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Understanding beliefs about elexacaftor-tezacaftor-ivacaftor therapy in adults living with cystic fibrosis.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-31 DOI: 10.1136/bmjresp-2024-002546
Catherine O'Leary, Alec Vinh, Mari Lea-Davies, John Weinman, Rob Horne, Jamie Duckers

Background: A person's beliefs about treatment influence their engagement and adherence to that treatment. The Necessity-Concerns Framework suggests that adherence is influenced by a person's judgement of their own need for treatment (necessity beliefs) and concerns about the potential adverse consequences of taking the treatment. This study was conducted to explore the Necessity-Concerns Framework for elexacaftor-tezacaftor-ivacaftor (ETI) therapy (Kaftrio) in adults with cystic fibrosis (CF).

Methods: A total of 64 adults with CF were maintained on ETI therapy as part of their routine CF care, and completed the Beliefs about Medicines Questionnaire. Patient demographics, lung function, body mass index and quality of life using the Cystic Fibrosis Questionnaire Revised were collected as part of routine clinical care. Duration of ETI therapy along with medicines possession ratio was recorded.

Results: Patients reported strong beliefs about the necessity of ETI therapy. The majority of patients (78%) reported low concerns about ETI therapy while 22% of patients reported high concerns. A small number of patients (n=4) had concerns which were stronger than their beliefs about necessity.

Discussion: Patients reported strong beliefs in the necessity of ETI therapy. Although concerns were lower, a significant proportion of the sample had strong concerns about their ETI therapy. By being aware of people with CF's necessity and concerns beliefs around ETI therapy clinical teams will be better armed to engage them in treatment decisions and support optimal adherence.

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引用次数: 0
Changes in respiratory viruses in infancy during the SARS-CoV-2 pandemic: a prospective cohort study.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-26 DOI: 10.1136/bmjresp-2024-003044
Ruth Steinberg, Simone Troxler, Léa Ho Dac, Anne-Christianne Kentgens, Xenia Bovermann, Christoph Aebi, Urs Frey, Pascal Bittel, Philipp Agyeman, Philipp Latzin, Insa Korten

Background: Respiratory virus infections are a major cause of morbidity in early life. During the SARS-CoV-2 pandemic, non-pharmaceutical interventions (NPIs) lead to worldwide changes in respiratory virus epidemiology. However, evidence regarding virus circulation in the outpatient setting remains largely unknown. The aim of this study is to longitudinally assess respiratory viruses in healthy infants before and during the SARS-CoV-2 pandemic in Switzerland.

Methods: In this prospective observational birth cohort study, we followed 34 infants throughout the first year of life before and during the SARS-CoV-2 pandemic. We analysed 648 biweekly nasal swabs for nine different respiratory viruses by Multiplex-PCR and assessed respiratory symptoms, COVID-19 infections of family members and childcare status in weekly interviews. 712 nasal swabs from 32 infants analysed before the pandemic and published previously served as control group.

Results: During the period with strict NPIs (pandemic I), most common respiratory viruses were not detected, with a rebound (driven by Adenovirus and Parainfluenza virus) after most NPIs were relaxed (pandemic II): prepandemic: 27%, pandemic I: 19%, pandemic II: 33%; historic: 36% of collected swabs per period, p<0.001. Human rhinovirus (HRV) prevalence persisted during NPIs presence, mainly in the form of asymptomatic HRV detection: prepandemic=24%, pandemic I=19%, pandemic II=25%, historic: 25%, p=0.3. SARS-CoV-2 detection (asymptomatic and symptomatic) was low, and only present after NPIs were relaxed: pandemic II=2.4%. No severe COVID-19 infections were reported.

Discussion: In our cohort, infants did not contribute largely to spread of SARS-CoV-2. The role of persisting asymptomatic HRV prevalence is still unclear, but it might help to maintain population immunity to prevent more severe infections. Our results underscore the importance of capturing asymptomatic viruses via longitudinal community-based data assessment to better understand virus transmission.

{"title":"Changes in respiratory viruses in infancy during the SARS-CoV-2 pandemic: a prospective cohort study.","authors":"Ruth Steinberg, Simone Troxler, Léa Ho Dac, Anne-Christianne Kentgens, Xenia Bovermann, Christoph Aebi, Urs Frey, Pascal Bittel, Philipp Agyeman, Philipp Latzin, Insa Korten","doi":"10.1136/bmjresp-2024-003044","DOIUrl":"10.1136/bmjresp-2024-003044","url":null,"abstract":"<p><strong>Background: </strong>Respiratory virus infections are a major cause of morbidity in early life. During the SARS-CoV-2 pandemic, non-pharmaceutical interventions (NPIs) lead to worldwide changes in respiratory virus epidemiology. However, evidence regarding virus circulation in the outpatient setting remains largely unknown. The aim of this study is to longitudinally assess respiratory viruses in healthy infants before and during the SARS-CoV-2 pandemic in Switzerland.</p><p><strong>Methods: </strong>In this prospective observational birth cohort study, we followed 34 infants throughout the first year of life before and during the SARS-CoV-2 pandemic. We analysed 648 biweekly nasal swabs for nine different respiratory viruses by Multiplex-PCR and assessed respiratory symptoms, COVID-19 infections of family members and childcare status in weekly interviews. 712 nasal swabs from 32 infants analysed before the pandemic and published previously served as control group.</p><p><strong>Results: </strong>During the period with strict NPIs (pandemic I), most common respiratory viruses were not detected, with a rebound (driven by Adenovirus and Parainfluenza virus) after most NPIs were relaxed (pandemic II): prepandemic: 27%, pandemic I: 19%, pandemic II: 33%; historic: 36% of collected swabs per period, p<0.001. Human rhinovirus (HRV) prevalence persisted during NPIs presence, mainly in the form of asymptomatic HRV detection: prepandemic=24%, pandemic I=19%, pandemic II=25%, historic: 25%, p=0.3. SARS-CoV-2 detection (asymptomatic and symptomatic) was low, and only present after NPIs were relaxed: pandemic II=2.4%. No severe COVID-19 infections were reported.</p><p><strong>Discussion: </strong>In our cohort, infants did not contribute largely to spread of SARS-CoV-2. The role of persisting asymptomatic HRV prevalence is still unclear, but it might help to maintain population immunity to prevent more severe infections. Our results underscore the importance of capturing asymptomatic viruses via longitudinal community-based data assessment to better understand virus transmission.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-26 DOI: 10.1136/bmjresp-2024-002718
Layan Sukik, Hiam Chemaitelly, Houssein H Ayoub, Peter Coyle, Patrick Tang, Mohammad R Hasan, Hadi M Yassine, Asmaa A Al Thani, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F Abdul-Rahim, Gheyath K Nasrallah, Mohamed Ghaith Al-Kuwari, Adeel Butt, Hamad Eid Al-Romaihi, Mohamed H Al-Thani, Abdullatif Al-Khal, Roberto Bertollini, Laith J Abu-Raddad

