Plasma Profiling of Acute Myeloid Leukemia With Fever- and Infection-Related Complications During Chemotherapy-Induced Neutropenia

IF 1.9 Q4 ONCOLOGY Cancer reports Pub Date : 2024-10-23 DOI:10.1002/cnr2.70024

Iris C. Kreft, Annemarie van de Geer, Eva R. Smit, Carmen van der Zwaan, Floris P. J. van Alphen, Alexander B. Meijer, Erfan Nur, Arie J. Hoogendijk, Taco W. Kuijpers, Maartje van den Biggelaar

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Abstract

Background

Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.

Aims

We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.

Material and Methods

Longitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.

Results

Mass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications.

Discussion and Conclusion

These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.

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急性髓性白血病化疗期间发热和感染并发症的血浆谱分析

背景：急性髓性白血病（AML）是一种需要积极治疗的异质性复杂血癌。目的：我们研究了 26 名急性髓性白血病患者在化疗引起的中性粒细胞减少症期间血浆蛋白水平与发热和感染相关并发症之间的关系：采用数据依赖性质谱分析法进行纵向血浆分析：基于质谱的血浆分析数据与实验室参数（包括C反应蛋白）相关性良好，并揭示了与发热和感染相关并发症有关的更广泛的炎症蛋白网络：这些数据表明，对急性髓细胞性白血病患者进行纵向血浆分析具有识别和预测并发症的潜力，有助于改善疾病监测和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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