Detection of hypertension from pharyngeal images using deep learning algorithm in primary care settings in Japan.

IF 4.1 Q1 HEALTH CARE SCIENCES & SERVICES BMJ Health & Care Informatics Pub Date : 2024-10-23 DOI:10.1136/bmjhci-2023-100824
Hiroshi Yoshihara, Yusuke Tsugawa, Memori Fukuda, Sho Okiyama, Takeo Nakayama
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Abstract

Background: The early detection of hypertension using simple visual images in a way that does not require physical interaction or additional devices may improve quality of care in the era of telemedicine. Pharyngeal images include vascular morphological information and may therefore be useful for identifying hypertension.

Objectives: This study sought to develop a deep learning-based artificial intelligence algorithm for identifying hypertension from pharyngeal images.

Methods: We conducted a secondary analysis of data from a clinical trial, in which demographic information, vital signs and pharyngeal images were obtained from patients with influenza-like symptoms in multiple primary care clinics in Japan. A deep learning-based algorithm that included a multi-instance convolutional neural network was trained to detect hypertension from pharyngeal images and demographic information. The classification performance was measured by area under the receiver operating characteristic curve. Importance heatmaps of the convolutional neural network were also examined to interpret the algorithm.

Results: This study included 7710 patients from 64 clinics. The training dataset comprised 6171 patients from 51 clinics (460 positive cases), and the test dataset comprised 1539 patients from 13 clinics (130 positive cases). Our algorithm achieved an area under the receiver operating characteristic curve of 0.922 (95% CI, 0.904 to 0.940), significantly improving over the baseline prediction model incorporating only demographic information, which scored 0.887 (95% CI, 0.862 to 0.911). Our algorithm had consistent classification performance across all age and sex subgroups. Importance heatmaps revealed that the algorithm focused on the posterior pharyngeal wall area, where blood vessels are mainly located.

Conclusions: The results indicate that a deep learning-based algorithm can detect hypertension with high accuracy using pharyngeal images.

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日本基层医疗机构利用深度学习算法从咽部图像检测高血压。
背景:在远程医疗时代,利用简单的视觉图像进行高血压的早期检测,无需身体互动或额外设备,可提高医疗质量。咽部图像包括血管形态信息,因此可能有助于识别高血压:本研究试图开发一种基于深度学习的人工智能算法,用于从咽部图像中识别高血压:我们对一项临床试验的数据进行了二次分析,该试验从日本多家初级保健诊所的流感样症状患者那里获得了人口统计学信息、生命体征和咽部图像。我们训练了一种基于深度学习的算法,其中包括一个多实例卷积神经网络,用于从咽部图像和人口统计学信息中检测高血压。分类性能通过接收者工作特征曲线下面积进行测量。此外,还研究了卷积神经网络的重要性热图,以解释该算法:这项研究包括来自 64 家诊所的 7710 名患者。训练数据集包括 51 家诊所的 6171 名患者(460 个阳性病例),测试数据集包括 13 家诊所的 1539 名患者(130 个阳性病例)。我们的算法的接收者操作特征曲线下面积为 0.922(95% CI,0.904 至 0.940),明显优于仅包含人口统计学信息的基线预测模型,后者的得分为 0.887(95% CI,0.862 至 0.911)。在所有年龄和性别分组中,我们的算法都具有一致的分类性能。重要性热图显示,该算法侧重于咽后壁区域,而血管主要位于该区域:结果表明,基于深度学习的算法可以利用咽部图像高精度地检测出高血压。
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来源期刊
CiteScore
6.10
自引率
4.90%
发文量
40
审稿时长
18 weeks
期刊最新文献
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