Background: SARS-CoV-2 infection is associated with protection against reinfection. This study analysed this protection across different reinfection symptoms and severities, comparing the preomicron and omicron eras.

Methods: A nationwide, matched, test-negative, case-control study was conducted in Qatar from 5 February 2020 to 12 March 2024. The preomicron analysis used a sample of 509 949 positive and 8 494 782 negative tests, while the omicron analysis included 682 257 positive and 6 904 044 negative tests. Data were sourced from Qatar's national databases for COVID-19 laboratory testing, vaccination, hospitalisation and death.

Results: Effectiveness of preomicron infection against preomicron reinfection was estimated at 80.9% (95% CI: 79.1% to 82.6%) for asymptomatic reinfection, 87.5% (95% CI: 86.1% to 88.9%) for symptomatic reinfection, 97.8% (95% CI: 95.7% to 98.9%) for severe COVID-19 reinfection, 100.0% (95% CI: 97.5% to 100.0%) for critical COVID-19 reinfection and 88.1% (95% CI: 50.3% to 97.2%) for fatal COVID-19 reinfection. For omicron infection against omicron reinfection, the estimates were 46.4% (95% CI: 36.9% to 54.4%) for asymptomatic reinfection, 52.8% (95% CI: 44.4% to 60.0%) for symptomatic reinfection, 100.0% (95% CI: 55.4% to 100.0%) for severe COVID-19 reinfection, 100.0% (95% CI: 15.1% to 100.0%) for critical COVID-19 reinfection, and 75.2% (95% CI: -58.8% to 97.5%) for fatal COVID-19 reinfection. Effectiveness over time since previous infection showed no discernible decline in protection against all forms of reinfection in the preomicron era, but a rapid decline against asymptomatic and symptomatic reinfections in the omicron era.

Conclusions: A gradient of protection against reinfection is evident, with the highest protection observed against severe forms of COVID-19. Over time, this gradient becomes more pronounced, as protection against asymptomatic and symptomatic reinfections decreases, while protection against severe outcomes remains strong.

背景:SARS-CoV-2感染与防止再感染有关。本研究分析了不同再感染症状和严重程度下的这种保护作用,并对前微粒期和后微粒期进行了比较:方法:2020 年 2 月 5 日至 2024 年 3 月 12 日,在卡塔尔开展了一项全国性、匹配、检测阴性的病例对照研究。前原子周期分析使用的样本包括 509 949 次阳性检测和 8 494 782 次阴性检测,而后原子周期分析包括 682 257 次阳性检测和 6 904 044 次阴性检测。数据来源于卡塔尔的 COVID-19 实验室检测、疫苗接种、住院和死亡国家数据库:对无症状再感染、有症状再感染和无症状再感染的有效率分别估计为 80.9% (95% CI: 79.1% to 82.6%)、87.5% (95% CI: 86.1% to 88.9%)、97.8% (95% CI: 95% CI) 和 97.8% (95% CI: 95% CI) 。8%(95% CI:95.7% 至 98.9%),危重 COVID-19 再感染为 100.0%(95% CI:97.5% 至 100.0%),致命 COVID-19 再感染为 88.1%(95% CI:50.3% 至 97.2%)。对于奥米克感染与奥米克再感染,无症状再感染的估计值为 46.4%(95% CI:36.9% 至 54.4%),有症状再感染的估计值为 52.8%(95% CI:44.4% 至 60.0%),100.重度 COVID-19 再感染的有效率为 100.0%(95% CI:55.4% 至 100.0%),危重 COVID-19 再感染的有效率为 100.0%(95% CI:15.1% 至 100.0%),致命 COVID-19 再感染的有效率为 75.2%(95% CI:-58.8% 至 97.5%)。自上次感染以来,随着时间的推移,在前微粒体时代,对各种形式再感染的保护效果没有明显下降,但在欧微粒体时代,对无症状和有症状再感染的保护效果迅速下降:结论:针对再感染的保护梯度是显而易见的,针对严重形式的 COVID-19 的保护率最高。随着时间的推移,这种梯度变得更加明显,对无症状和有症状再感染的保护作用下降,而对严重后果的保护作用仍然很强。
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引用次数: 0
Psychosocial experience of living with severe and uncontrolled asthma as a young adult: a qualitative synthesis. 年轻时患有严重且无法控制的哮喘的社会心理体验:定性综述。
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-22 DOI: 10.1136/bmjresp-2024-002541
Leanne-Jo Holmes, Siobhan Ludlow, Stephen Fowler, Marie Marshall, Karina Lovell

Background: Living with severe and uncontrolled asthma can negatively impact on well-being, yet little is known about the psychosocial impact on young adults (age 12-25).

