Learning from those who thrive: protective factors and neuroimaging markers in adolescents with complex congenital heart disease and with a favorable neurodevelopmental profile.

IF 1.6 3区 心理学 Q3 CLINICAL NEUROLOGY Child Neuropsychology Pub Date : 2024-10-25 DOI:10.1080/09297049.2024.2419048
Melanie Ehrler, Ruth O'Gorman, Flavia Maria Wehrle, Anna Speckert, Andras Jakab, Oliver Kretschmar, Beatrice Latal
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Abstract

Patients with complex congenital heart disease (cCHD) are at risk for neurodevelopmental impairments, yet many patients develop normally. This study investigated associations between a favorable neurodevelopmental profile and protective factors, quality of life (QoL), resilience, and brain development. Adolescents with cCHD (n = 100) were prospectively enrolled. Neurodevelopmental profiles comprised IQ, executive functions, and behavior. Standardized neuropsychological tests and questionnaires were used to assess neurodevelopmental outcomes, family factors, QoL, and resilience. Clinical data were obtained from medical charts. Cerebral MRI was acquired. Specific neurodevelopmental profiles were identified by latent profile analysis and were associated with clinical and family factors, QoL and resilience, and MRI markers. We identified two distinct groups of neurodevelopmental profiles (favorable profile: n = 57, vulnerable profile: n = 43). The favorable profile group had significantly better neurodevelopmental outcome, better family functioning, and better parental mental health compared to the vulnerable profile group. Clinical factors were not significantly associated with profile group. The favorable profile group reported significantly better QoL and resilience and had larger total brain volumes. A positive family environment may be protective for long-term neurodevelopment and may outweigh the role of clinical factors. This study underlines the importance of family-centered care to promote favorable brain development and neurodevelopmental outcome.

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向茁壮成长者学习:患有复杂先天性心脏病且神经发育状况良好的青少年的保护因素和神经影像标记。
复杂先天性心脏病(cCHD)患者有神经发育障碍的风险,但许多患者发育正常。本研究调查了良好的神经发育状况与保护因素、生活质量(QoL)、恢复能力和大脑发育之间的关系。研究人员前瞻性地招募了患有慢性阻塞性肺疾病的青少年(n = 100)。神经发育概况包括智商、执行功能和行为。标准化的神经心理学测试和调查问卷用于评估神经发育结果、家庭因素、生活质量和适应能力。临床数据来自病历。采集了大脑核磁共振成像。通过潜在特征分析确定了特定的神经发育特征,并将其与临床和家庭因素、QoL和恢复能力以及磁共振成像标记物联系起来。我们确定了两组不同的神经发育特征(有利特征:n = 57,脆弱特征:n = 43)。与易感基因组相比,有利基因组的神经发育结果、家庭功能和父母的心理健康都明显更好。临床因素与特征组无明显关联。有利特征组的生活质量和适应能力明显更好,脑容量也更大。积极的家庭环境可能对长期的神经发育具有保护作用,并可能超过临床因素的作用。本研究强调了以家庭为中心的护理对促进良好的大脑发育和神经发育结果的重要性。
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来源期刊
Child Neuropsychology
Child Neuropsychology 医学-临床神经学
CiteScore
4.10
自引率
9.10%
发文量
71
审稿时长
>12 weeks
期刊介绍: The purposes of Child Neuropsychology are to: publish research on the neuropsychological effects of disorders which affect brain functioning in children and adolescents, publish research on the neuropsychological dimensions of development in childhood and adolescence and promote the integration of theory, method and research findings in child/developmental neuropsychology. The primary emphasis of Child Neuropsychology is to publish original empirical research. Theoretical and methodological papers and theoretically relevant case studies are welcome. Critical reviews of topics pertinent to child/developmental neuropsychology are encouraged. Emphases of interest include the following: information processing mechanisms; the impact of injury or disease on neuropsychological functioning; behavioral cognitive and pharmacological approaches to treatment/intervention; psychosocial correlates of neuropsychological dysfunction; definitive normative, reliability, and validity studies of psychometric and other procedures used in the neuropsychological assessment of children and adolescents. Articles on both normal and dysfunctional development that are relevant to the aforementioned dimensions are welcome. Multiple approaches (e.g., basic, applied, clinical) and multiple methodologies (e.g., cross-sectional, longitudinal, experimental, multivariate, correlational) are appropriate. Books, media, and software reviews will be published.
期刊最新文献
Neurocognitive outcomes following intracerebral hemorrhage in childhood. The relationship between executive functions and mathematics achievements in early-grade elementary students. Learning from those who thrive: protective factors and neuroimaging markers in adolescents with complex congenital heart disease and with a favorable neurodevelopmental profile. Training rapid automatized naming in children with developmental Dyslexia. Sensory processing, executive function, and behavior in children with ADHD.
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