Trigeminal neuralgia and risk of cancer: A population-based cohort study.

IF 5 2区医学 Q1 CLINICAL NEUROLOGY Cephalalgia Pub Date : 2024-10-01 DOI:10.1177/03331024241292637

Malene Risager Lykke, Holly C Elser, Cecilia Hvitfeldt Fuglsang, Dóra Körmendiné Farkas, Henrik Toft Sørensen

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Abstract

Background: Evidence of an association between trigeminal neuralgia (TN) and subsequent cancer risk remains sparse. The present study aimed to examine the association between TN and cancer risk in the Danish population.

Methods: A nationwide population-based cohort study using hospital diagnoses collected routinely and prospectively from Danish population-based registries in 1994-2022.

Results: We identified 7846 individuals with a first-time diagnosis of TN. Within one year of diagnosis, we observed 193 cancer cases (standardized incidence rate (SIR) = 2.45, 95% confidence interval (CI) = 2.11-2.82). Absolute risk (AR) for all cancers within one year of TN diagnosis was 2.5% (95% CI = 2.2-2.9). Cancers of the head, neck and nervous system were most strongly associated with TN (AR 0.9% (95% CI = 0.7-1.1); SIR = 13.5 (95% CI = 10.5-17.0)) and the risk was persistently elevated one year after TN diagnosis. We observed 827 cancer diagnoses beyond one year after TN diagnosis, where smoking related cancers were associated with elevated cancer risk (SIR 1.13 = (95% CI = 0.98-1.29)).

Conclusions: TN was associated with an elevated risk of cancers of the head, neck and nervous system including site-specific cancers in the area. Our results suggest the potential importance of smoking related tumors in TN, either as a symptom, cause or shared risk factor.

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三叉神经痛与癌症风险：一项基于人群的队列研究。

背景：有关三叉神经痛（TN）与后续癌症风险之间关系的证据仍然很少。本研究旨在调查丹麦人群中三叉神经痛与癌症风险之间的关系：方法：1994-2022 年期间，利用丹麦人口登记处定期和前瞻性收集的医院诊断结果，在全国范围内开展基于人口的队列研究：我们确定了 7846 名首次诊断为 TN 的患者。在确诊后一年内，我们观察到 193 例癌症病例（标准化发病率 (SIR) = 2.45，95% 置信区间 (CI) = 2.11-2.82）。TN确诊后一年内所有癌症的绝对风险（AR）为2.5%（95% CI = 2.2-2.9）。头颈部和神经系统癌症与 TN 的关联度最高（AR = 0.9% (95% CI = 0.7-1.1)；SIR = 13.5 (95% CI = 10.5-17.0)），且在 TN 诊断一年后风险持续升高。我们还观察到 827 例在 TN 诊断一年后确诊的癌症，其中与吸烟相关的癌症与癌症风险升高有关（SIR 1.13 = (95% CI = 0.98-1.29)）：TN与头颈部和神经系统癌症风险升高有关，包括该部位的特异性癌症。我们的研究结果表明，与吸烟有关的肿瘤在TN中具有潜在的重要性，它可能是一种症状、病因或共同的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cephalalgia 医学-临床神经学

CiteScore

10.10

自引率

6.10%

发文量

108

审稿时长

4-8 weeks

期刊介绍： Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.