Aim: To identify, appraise and synthesise current literature pertaining to the psychosocial experience of living with severe and uncontrolled asthma as a young adult, to generate new knowledge, further conceptual understanding and provide recommendations to help improve long-term outcomes.

Methods: We followed a predefined protocol, registered on PROSPERO. We systematically searched for qualitative research which captured the psychosocial impact of living with severe and uncontrolled asthma as a young adult. Using thematic synthesis, data was coded and developed into descriptive and analytical themes.

Results: 10 studies with 219 participants were identified and included in the synthesis. 73 codes were then developed into 17 descriptive themes, subsequently forming 5 analytical themes: 'Living with a constant uncertainty', 'The deleterious impact of asthma', 'Acquiescence', 'A need for support & understanding' and 'The constraints of living with asthma'.Young adults with severe and uncontrolled asthma live with a significant negative impact on their psychosocial well-being. Reported emotions described living with a burden of shame, embarrassment, anxiety, isolation, uncertainty, fear, conflict, lack of control, restriction on life choices and a perceived desire to be normal. These emotions influenced lifestyle choices and adherence to treatment, compounding on physical symptomology. This resulted in a cyclical interplay between the physical and psychological impact of living with severe and uncontrolled asthma.

Conclusion: There is clear evidence of a negative psychosocial impact of living with severe and uncontrolled asthma as a young adult. We have also highlighted the paucity of recent literature and provide the rationale for further research, to increase our understanding of the impact and support requirements of young adults with severe asthma to help improve long-term outcomes and quality of life.

Prospero registration number: CRD42022363201.

