmed TB will be randomly sampled from the patient registry. Controls will comprise individuals without TB, living in RK at the same time as the cases. They will be randomly sampled from a general roster of the residents.

Ethics and dissemination: This study was approved by the Bioethics Committee of the Medical Association of Uzbekistan (approval report of meeting #1 on 18 January 2024). The results of this study will be widely disseminated at scientific meetings and conferences, and published in a peer-reviewed journal.

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种族和居住地在卡拉卡尔帕克斯坦活动性结核病中的作用:配对病例对照研究的研究方案。
导言:乌兹别克斯坦是全球肺结核发病率最高的 30 个国家之一,占全球病例总数的 87%。与乌兹别克斯坦其他地区相比,卡拉卡尔帕克斯坦共和国(RK)的结核病发病率一直居高不下。即使在卡拉卡尔帕克斯坦共和国内的不同地区,结核病的发病率也存在很大差异。2019 年,北部和西北部地区的发病率最高,南部地区最低。一个重要的问题是特定居住地对个人健康的影响程度。兰卡地区人口的种族构成可能是造成结核病发病率地域异质性的原因之一:本研究采用病例对照设计,主要目的是评估种族和居住地对兰卡威社区居民活动性肺结核发病率的影响。此外,该研究还旨在衡量兰卡威社区结核病发病率因素与种族/居住地之间的关联。为控制潜在的混杂因素,研究决定每纳入一个病例,就纳入一个匹配的对照。经临床诊断或细菌学确诊的肺结核病例将从患者登记册中随机抽样。对照组由与病例同时居住在兰卡威的无肺结核患者组成。他们将从居民总名册中随机抽样:本研究已获得乌兹别克斯坦医学会生物伦理委员会的批准(2024 年 1 月 18 日第 1 次会议批准报告)。研究结果将在科学会议和大会上广泛传播,并在同行评审期刊上发表。
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来源期刊
BMJ Open Respiratory Research
BMJ Open Respiratory Research RESPIRATORY SYSTEM-
CiteScore
6.60
自引率
2.40%
发文量
95
审稿时长
12 weeks
期刊介绍: BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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