{"title":"Psychosocial experience of living with severe and uncontrolled asthma as a young adult: a qualitative synthesis.","authors":"Leanne-Jo Holmes, Siobhan Ludlow, Stephen Fowler, Marie Marshall, Karina Lovell","doi":"10.1136/bmjresp-2024-002541","DOIUrl":"10.1136/bmjresp-2024-002541","url":null,"abstract":"<p><strong>Background: </strong>Living with severe and uncontrolled asthma can negatively impact on well-being, yet little is known about the psychosocial impact on young adults (age 12-25).</p><p><strong>Aim: </strong>To identify, appraise and synthesise current literature pertaining to the psychosocial experience of living with severe and uncontrolled asthma as a young adult, to generate new knowledge, further conceptual understanding and provide recommendations to help improve long-term outcomes.</p><p><strong>Methods: </strong>We followed a predefined protocol, registered on PROSPERO. We systematically searched for qualitative research which captured the psychosocial impact of living with severe and uncontrolled asthma as a young adult. Using thematic synthesis, data was coded and developed into descriptive and analytical themes.</p><p><strong>Results: </strong>10 studies with 219 participants were identified and included in the synthesis. 73 codes were then developed into 17 descriptive themes, subsequently forming 5 analytical themes: 'Living with a constant uncertainty', 'The deleterious impact of asthma', 'Acquiescence', 'A need for support & understanding' and 'The constraints of living with asthma'.Young adults with severe and uncontrolled asthma live with a significant negative impact on their psychosocial well-being. Reported emotions described living with a burden of shame, embarrassment, anxiety, isolation, uncertainty, fear, conflict, lack of control, restriction on life choices and a perceived desire to be normal. These emotions influenced lifestyle choices and adherence to treatment, compounding on physical symptomology. This resulted in a cyclical interplay between the physical and psychological impact of living with severe and uncontrolled asthma.</p><p><strong>Conclusion: </strong>There is clear evidence of a negative psychosocial impact of living with severe and uncontrolled asthma as a young adult. We have also highlighted the paucity of recent literature and provide the rationale for further research, to increase our understanding of the impact and support requirements of young adults with severe asthma to help improve long-term outcomes and quality of life.</p><p><strong>Prospero registration number: </strong>CRD42022363201.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning-based model for predicting all-cause mortality in severe pneumonia. 基于机器学习的重症肺炎全因死亡率预测模型
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-22 DOI: 10.1136/bmjresp-2023-001983
Weichao Zhao, Xuyan Li, Lianjun Gao, Zhuang Ai, Yaping Lu, Jiachen Li, Dong Wang, Xinlou Li, Nan Song, Xuan Huang, Zhao-Hui Tong
<p><strong>Background: </strong>Severe pneumonia has a poor prognosis and high mortality. Current severity scores such as Acute Physiology and Chronic Health Evaluation (APACHE-II) and Sequential Organ Failure Assessment (SOFA), have limited ability to help clinicians in classification and management decisions. The goal of this study was to analyse the clinical characteristics of severe pneumonia and develop a machine learning-based mortality-prediction model for patients with severe pneumonia.</p><p><strong>Methods: </strong>Consecutive patients with severe pneumonia between 2013 and 2022 admitted to Beijing Chaoyang Hospital affiliated with Capital Medical University were included. In-hospital all-cause mortality was the outcome of this study. We performed a retrospective analysis of the cohort, stratifying patients into survival and non-survival groups, using mainstream machine learning algorithms (light gradient boosting machine, support vector classifier and random forest). We aimed to construct a mortality-prediction model for patients with severe pneumonia based on their accessible clinical and laboratory data. The discriminative ability was evaluated using the area under the receiver operating characteristic curve (AUC). The calibration curve was used to assess the fit goodness of the model, and decision curve analysis was performed to quantify clinical utility. By means of logistic regression, independent risk factors for death in severe pneumonia were figured out to provide an important basis for clinical decision-making.</p><p><strong>Results: </strong>A total of 875 patients were included in the development and validation cohorts, with the in-hospital mortality rate of 14.6%. The AUC of the model in the internal validation set was 0.8779 (95% CI, 0.738 to 0.974), showing a competitive discrimination ability that outperformed those of traditional clinical scoring systems, that is, APACHE-II, SOFA, CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥65 years), Pneumonia Severity Index. The calibration curve showed that the in-hospital mortality in severe pneumonia predicted by the model fit reasonably with the actual hospital mortality. In addition, the decision curve showed that the net clinical benefit was positive in both training and validation sets of hospitalised patients with severe pneumonia. Based on ensemble machine learning algorithms and logistic regression technique, the level of ferritin, lactic acid, blood urea nitrogen, creatine kinase, eosinophil and the requirement of vasopressors were identified as top independent predictors of in-hospital mortality with severe pneumonia.</p><p><strong>Conclusion: </strong>A robust clinical model for predicting the risk of in-hospital mortality after severe pneumonia was successfully developed using machine learning techniques. The performance of this model demonstrates the effectiveness of these techniques in creating accurate predictive models, and the use of this model
背景:重症肺炎预后差、死亡率高。目前的严重程度评分,如急性生理学和慢性健康评估(APACHE-II)和序贯器官衰竭评估(SOFA),在帮助临床医生进行分类和管理决策方面能力有限。本研究旨在分析重症肺炎的临床特征,并为重症肺炎患者开发基于机器学习的死亡率预测模型:方法:纳入首都医科大学附属北京朝阳医院 2013 年至 2022 年期间收治的重症肺炎患者。院内全因死亡率是本研究的结果。我们使用主流机器学习算法(轻梯度提升机、支持向量分类器和随机森林)对队列进行了回顾性分析,将患者分为存活组和非存活组。我们的目标是根据可获得的临床和实验室数据,为重症肺炎患者构建一个死亡率预测模型。使用接收者工作特征曲线下面积(AUC)评估了判别能力。校准曲线用于评估模型的拟合优度,决策曲线分析用于量化临床效用。通过逻辑回归,找出重症肺炎死亡的独立风险因素,为临床决策提供重要依据:结果:开发组和验证组共纳入了 875 名患者,院内死亡率为 14.6%。该模型在内部验证组中的AUC为0.8779(95% CI,0.738至0.974),显示出优于传统临床评分系统(即APACHE-II、SOFA、CURB-65(混淆、尿素、呼吸频率、血压、年龄≥65岁)、肺炎严重程度指数)的竞争性判别能力。校准曲线显示,模型预测的重症肺炎院内死亡率与实际住院死亡率相当吻合。此外,决策曲线显示,在重症肺炎住院患者的训练集和验证集中,临床净获益均为正值。基于集合机器学习算法和逻辑回归技术,铁蛋白、乳酸、血尿素氮、肌酸激酶、嗜酸性粒细胞和血管加压剂需求水平被确定为重症肺炎住院死亡率的首要独立预测因素:结论:利用机器学习技术,成功开发出了一种预测重症肺炎院内死亡风险的可靠临床模型。该模型的表现证明了这些技术在创建精确预测模型方面的有效性,而且该模型的使用有可能极大地帮助患者和临床医生在患者护理方面做出明智的决定。
{"title":"Machine learning-based model for predicting all-cause mortality in severe pneumonia.","authors":"Weichao Zhao, Xuyan Li, Lianjun Gao, Zhuang Ai, Yaping Lu, Jiachen Li, Dong Wang, Xinlou Li, Nan Song, Xuan Huang, Zhao-Hui Tong","doi":"10.1136/bmjresp-2023-001983","DOIUrl":"10.1136/bmjresp-2023-001983","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Severe pneumonia has a poor prognosis and high mortality. Current severity scores such as Acute Physiology and Chronic Health Evaluation (APACHE-II) and Sequential Organ Failure Assessment (SOFA), have limited ability to help clinicians in classification and management decisions. The goal of this study was to analyse the clinical characteristics of severe pneumonia and develop a machine learning-based mortality-prediction model for patients with severe pneumonia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Consecutive patients with severe pneumonia between 2013 and 2022 admitted to Beijing Chaoyang Hospital affiliated with Capital Medical University were included. In-hospital all-cause mortality was the outcome of this study. We performed a retrospective analysis of the cohort, stratifying patients into survival and non-survival groups, using mainstream machine learning algorithms (light gradient boosting machine, support vector classifier and random forest). We aimed to construct a mortality-prediction model for patients with severe pneumonia based on their accessible clinical and laboratory data. The discriminative ability was evaluated using the area under the receiver operating characteristic curve (AUC). The calibration curve was used to assess the fit goodness of the model, and decision curve analysis was performed to quantify clinical utility. By means of logistic regression, independent risk factors for death in severe pneumonia were figured out to provide an important basis for clinical decision-making.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 875 patients were included in the development and validation cohorts, with the in-hospital mortality rate of 14.6%. The AUC of the model in the internal validation set was 0.8779 (95% CI, 0.738 to 0.974), showing a competitive discrimination ability that outperformed those of traditional clinical scoring systems, that is, APACHE-II, SOFA, CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥65 years), Pneumonia Severity Index. The calibration curve showed that the in-hospital mortality in severe pneumonia predicted by the model fit reasonably with the actual hospital mortality. In addition, the decision curve showed that the net clinical benefit was positive in both training and validation sets of hospitalised patients with severe pneumonia. Based on ensemble machine learning algorithms and logistic regression technique, the level of ferritin, lactic acid, blood urea nitrogen, creatine kinase, eosinophil and the requirement of vasopressors were identified as top independent predictors of in-hospital mortality with severe pneumonia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A robust clinical model for predicting the risk of in-hospital mortality after severe pneumonia was successfully developed using machine learning techniques. The performance of this model demonstrates the effectiveness of these techniques in creating accurate predictive models, and the use of this model","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Head-to-head comparison of anterior nares and nasopharyngeal swabs for SARS-CoV-2 antigen detection in a community drive-through test centre in the UK.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-22 DOI: 10.1136/bmjresp-2023-001747
Rachel L Byrne, Ghaith Aljayyoussi, Konstantina Kontogianni, Karina Clerkin, Mathew McIntyre, Jahanara Wardale, Christopher T Williams, Richard Body, Emily R Adams, Margaretha de Vos, Camille Escadafal, Ana I Cubas Atienzar

Objective: To conduct a head-to-head diagnostic accuracy evaluation of anterior nares (AN) and nasopharyngeal (NP) swabs for SARS-CoV-2 antigen detection using two brands of rapid diagnostic tests (Ag-RDT).

Methods: Two prospective diagnostic evaluations were carried out at different time points and participant cohorts to evaluate the performance of paired AN and NP swabs in two Ag-RDT brands: Sure-Status (PMC, India) and Biocredit (RapiGEN, South Korea). The sensitivity and specificity of AN and NP swabs for each of the index test cohorts were calculated against the reverse transcription quantitative PCR (RT-qPCR) TaqPath COVID-19 (ThermoFisher, UK) using NP swabs as reference standard.

Results: A total of 372 participants were recruited for the Sure-Status cohort and 232 for the Biocredit, of which 119 (32.1%) and 122 (53.7%) were SARS-CoV-2 positive by RT-qPCR, respectively. Sensitivity and specificity of AN swabs were equivalent to those obtained with NP swabs in both cohorts: 83.9% (95% CI 76.0-90.0) and 98.8% (95% CI 96.6-9.8) using NP swabs and 85.6% (95% CI 77.1-91.4) and 99.2% (95% CI 97.1-99.9) with AN swabs for Sure-Status and; 81.2% (95% CI 73.1-87.7) and 99.0% (95% CI 94.7-86.5) with NP swabs and 79.5% (95% CI 71.3-86.3) and 100% (95% CI 96.5-100) with AN swabs for Biocredit. The agreement of the AN and NP swabs was high for both brands with an inter-rater reliability (κ) of 0.918 and 0.833 for Sure-Status and Biocredit, respectively. The overall 50% limits of detection (LoD50) and 95% LoD (LoD95) were 0.9-2.4×104 and 3.0-3.2×108 RNA copies/mL for NP swabs and 0.3-1.1×105 and 0.7-7.9×107 RNA copies/mL for AN swabs, with no significant difference in LoD for any of the swab types or test brands.

Conclusions: The diagnostic accuracy of the two SARS-CoV-2 Ag-RDT brands evaluated in this study was equivalent using AN swabs than NP swabs. However, test line intensity was lower when using AN swabs, which could negatively influence the interpretation of the Ag-RDT results by lay users.

Trail registration number: NCT04408170.

{"title":"Head-to-head comparison of anterior nares and nasopharyngeal swabs for SARS-CoV-2 antigen detection in a community drive-through test centre in the UK.","authors":"Rachel L Byrne, Ghaith Aljayyoussi, Konstantina Kontogianni, Karina Clerkin, Mathew McIntyre, Jahanara Wardale, Christopher T Williams, Richard Body, Emily R Adams, Margaretha de Vos, Camille Escadafal, Ana I Cubas Atienzar","doi":"10.1136/bmjresp-2023-001747","DOIUrl":"10.1136/bmjresp-2023-001747","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a head-to-head diagnostic accuracy evaluation of anterior nares (AN) and nasopharyngeal (NP) swabs for SARS-CoV-2 antigen detection using two brands of rapid diagnostic tests (Ag-RDT).</p><p><strong>Methods: </strong>Two prospective diagnostic evaluations were carried out at different time points and participant cohorts to evaluate the performance of paired AN and NP swabs in two Ag-RDT brands: Sure-Status (PMC, India) and Biocredit (RapiGEN, South Korea). The sensitivity and specificity of AN and NP swabs for each of the index test cohorts were calculated against the reverse transcription quantitative PCR (RT-qPCR) TaqPath COVID-19 (ThermoFisher, UK) using NP swabs as reference standard.</p><p><strong>Results: </strong>A total of 372 participants were recruited for the Sure-Status cohort and 232 for the Biocredit, of which 119 (32.1%) and 122 (53.7%) were SARS-CoV-2 positive by RT-qPCR, respectively. Sensitivity and specificity of AN swabs were equivalent to those obtained with NP swabs in both cohorts: 83.9% (95% CI 76.0-90.0) and 98.8% (95% CI 96.6-9.8) using NP swabs and 85.6% (95% CI 77.1-91.4) and 99.2% (95% CI 97.1-99.9) with AN swabs for Sure-Status and; 81.2% (95% CI 73.1-87.7) and 99.0% (95% CI 94.7-86.5) with NP swabs and 79.5% (95% CI 71.3-86.3) and 100% (95% CI 96.5-100) with AN swabs for Biocredit. The agreement of the AN and NP swabs was high for both brands with an inter-rater reliability (κ) of 0.918 and 0.833 for Sure-Status and Biocredit, respectively. The overall 50% limits of detection (LoD50) and 95% LoD (LoD95) were 0.9-2.4×10<sup>4</sup> and 3.0-3.2×10<sup>8</sup> RNA copies/mL for NP swabs and 0.3-1.1×10<sup>5</sup> and 0.7-7.9×10<sup>7</sup> RNA copies/mL for AN swabs, with no significant difference in LoD for any of the swab types or test brands.</p><p><strong>Conclusions: </strong>The diagnostic accuracy of the two SARS-CoV-2 Ag-RDT brands evaluated in this study was equivalent using AN swabs than NP swabs. However, test line intensity was lower when using AN swabs, which could negatively influence the interpretation of the Ag-RDT results by lay users.</p><p><strong>Trail registration number: </strong>NCT04408170.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-22 DOI: 10.1136/bmjresp-2024-002327
Michael George Crooks, Caroline Wright, Simon Hart, Victoria Allgar, Anne English, Flavia Swan, Judith Dyson, Gerry Richardson, Maureen Twiddy, Judith Cohen, Andrew Simpson, Chao Huang, Dominic L Sykes, Miriam Johnson

Introduction: Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-methods, randomised controlled, feasibility study of a complex breathlessness intervention in breathless IPF and non-IPF fibrotic ILD patients.

Methods: Breathless IPF and non-IPF fibrotic ILD patients were randomised to receive the intervention within 1 week (fast-track) or after 8 weeks (wait-list). The intervention comprised two face-to-face and one telephone appointment during a 3-week period covering breathing control, handheld fan-use, pacing and breathlessness management techniques, and techniques to manage anxiety. Feasibility and clinical outcomes were assessed to inform progression to, and optimal design for, a definitive trial. A qualitative substudy explored barriers and facilitators to trial and intervention delivery.

Results: 47 patients (M:F 38:9, mean (SD) age 73.9 (7.2)) were randomised with a recruitment rate of 2.5 participants per month across three sites. The adjusted mean differences (95% CI) for key clinical outcomes at 4 weeks post randomisation were as follows: Chronic Respiratory Questionnaire breathlessness mastery domain (0.45 (-0.07, 0.97)); and numerical rating scales for 'worst' (-0.93 (-1.95, 0.10)), 'best' (-0.19 (-1.38, 1.00)), 'distress caused by' (-1.84 (-3.29, -0.39)) and 'ability to cope with' (0.71 (-0.57, 1.99)) breathlessness within the past 24 hours. The qualitative substudy confirmed intervention acceptability and informed feasibility and acceptability of study outcome measures.

Conclusion: A definitive trial of a complex breathlessness intervention in patients with IPF and non-IPF fibrotic ILD is feasible with preliminary data supporting intervention effectiveness.

Trial registration number: ISRCTN13784514.

简介:憋气是特发性肺纤维化(IPF)和非 IPF 纤维化间质性肺病(ILD)患者的常见病,会影响他们的生活质量。我们报告了一项多中心、快速通道(候补名单)、混合方法、随机对照、可行性研究的结果,该研究针对憋气的 IPF 和非 IPF 纤维化 ILD 患者进行了复杂的憋气干预:呼吸困难的 IPF 和非 IPF 纤维化 ILD 患者被随机分配到 1 周内(快速通道)或 8 周后(候补名单)接受干预。干预措施包括在 3 周内进行两次面对面交流和一次电话预约,内容包括呼吸控制、手持风扇的使用、起搏和呼吸困难管理技巧以及焦虑管理技巧。对可行性和临床结果进行了评估,以便为最终试验的进展和优化设计提供依据。一项定性子研究探讨了进行试验和干预的障碍和促进因素:47 名患者(男女比例为 38:9,平均(标清)年龄为 73.9 (7.2))被随机分配到三个地点,招募率为每月 2.5 人。随机化后 4 周的主要临床结果的调整后平均差异(95% CI)如下:过去 24 小时内 "最严重"(-0.93 (-1.95, 0.10))、"最严重"(-0.19 (-1.38, 1.00))、"造成的痛苦"(-1.84 (-3.29, -0.39))和 "应对能力"(0.71 (-0.57, 1.99))呼吸困难的数字评分量表。定性子研究证实了干预的可接受性,并告知了研究结果测量的可行性和可接受性:在 IPF 和非 IPF 纤维化 ILD 患者中进行复杂呼吸困难干预的最终试验是可行的,初步数据支持干预的有效性。
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引用次数: 0
Sex differences in asthma and COPD hospital admission, readmission and mortality. 哮喘和慢性阻塞性肺病入院、再入院和死亡率的性别差异。
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-17 DOI: 10.1136/bmjresp-2024-002808
Hannah Whittaker, Alexander Adamson, Philip Stone, Precious Olubori, James Calvert, James Dodd, Ian Sinha, Katherine Hickman, Sally Singh, Jennifer K Quint

Background: Asthma and chronic obstructive pulmonary disease (COPD) outcomes vary by sex. We investigated whether males and females with asthma or COPD are managed differently in-hospital when admitted for an exacerbation.

Methods: Data from the National Asthma and COPD Audit Programme were used to determine three cohorts of people hospitalised for an exacerbation: (1) adults with asthma, (2) children and young people (CYP) with asthma, and (3) adults with COPD. Outcomes included the following in-hospital interventional measures: spirometry recording, respiratory specialist review, respiratory medication administration and discharge bundle recording. Linked hospital data were used to determine 30-day and 90-day readmissions and Office for National Statistics data for 90-day mortality. Random effects logistic regression was used to investigate the association between sex and in-hospital outcomes, readmission and mortality.

Results: 16 370 adults with asthma, 7156 CYP with asthma and 28 354 adults with COPD were included. Female adults with asthma had higher odds of being seen by a respiratory specialist (aOR 0.1.13, 1.02-1.26) and higher odds of readmission within 30 and 90 days (aOR 1.22, 1.10-1.37, aOR 1.34, 1.23-1.46) compared with males. Female adults with COPD had higher odds of being seen by a respiratory specialist, (aOR 1.10,1.02-1.19), being administered non-invasive ventilation (aOR 1.18, 1.09-1.29), and receiving a discharge bundle (aOR 1.07, 1.00-1.14), and lower odds of readmission within 90 days (aOR 0.95, 0.90-1.01), or mortality within 90 days (aOR 0.88, 0.81-0.96). Lastly, female CYP had higher odds of steroids administered within 1 hour (aOR 1.13, 1.00-1.28) and higher 30-day and 90-day readmission compared with males (aOR 1.21, 1.00-1.44 and 1.17, 1.03-1.34).

Interpretation: Sex differences in in-hospital care exist in adults COPD, which may impact readmissions and mortality; however, little to no sex differences in in-hospital care were seen in people with asthma yet females were more likely to be readmitted to hospital.

{"title":"Sex differences in asthma and COPD hospital admission, readmission and mortality.","authors":"Hannah Whittaker, Alexander Adamson, Philip Stone, Precious Olubori, James Calvert, James Dodd, Ian Sinha, Katherine Hickman, Sally Singh, Jennifer K Quint","doi":"10.1136/bmjresp-2024-002808","DOIUrl":"10.1136/bmjresp-2024-002808","url":null,"abstract":"<p><strong>Background: </strong>Asthma and chronic obstructive pulmonary disease (COPD) outcomes vary by sex. We investigated whether males and females with asthma or COPD are managed differently in-hospital when admitted for an exacerbation.</p><p><strong>Methods: </strong>Data from the National Asthma and COPD Audit Programme were used to determine three cohorts of people hospitalised for an exacerbation: (1) adults with asthma, (2) children and young people (CYP) with asthma, and (3) adults with COPD. Outcomes included the following in-hospital interventional measures: spirometry recording, respiratory specialist review, respiratory medication administration and discharge bundle recording. Linked hospital data were used to determine 30-day and 90-day readmissions and Office for National Statistics data for 90-day mortality. Random effects logistic regression was used to investigate the association between sex and in-hospital outcomes, readmission and mortality.</p><p><strong>Results: </strong>16 370 adults with asthma, 7156 CYP with asthma and 28 354 adults with COPD were included. Female adults with asthma had higher odds of being seen by a respiratory specialist (<sub>a</sub>OR 0.1.13, 1.02-1.26) and higher odds of readmission within 30 and 90 days (<sub>a</sub>OR 1.22, 1.10-1.37, <sub>a</sub>OR 1.34, 1.23-1.46) compared with males. Female adults with COPD had higher odds of being seen by a respiratory specialist, (<sub>a</sub>OR 1.10,1.02-1.19), being administered non-invasive ventilation (<sub>a</sub>OR 1.18, 1.09-1.29), and receiving a discharge bundle (<sub>a</sub>OR 1.07, 1.00-1.14), and lower odds of readmission within 90 days (<sub>a</sub>OR 0.95, 0.90-1.01), or mortality within 90 days (<sub>a</sub>OR 0.88, 0.81-0.96). Lastly, female CYP had higher odds of steroids administered within 1 hour (<sub>a</sub>OR 1.13, 1.00-1.28) and higher 30-day and 90-day readmission compared with males (<sub>a</sub>OR 1.21, 1.00-1.44 and 1.17, 1.03-1.34).</p><p><strong>Interpretation: </strong>Sex differences in in-hospital care exist in adults COPD, which may impact readmissions and mortality; however, little to no sex differences in in-hospital care were seen in people with asthma yet females were more likely to be readmitted to hospital.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the right ventricular strain, left ventricular strain and left atrial strain using speckle tracking echocardiography in patients with chronic obstructive pulmonary disease.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-06 DOI: 10.1136/bmjresp-2024-002706
Hai Nguyen Ngoc Dang, Thang Viet Luong, Nhi Thi Y Nguyen, Hung Khanh Tran, Hieu Thi Nguyen Tran, Hung Minh Vu, Thanh Van Ho, Ngoc Thi Minh Vo, Thanh Thien Tran, Toan Song Do, Van Thi Thuy Phan, Tien Anh Hoang, Phuoc Le Huu, Binh Anh Ho, Hung Minh Nguyen

Objectives: Cardiovascular disease is a prevalent comorbidity and leading cause of mortality in chronic obstructive pulmonary disease (COPD) patients. Early identification of cardiac abnormalities in COPD patients is crucial. Speckle tracking echocardiography (STE) is practical for assessing ventricular and atrial function, but its role in COPD patients is under-researched. This study aimed to examine right ventricular (RV), left ventricular (LV) and left atrial (LA) strain in COPD patients via STE.

Methods: A cross-sectional study was conducted with two groups: COPD patients diagnosed per the 2017 Global Initiative for Chronic Obstructive Lung Disease criteria and healthy controls. All the participants underwent STE to evaluate the RV, LV, and LA strains.

Results: RV strain indices (RV free wall longitudinal strain (RVFWSL) and RV 4-chamber longitudinal strain (RV4CSL)) were significantly lower in the COPD group (16.53±5.89% and 14.65±4.53%, respectively) than in the control group (21.39±7.78% and 18.34±6.38%, respectively) (p<0.001). LV global longitudinal strain was also lower in the COPD group (18.45% (17.16-19.51)) than in the control group (19.50% (18.63-21.46), p=0.018). No significant differences were found in LA strain indices (LA reservoir strain, LA conduit strain or LA contractile strain) between the two groups. Furthermore, RVFWSL and RV4CSL were significantly greater in the group with a modified Medical Research Council score <2 (p<0.05).

Conclusion: Compared with healthy controls, COPD patients presented reduced RV and LV strain, with no significant differences in LA strain indices.

{"title":"Assessment of the right ventricular strain, left ventricular strain and left atrial strain using speckle tracking echocardiography in patients with chronic obstructive pulmonary disease.","authors":"Hai Nguyen Ngoc Dang, Thang Viet Luong, Nhi Thi Y Nguyen, Hung Khanh Tran, Hieu Thi Nguyen Tran, Hung Minh Vu, Thanh Van Ho, Ngoc Thi Minh Vo, Thanh Thien Tran, Toan Song Do, Van Thi Thuy Phan, Tien Anh Hoang, Phuoc Le Huu, Binh Anh Ho, Hung Minh Nguyen","doi":"10.1136/bmjresp-2024-002706","DOIUrl":"10.1136/bmjresp-2024-002706","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiovascular disease is a prevalent comorbidity and leading cause of mortality in chronic obstructive pulmonary disease (COPD) patients. Early identification of cardiac abnormalities in COPD patients is crucial. Speckle tracking echocardiography (STE) is practical for assessing ventricular and atrial function, but its role in COPD patients is under-researched. This study aimed to examine right ventricular (RV), left ventricular (LV) and left atrial (LA) strain in COPD patients via STE.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with two groups: COPD patients diagnosed per the 2017 Global Initiative for Chronic Obstructive Lung Disease criteria and healthy controls. All the participants underwent STE to evaluate the RV, LV, and LA strains.</p><p><strong>Results: </strong>RV strain indices (RV free wall longitudinal strain (RVFWSL) and RV 4-chamber longitudinal strain (RV4CSL)) were significantly lower in the COPD group (16.53±5.89% and 14.65±4.53%, respectively) than in the control group (21.39±7.78% and 18.34±6.38%, respectively) (p<0.001). LV global longitudinal strain was also lower in the COPD group (18.45% (17.16-19.51)) than in the control group (19.50% (18.63-21.46), p=0.018). No significant differences were found in LA strain indices (LA reservoir strain, LA conduit strain or LA contractile strain) between the two groups. Furthermore, RVFWSL and RV4CSL were significantly greater in the group with a modified Medical Research Council score <2 (p<0.05).</p><p><strong>Conclusion: </strong>Compared with healthy controls, COPD patients presented reduced RV and LV strain, with no significant differences in LA strain indices.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleural procedural safety in the UK: is everyone's house in order? Reflections from the BTS National Pleural Service Organisational Audit and a national review of patient safety incidents.
IF 3.6 3区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-03-02 DOI: 10.1136/bmjresp-2024-002840
Andrew Ewing Stanton, Mark Juniper, Eihab Bedawi, Laura McNaughton, Amelia O Clive, Duneesha De Fonseka, Avinash Aujayeb, Matthew Evison

Introduction: The 2022 British Thoracic Society Pleural Services Organisational Audit highlighted evidence of ongoing risk of harm from pleural procedures. To better understand the underlying causes of these safety concerns we undertook a review of patient safety incidents from the National Reporting and Learning System (NRLS).

Methods: Incident-level patient safety data from NRLS were requested from any level 3, 4 and 5 incidents describing harm resulting from pleural intervention, specifically chest drain insertion or pleural aspiration for pleural effusions (fluid), submitted between 1 April 2018 and 30 March 2022.

Results: 256 incidents were identified. Most of these did not directly relate to a pleural procedure or its concerns and so were excluded. Ultimately, 21 incidents (including 2 deaths) were relevant. 17 involved direct organ puncture, predominantly liver (n= 13). 11 incidents involved seldinger drains, 5 blunt dissection drains and 1 involved both (not specified in 4). In only four incidents was it clearly detailed that an ultrasound-assisted approach had been used. In the remainder, the use of ultrasound was largely not detailed at all, or the approach used was not clear or inappropriate. Most (19/21) events occurred out with respiratory environments.

Discussion: These data raise concerns about pleural intervention for fluid occurring where lack of appropriate ultrasound use may have contributed in a variety of clinical areas. This should be highlighted at a national level by specialty groups and societies. We welcome an upcoming National Confidential Enquiry into Patient Outcome and Death study to help cement our understanding of factors underlying this ongoing risk of harm and to enable definitive action to be taken to reduce this risk.

{"title":"Pleural procedural safety in the UK: is everyone's house in order? Reflections from the BTS National Pleural Service Organisational Audit and a national review of patient safety incidents.","authors":"Andrew Ewing Stanton, Mark Juniper, Eihab Bedawi, Laura McNaughton, Amelia O Clive, Duneesha De Fonseka, Avinash Aujayeb, Matthew Evison","doi":"10.1136/bmjresp-2024-002840","DOIUrl":"10.1136/bmjresp-2024-002840","url":null,"abstract":"<p><strong>Introduction: </strong>The 2022 British Thoracic Society Pleural Services Organisational Audit highlighted evidence of ongoing risk of harm from pleural procedures. To better understand the underlying causes of these safety concerns we undertook a review of patient safety incidents from the National Reporting and Learning System (NRLS).</p><p><strong>Methods: </strong>Incident-level patient safety data from NRLS were requested from any level 3, 4 and 5 incidents describing harm resulting from pleural intervention, specifically chest drain insertion or pleural aspiration for pleural effusions (fluid), submitted between 1 April 2018 and 30 March 2022.</p><p><strong>Results: </strong>256 incidents were identified. Most of these did not directly relate to a pleural procedure or its concerns and so were excluded. Ultimately, 21 incidents (including 2 deaths) were relevant. 17 involved direct organ puncture, predominantly liver (n= 13). 11 incidents involved seldinger drains, 5 blunt dissection drains and 1 involved both (not specified in 4). In only four incidents was it clearly detailed that an ultrasound-assisted approach had been used. In the remainder, the use of ultrasound was largely not detailed at all, or the approach used was not clear or inappropriate. Most (19/21) events occurred out with respiratory environments.</p><p><strong>Discussion: </strong>These data raise concerns about pleural intervention for fluid occurring where lack of appropriate ultrasound use may have contributed in a variety of clinical areas. This should be highlighted at a national level by specialty groups and societies. We welcome an upcoming National Confidential Enquiry into Patient Outcome and Death study to help cement our understanding of factors underlying this ongoing risk of harm and to enable definitive action to be taken to reduce this risk.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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BMJ Open Respiratory Research
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